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Anlet Plus 1 Strip
Aspirin 75 mg + Clopidogrel 75 mg Tablet
Clopidogrel:
- A prodrug that requires metabolic activation to exert its effects.
- It works by irreversibly binding to P2Y12 receptors on platelets, preventing platelet activation and aggregation.
- The antiplatelet effect starts within 2 hours of a single dose, with peak activity achieved between days 3 and 7 of regular dosing (75 mg daily).
Aspirin:
- It irreversibly inhibits platelet cyclooxygenase (COX) enzymes, blocking thromboxane A2 synthesis. This action reduces platelet aggregation and vasoconstriction.
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✅ Description:
Anlet Plus-
Acute Coronary Syndrome (ACS)
Anlet PLUS is prescribed to lower the risk of heart attack (myocardial infarction) and stroke in patients diagnosed with:
- Non-ST-segment elevation ACS: Includes unstable angina (UA) and non-ST-elevation myocardial infarction (NSTEMI).
- Acute ST-segment elevation ACS: Also known as ST-elevation myocardial infarction (STEMI).
In individuals with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease, Anlet PLUS helps reduce the likelihood of recurrent MI or stroke.
Note: Always consult a registered medical professional before taking this medication.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects of Anlet Plus
- Abdominal pain, diarrhea, bruising, nosebleeds, and gastrointestinal bleeding.
- Thrombotic thrombocytopenic purpura (TTP), which requires immediate medical attention.
✔️ Pharmacokinetics
- Absorption: Clopidogrel is rapidly absorbed, with at least 50% bioavailability. Peak plasma concentrations of the main circulating metabolite occur approximately 1 hour after a 75 mg dose.
- Metabolism: Clopidogrel undergoes rapid hepatic metabolism, primarily converting into an inactive carboxylic acid derivative, which constitutes 85% of circulating drug-related compounds.
- Excretion: The drug is excreted in both urine (50%) and feces (46%) over five days. Its active metabolite has a half-life of 8 hours.
- Protein Binding: Both Clopidogrel and its metabolite bind to plasma proteins (>90%).
- Food Effect: Food intake does not significantly alter Clopidogrel’s bioavailability.
✔️ Overdose Management
- Clopidogrel: Overdose may lead to excessive bleeding. Platelet transfusion might help restore clotting function.
- Aspirin: Symptoms range from dizziness and nausea to severe complications like respiratory or metabolic acidosis. Treatment includes gastric lavage, supportive care, and, if necessary, hemodialysis.
✔️ Quick Suggestions:
- Take Anlet PLUS regularly, at the same time each day, with food to minimize stomach upset.
- Avoid activities that increase the risk of bleeding, such as shaving with razors or using sharp objects.
- Inform your doctor before any surgery or dental procedures.
- Maintain a healthy lifestyle, including a low-fat diet and regular exercise, to maximize treatment benefits.
✔️ Dosage and Administration of Anlet Plus
- General Dosing: 75 mg once daily, with or without food.
- ACS Treatment: Start with a loading dose of 300 mg, followed by 75 mg daily. Aspirin (75-325 mg daily) should be co-administered.
- Elderly and Renal Patients: No dosage adjustment is needed.
✔️ Pregnancy:
- Use during the first two trimesters only if necessary. Avoid during the third trimester.
✔️ Lactation:
- Clopidogrel’s excretion in breast milk is unknown, but Aspirin is excreted; discontinue during breastfeeding.
✔️ Children:
- Not recommended for those under 12 years due to the risk of Reye's syndrome, particularly in viral illnesses like influenza or chickenpox.
✔️ Drug Interactions
- Aspirin: Enhances Clopidogrel's effect without altering its platelet inhibition mechanism.
- NSAIDs: Increased risk of gastrointestinal (GI) bleeding. Use with caution.
- Heparin: No dosage adjustment is required, but co-administration should be monitored.
- Warfarin: Combining Clopidogrel with Warfarin raises bleeding risk and should be done with caution.
✔️ Do not use Anlet PLUS in the following situations:
- Hypersensitivity to Aspirin, Clopidogrel, or other components.
- Active bleeding, such as from peptic ulcers or intracranial hemorrhage.
✔️ Precautions and Warnings
- Bleeding Risk: Anlet PLUS prolongs bleeding time, so exercise caution during surgery or in conditions with high bleeding risks.
- Reye’s Syndrome: Aspirin use in children can lead to Reye’s syndrome, a potentially fatal condition.
- Liver and Kidney Impairment: Avoid use in severe hepatic impairment or renal dysfunction.
✔️ Storage
- Store in a cool, dry place below 30°C, protected from light and moisture.
- Keep out of the reach of children.
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lab tests, medicines, all possible side effects, drug interactions,
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and discuss all your queries related to any disease or medicine. We
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