Milk thistle (Silybum marianum) is a flowering herb that has been used for over 2,000 years as a natural remedy for hepatic (liver) and biliary (gallbladder) disorders. Recognizable by its prickly leaves with white veins and purple flowers, it is most famous for its active compound: Silymarin.
Research into milk thistle primarily focuses on its antioxidant and anti-inflammatory properties.
The primary mechanism involves Silymarin, which is actually a group of compounds (the most potent being Silybin). It works by:
Milk thistle is generally considered safe for most people, but there are a few things to keep in mind:
| Category | Consideration |
|---|---|
| Forms | Available as capsules, tablets, liquid extracts, and tea. |
| Side Effects | Rare, but can include mild digestive upset (diarrhea or bloating). |
| Allergies | People allergic to ragweed, daisies, or marigolds may have a reaction. |
| Interactions | It can interact with certain medications metabolized by the liver. |
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JP LIVA is formulated with Milk thistle extract. Milk thistle is a plant named for the white veins on its large prickly leaves. One of the active ingredients in milk thistle called silymarin is extracted from the plant’s seeds. Silymarin is believed to have anti-oxidant and Hepatic-biliary protective properties. Milk thistle is sold as an oral capsule.
JP-LIVA is indicated for the treatment and prevention of-
Liver disease, (non-alcoholic & alcoholic)
Liver cirrhosis, (non-alcoholic & alcoholic)
Infectious hepatitis
Drug-induced hepatitis
Liver disease secondary to diabetes mellitus
Toxicity of narcotics
Fatty liver
Jaundice
Silymarin is well known hepatoprotective agent. It is prepared with standardized extract of Milk Thistle fruits. Silymarin stimulates RNA polymerase-A, enhances protein synthesis and helps to regenerate and repair liver cell.
The liver-protecting and liver-repairing functions of Silymarin are due to two main actions: antioxidant and protein-restoring activities. The antioxidant activity of silymarin is ten times more powerful than vitamin E. It prevents toxic and foreign substances from penetrating into the liver cells by stabilizing the outer membrane of liver cells.
Silymarin has also membrane stabilizing effect. It alters the liver membrane cell structure In such a way that certain toxins cannot enter into the cell. Silymarin protects liver cells (hepatocytes) from damage caused by alcohol, organic compounds, viral infections, acetaminophen, environmental pollutants and by products of metabolism including foods, drugs, chemotherapeutic ogents and other chemicals.
It also acts by anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, Immunomodulatory and liver regenerating mechanisms.
Side effect, Contraindication, Orug Interaction:There is no any significant side effect, contraindication or drug interaction observed with prescribed dosage
Pregnancy & Lactation:
No experience is available about the use of Milk thistle during pregnancy and lactation Tharefore, if needed Milk thistle should be taken with caution according to the physician’s advice.
Storage Conditions:
Store in a cool & dry place, away from light & micisture, Keep out of reach of children,
10 blister strips × 3 capsules (30 capsules)
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.