Lotepred Plus is a combination ophthalmic suspension containing Loteprednol Etabonate 5 mg/mL (0.5%) and Tobramycin 3 mg/mL (0.3%). It is used for steroid-responsive inflammatory conditions of the eye when corticosteroid treatment is appropriate, and there is an existing superficial bacterial infection or a risk of bacterial infection.
It may be prescribed for inflammation affecting the conjunctiva, cornea, and anterior segment of the eye, including allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, and cyclitis. It may also be used for chronic anterior uveitis, ocular injuries caused by chemical, radiation, or thermal burns, foreign-body-related corneal injury, and inflammation following eye surgery.
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Each mL contains:
Inactive ingredients:
Preservative:
- If symptoms do not improve within 2 days, the eye should be reassessed by a healthcare professional.
- When Lotepred Plus is used for 10 days or longer, intraocular pressure should be monitored.
- Prolonged corticosteroid use can increase the risk of glaucoma and other ocular complications.
- Persistent corneal ulceration during or after steroid treatment may indicate fungal infection; fungal involvement should therefore be considered.
- If redness or itching worsens during treatment, discontinue self-treatment and seek medical advice.
- Avoid touching the dropper tip to the eye, eyelids, fingers, or any other surface to prevent contamination.
- Contact lens wearers should follow their doctor's instructions. If the eye is not red, wait at least 10 minutes after applying the drops before reinserting soft contact lenses.
- Use only for the duration prescribed by your ophthalmologist.
Shake the bottle thoroughly before each use.
Instill 1 drop into the conjunctival sac of the affected eye(s) every 4–6 hours.
During the initial 24–48 hours, your doctor may increase the frequency to 1 drop every 1–2 hours, depending on the severity of the condition.
Use the medicine exactly as prescribed by your ophthalmologist. Do not increase or decrease the frequency without medical advice.
Pregnancy:
There are no adequate and well-controlled studies of Lotepred Plus in pregnant women. It should be used during pregnancy only when the expected therapeutic benefit is considered to outweigh the potential risk to the fetus.
Breastfeeding:
It is not established whether topical ophthalmic corticosteroids produce sufficient systemic absorption to result in clinically significant amounts in breast milk. Caution is therefore advised when Lotepred Plus is used by breastfeeding women.
Because loteprednol etabonate is not detected in plasma following topical ophthalmic administration, it is not expected to significantly affect the pharmacokinetics of medicines administered systemically.
Nevertheless, inform your doctor about all medicines and eye preparations you are using before starting treatment.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.