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Clas 75+75 Tablet
(Clopidogrel + Aspirin)
1. Acute Coronary Syndrome (ACS):
Clas® is indicated to reduce the risk of myocardial infarction (MI) and stroke in patients with:
- Non-ST-elevation ACS (NSTEMI and unstable angina)
- ST-elevation myocardial infarction (STEMI)
2. Secondary Prevention:
Used to lower the risk of MI and stroke in patients with a history of:
- Recent MI
- Recent stroke
- Established peripheral arterial disease (PAD)
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✅ Description:
Clopidogrel is a prodrug that irreversibly inhibits platelet aggregation by blocking ADP receptors (P2Y12) on platelets. Platelet inhibition begins within 2 hours of a single dose, with full effect achieved between days 3 and 7 on continuous dosing.
Aspirin irreversibly inhibits cyclooxygenase (COX), reducing thromboxane A2 formation—a potent promoter of platelet aggregation and vasoconstriction.
Absorption: Clopidogrel is rapidly absorbed, with peak levels of its active metabolite occurring ~1 hour post-dose.
Bioavailability: At least 50% absorbed based on urinary metabolite excretion.
Protein Binding: Clopidogrel – 98%, Metabolite – 94% (non-saturable).
Metabolism: Primarily in the liver to inactive carboxylic acid derivative.
Excretion: ~50% in urine, ~46% in feces within 5 days.
Half-life: ~8 hours for the main metabolite.
Food does not significantly affect bioavailability.
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✔️ Dosage & Administration
Standard Dose: 75 mg once daily (with or without food).
ACS Protocol:
Initial loading dose: 300 mg of Clopidogrel
Maintenance dose: 75 mg daily
Aspirin co-administration: 75–325 mg once daily
Elderly and Renal Patients: No dose adjustment required.
Most ACS patients also receive acute-phase heparin therapy.
- Pregnancy: Should be used only when clearly necessary in the 1st and 2nd trimesters. Contraindicated in the 3rd trimester.
- Lactation: Not recommended during breastfeeding. Aspirin is known to be excreted in breast milk.
May prolong bleeding time—use with caution in patients at risk of bleeding.
Avoid in children <12 years due to the risk of Reye’s syndrome, particularly if recovering from viral infections.
Monitor for signs of hypersensitivity.
✔️ Drug Interactions
Aspirin: No alteration of ADP-inhibition; may enhance aspirin’s effect on collagen-induced aggregation.
Heparin: No dose adjustment needed; no effect on coagulation.
NSAIDs: Risk of gastrointestinal bleeding increases with concurrent use.
Warfarin: Co-administration requires caution due to bleeding risk.
✔️ Contraindications
- Known hypersensitivity to any component
- Active bleeding (e.g., peptic ulcer, intracranial hemorrhage.
✔️ Clas is generally well-tolerated. However, rare cases of:
- Rash, angioedema
- Hematological reactions
- Thrombotic thrombocytopenic purpura (TTP)
✔️ Overdose Management
Clopidogrel: May result in bleeding—platelet transfusion may help restore hemostasis.
Aspirin: Overdose can cause dizziness, tinnitus, confusion, and GI symptoms. Severe cases may lead to acidosis, hyperthermia, and dehydration—manage with gastric lavage, hydration, and dialysis.
✔️ Storage Instructions
Store below 30°C in a cool, dry place away from light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
