Esogut is indicated for managing dyspeptic symptoms often linked to delayed gastric emptying, gastroesophageal reflux, and esophagitis. It effectively relieves:
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Domperidone works by selectively blocking dopamine (D₂) receptors in the chemoreceptor trigger zone and the stomach. This action enhances gastrointestinal motility, accelerates gastric emptying, increases esophageal peristalsis, and strengthens lower esophageal sphincter tone—helping prevent reflux. As domperidone poorly crosses the blood-brain barrier, it has minimal neurological side effects.
Take 15–30 minutes before meals and, if needed, before bedtime.
Adults: 10–20 mg every 6–8 hours (max 80 mg/day)
Children: 0.2–0.4 mg/kg every 6–8 hours
CYP3A4 inhibitors (e.g., azole antifungals, macrolides, protease inhibitors, and nefazodone) may increase domperidone levels. Avoid combining with antacids or antisecretory drugs, as they reduce absorption. Domperidone can alleviate peripheral side effects of dopaminergic drugs (e.g., bromocriptine, L-DOPA) without affecting their central activity.
Generally well tolerated. Rarely, mild intestinal cramps, rash, urticaria, or transient neurological symptoms (especially in children) may occur. Elevated prolactin levels can cause galactorrhea or gynecomastia in rare cases.
Use during pregnancy only if the benefits outweigh the potential risks. Small amounts may pass into breast milk—breastfeeding is not recommended during treatment unless necessary.
Use with caution in children and patients with hepatic impairment. In infants, immature blood-brain barrier may increase risk of neurological effects.
Store below 30°C, protected from light and moisture.
Keep out of reach of children.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.