Tigover 10mg Tablet 1 Strip

✔️ Migraine Prevention

• Patients under 65 years: 10 mg once daily at bedtime.
• Patients over 65 years: 5 mg once daily.

If depression, extrapyramidal symptoms, or other significant adverse effects develop, treatment should be discontinued. Patients who show no meaningful improvement after two months should be considered non-responders, and therapy should be stopped.

For maintenance therapy, patients who respond well may continue treatment at the same dose for five consecutive days each week, followed by two drug-free days. Even when effective, treatment should generally be interrupted after six months and restarted only if migraine symptoms recur.

✔️ Peripheral Vascular Disease

• 10 mg twice daily, with doses up to 30 mg daily if necessary.

✔️ Adjunctive Treatment in Epilepsy

• Adults: 15–20 mg daily.
• Children: 5–10 mg daily.

✔️ Vertigo and Motion Sickness

• Adults: 10–20 mg daily.
• Children weighing more than 40 kg: 5 mg daily.

✔️ Side Effects

Common adverse effects include:

• Drowsiness
• Fatigue
• Increased appetite
• Weight gain

Less common but clinically important effects include:

• Depression
• Bradykinesia
• Rigidity
• Akathisia
• Orofacial dyskinesia
• Tremor

Other infrequently reported reactions include:

• Heartburn
• Nausea
• Gastric discomfort
• Insomnia
• Anxiety
• Galactorrhea
• Dry mouth
• Muscle pain
• Skin rash

✔️ Tigover should not be used in patients with:

• Hypersensitivity to flunarizine.
• Current or previous depressive disorders.
• Parkinson's disease.
• Existing extrapyramidal movement disorders.

✔️ Interaction

Women taking oral contraceptives may occasionally experience galactorrhea during the first few months of treatment. Enzyme-inducing antiepileptic drugs such as carbamazepine and phenytoin can increase the metabolism of flunarizine, potentially reducing its effectiveness and necessitating dosage adjustments.

✔️ Pregnancy and Lactation

The safety of flunarizine during pregnancy and breastfeeding has not been firmly established. It should be used only when the potential benefits outweigh the potential risks and under medical supervision.