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Clas 75+75 Tablet
(Clopidogrel + Aspirin)
1. Acute Coronary Syndrome (ACS):
Clas® is indicated to reduce the risk of myocardial infarction (MI) and stroke in patients with:
- Non-ST-elevation ACS (NSTEMI and unstable angina)
- ST-elevation myocardial infarction (STEMI)
2. Secondary Prevention:
Used to lower the risk of MI and stroke in patients with a history of:
- Recent MI
- Recent stroke
- Established peripheral arterial disease (PAD)
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✅ Description:
Clopidogrel is a prodrug that irreversibly inhibits platelet aggregation by blocking ADP receptors (P2Y12) on platelets. Platelet inhibition begins within 2 hours of a single dose, with full effect achieved between days 3 and 7 on continuous dosing.
Aspirin irreversibly inhibits cyclooxygenase (COX), reducing thromboxane A2 formation—a potent promoter of platelet aggregation and vasoconstriction.
Absorption: Clopidogrel is rapidly absorbed, with peak levels of its active metabolite occurring ~1 hour post-dose.
Bioavailability: At least 50% absorbed based on urinary metabolite excretion.
Protein Binding: Clopidogrel – 98%, Metabolite – 94% (non-saturable).
Metabolism: Primarily in the liver to inactive carboxylic acid derivative.
Excretion: ~50% in urine, ~46% in feces within 5 days.
Half-life: ~8 hours for the main metabolite.
Food does not significantly affect bioavailability.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
Standard Dose: 75 mg once daily (with or without food).
ACS Protocol:
Initial loading dose: 300 mg of Clopidogrel
Maintenance dose: 75 mg daily
Aspirin co-administration: 75–325 mg once daily
Elderly and Renal Patients: No dose adjustment required.
Most ACS patients also receive acute-phase heparin therapy.
- Pregnancy: Should be used only when clearly necessary in the 1st and 2nd trimesters. Contraindicated in the 3rd trimester.
- Lactation: Not recommended during breastfeeding. Aspirin is known to be excreted in breast milk.
May prolong bleeding time—use with caution in patients at risk of bleeding.
Avoid in children <12 years due to the risk of Reye’s syndrome, particularly if recovering from viral infections.
Monitor for signs of hypersensitivity.
✔️ Drug Interactions
Aspirin: No alteration of ADP-inhibition; may enhance aspirin’s effect on collagen-induced aggregation.
Heparin: No dose adjustment needed; no effect on coagulation.
NSAIDs: Risk of gastrointestinal bleeding increases with concurrent use.
Warfarin: Co-administration requires caution due to bleeding risk.
✔️ Contraindications
- Known hypersensitivity to any component
- Active bleeding (e.g., peptic ulcer, intracranial hemorrhage.
✔️ Clas is generally well-tolerated. However, rare cases of:
- Rash, angioedema
- Hematological reactions
- Thrombotic thrombocytopenic purpura (TTP)
✔️ Overdose Management
Clopidogrel: May result in bleeding—platelet transfusion may help restore hemostasis.
Aspirin: Overdose can cause dizziness, tinnitus, confusion, and GI symptoms. Severe cases may lead to acidosis, hyperthermia, and dehydration—manage with gastric lavage, hydration, and dialysis.
✔️ Storage Instructions
Store below 30°C in a cool, dry place away from light and moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
