Fosfomycin trometamol is a synthetic, broad-spectrum, bactericidal antibiotic. It inhibits bacterial cell wall synthesis by irreversibly blocking the enzyme enolpyruvyl transferase, an early and essential step in cell wall formation.
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Fosfomycin is indicated only for the treatment of uncomplicated urinary tract infections (acute cystitis) in women, caused by susceptible strains of Escherichia coli and Enterococcus faecalis.
Adult women (≥18 years): One sachet as a single oral dose
Preparation:
Dissolve the full contents of one sachet in 100 ml of water, stir well, and drink immediately.
Diarrhea, headache, nausea, vaginitis, dizziness, abdominal pain, dyspepsia, rash.
Pregnancy Category B. Use only if the potential benefit outweighs the risk. Breastfeeding should be discontinued or avoided during therapy.
Use only a single dose for one episode of acute cystitis
Repeated dosing increases adverse effects without improving efficacy
Risk of Clostridium difficile–associated diarrhea
Store below 25°C, protected from light and moisture. Keep out of reach of children.
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