Osteoarthritis is a joint disorder that occurs when the protective cartilage covering the bone ends wears away. Without this cushioning, the bones rub directly against each other, leading to pain, stiffness, and reduced mobility. Common symptoms include pain, stiffness, swelling, inflammation, and tenderness.
Rheumatoid arthritis is an autoimmune condition in which the body’s immune system mistakenly attacks its own tissues, primarily affecting the joints. This results in pain, swelling, stiffness, joint deformities, and loss of joint function
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Adults
Osteoarthritis: Start with 1 g orally once daily. Maintenance dose: 1–2 g per day, either as a single daily dose or split every 12 hours. Do not exceed 2 g daily.
Rheumatoid arthritis: Start with 1 g orally once daily. Maintenance dose: 1–2 g per day, as a single daily dose or in divided doses every 12 hours. Maximum dose 2 g daily.
Elderly patients: Some may respond to 500 mg daily, with a maximum of 1 g daily.
Children
Not recommended.
Renal Impairment
CrCl 30–49 ml/min: Initial dose 750 mg once daily, may be increased up to 1.5 g daily if needed.
CrCl <30 ml/min: Initial dose 500 mg once daily, maximum 1 g daily.
Drug–Drug: Inform your doctor if you are taking antidepressants (duloxetine, escitalopram, fluoxetine, sertraline), diuretics (hydrochlorothiazide), antihypertensives (lisinopril), corticosteroids (prednisone), or antidiabetics (metformin).
Drug–Food: No significant food interactions reported.
Drug–Disease: Use with caution if you have asthma, fluid retention, gastrointestinal disease, kidney or liver problems, thrombosis, anemia, heart disease, hypertension, hyperkalemia, or bleeding disorders.
May be taken with or without food, as prescribed.
Usually taken once or twice daily.
Swallow the tablet whole with water—do not crush, break, or chew.
Do not take Nabumetone if you are allergic to its ingredients, aspirin, or other NSAIDs, or if you have a history of stomach/peptic ulcers, gastrointestinal bleeding, perforation, severe heart failure, cirrhosis, kidney disease, or if you are in the last trimester of pregnancy or breastfeeding.
Consult your doctor if you have a history of asthma, Crohn’s disease, ulcerative colitis, liver/kidney/heart conditions, hypertension, stroke, edema, autoimmune disorders, diabetes, high cholesterol, infections, smoking habit, or are above 65 years of age. Nabumetone is not suitable for children.
Seek urgent medical attention if you experience breathing difficulty, swelling of the face or throat, severe blistering rash, chest pain, sudden weakness/numbness, confusion, black or tarry stools, or blood in vomit. Avoid use if you have recently had a heart attack unless specifically advised by your doctor.
Nabumetone may cause serious gastrointestinal issues such as bleeding, ulcers, or perforation of the stomach/intestines. Stop treatment and consult your doctor immediately if you develop stomach pain, vomiting blood or coffee-ground-like material, heartburn, or bloody/black stools.
Keep in a cool, dry place away from sunlight. Store out of reach of children.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.