Odessy Shampoo 60ml

✔️ Uses of Odessy Shampoo

• Treatment and prevention of dandruff.

✔️ How does Odessy Shampoo work?

Odessy Shampoo binds to the fungal p450 enzymes and stops the cells from making ergosterol of the cell wall which is necessary for them to grow.

✔️ Side Effects of Odessy Shampoo

• Allergic reactions including swelling of face, lips, tongue, or throat
• Severe irritation or reddening of the skin
• Peeling or blistering of the skin
• Dryness
• Hair discoloration
• Abnormal hair texture
• Eye irritation
• Acne
• Skin inflammation (dermatitis)
• Flaking skin

✔️ Quick Suggestions:

• Allergic reactions including swelling of face, lips, tongue, or throat
• Severe irritation or reddening of the skin
• Peeling or blistering of the skin
• Dryness
• Hair discoloration
• Abnormal hair texture
• Eye irritation
• Acne
• Skin inflammation (dermatitis)
• Flaking skin

✔️ Indication OF Odessy Shampoo

• Odessy Shampoo is used for the treatment and prevention of fungal infections of the skin and scalp such as dandruff.
• Leave the shampoo on for three to five minutes before rinsing.
• Take care to avoid getting it in your eyes. If accidental exposure occurs, rinse immediately with plenty of water.
• Your usual shampoo can be used as necessary between treatments with Odessy Shampoo.

✔️ Pharmacology

Odessy Shampoo is an antifungal medicine used to treat fungal infections of the skin. It works by killing the fungus that causes the infections. It kills fungi by destroying the fungal cell membrane.

✔️ Dosage and Administration of Odessy Shampoo

Ketoconazole 2 percent shampoo is a broad-spectrum imidazole-dioxolane synthetic antifungal drug that alters the permeability of the cell membrane to prevent the in vitro growth of the following common dermatophytes and yeasts: Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum; yeasts: Candida albicans, Malassezia ovale (Pityrosporum ovale), and Candida tropicalis; and Malassezia furfur, the organism that causes tinea versicolor (Pityrosporum orbiculare).

✔️ The Direction of use:

The affected areas of the skin or the scalp should be washed with ketoconazole 2% shampoo, which should be left on the skin/scalp for 3 to 5 minutes before rinsing.
Treatment:

• Pityriasis Versicolor: Once daily for 5 days.
• Seborrhoeic dermatitis and pityriasis capitis: Twice weekly for 2 to 4 weeks.

Prophylaxis:

• Pityriasis Versicolor: Once daily for 3 days during a single treatment course before the summer.
• Seborrhoeic dermatitis and pityriasis capitis: Once every 1 or 2 weeks

✔️ The Direction of use:

• Wet your hair and scalp well with water. Apply enough shampoo and gently massage it over your entire scalp. Keep it for 5-10 mins before rinsing off. Rinse your hair and scalp with water.
• Odessy Shampoo may be irritating to the mucous membranes of the eyes and contact with this area should be avoided.
• If Odessy Shampoo does get into the eyes, they should be bathed gently with cold water.

✔️ Interaction

• Reduced absorption: Antimuscarinics, antacids, H2-blockers, proton pump inhibitors (PPIs), and sucralfate may decrease the absorption of ketoconazole.
• Reduced plasma concentrations: Drugs such as rifampicin, isoniazid, efavirenz, nevirapine, and phenytoin can reduce the plasma concentrations of ketoconazole. Ketoconazole may also decrease the concentrations of isoniazid and rifampicin.
• Reduced efficacy of oral contraceptives: Ketoconazole may reduce the effectiveness of oral contraceptives, so alternative or additional contraceptive methods should be considered.
• Increased serum levels of CYP3A4 substrates: Ketoconazole can increase the serum levels of drugs metabolized by the CYP3A4 enzyme, such as digoxin, oral anticoagulants, sildenafil, and tacrolimus. Close monitoring and dosage adjustments may be necessary.
• Potentially fatal interactions: Ketoconazole can potentiate and prolong the sedative and hypnotic effects of midazolam and triazolam, leading to serious adverse effects.
• Prolonged QT intervals: Ketoconazole can increase plasma levels and prolong QT intervals of certain drugs like astemizole, cisapride, dofetilide, pimozide, quinidine, and terfenadine, which may increase the risk of a specific type of dangerous heart rhythm called torsade de pointes.
• Increased risk of myopathy: There is an increased risk of myopathy when ketoconazole is used together with HMG-CoA reductase inhibitors (e.g., lovastatin, simvastatin).
• Markedly increased plasma levels: Nisoldipine levels can be significantly increased when used concomitantly with ketoconazole.
• Increased risk of hyperkalemia and hypotension: Concurrent use of eplerenone and ketoconazole may increase the risk of hyperkalemia (high potassium levels) and hypotension (low blood pressure).
• Increased risk of vasospasm: The use of ergot alkaloids (e.g., ergotamine, dihydroergotamine) in combination with ketoconazole may increase the risk of vasospasm, potentially leading to cerebral ischemia.

✔️ Contraindications

In patients who have a known hypersensitivity to ketoconazole, it is not recommended.

✔️ Pregnancy & Lactation

Pregnancy and lactation are not contraindications for using ketoconazole shampoo 2% since ketoconazole is not absorbed through the skin after topical application.

✔️ Precautions & Warnings

For patients who have been using topical corticosteroids for an extended period of time, it is advised to gradually discontinue the steroid therapy over a period of 2 to 3 weeks while simultaneously using Ketoconazole 2% shampoo. This gradual withdrawal helps prevent any potential rebound effects.

When using the shampoo, it is important to avoid contact with the eyes. In case the shampoo does come into contact with the eyes, it should be rinsed out immediately with plenty of water.

Regarding lactation, it is not known whether Ketoconazole is distributed in breast milk. Therefore, caution should be exercised when using shampoo during lactation. It is recommended to consult with a healthcare professional for further guidance and advice in this situation.

✔️ Storage Conditions

• Store the  Odessy Shampoo in a closed container at room temperature, away from heat, moisture, and direct light.
• Keep out of reach of children. Do not use it after the expiry date.