Ursocol 300mg Tablet

Uses of Ursocol 300mg Tablet

• Treatment of Primary Biliary Cirrhosis (bile acid-associated liver damage)
• Treatment of Gallbladder stones

How Ursocol 300mg Tablet works?

By improving bile flow through the liver and preserving liver cells, Ursocol 300mg Tablet helps to reduce elevated liver enzyme levels. Ursocol 300mg Tablet is a bile concentrate that reduces biliary cholesterol by blocking the synthesis of new cholesterol through intestinal absorption. Lowering cholesterol levels progressively solubilizes cholesterol from gallstones, resulting in their disintegration.

Side Effects of Ursocol 300mg Tablet

• Diarrhea
• Indigestion
• Bladder pain
• Nausea or Vomiting
• Unusual bleeding
• Weakness

Quick Suggestions:

• Ursocol 300 should be taken after a meal with a glass of milk or water.
• Foods rich in vitamins B, C, and calcium, are good for the gallbladder.
• Eat a healthy diet, exercise regularly
• Avoid tobacco and alcohol consumption.
• Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
• Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy, and every 6 months thereafter.
• Do not stop taking the medication without talking to your doctor.

Indication of Ursocol 300mg Tablet

Ursodeoxycholic Acid helps to treat

• Primary biliary cirrhosis (PBC)
• Gallstones (not visible on X-ray in patients with a functioning gall bladder)
• Liver disease associated with cystic fibrosis in children aged 6 to 18 years

Pharmacology

A naturally occurring bile acid called ursodeoxycholic acid is used to treat a number of hepatobiliary conditions. The action of ursodeoxycholic acid is based on a decrease in bile cholesterol synthesis. By lowering dietary cholesterol absorption, reducing hepatic cholesterol production, and not impairing bile acid synthesis, ursodeoxycholic acid achieves this.

Bile's composition shifts from supersaturated to unsaturated as a result. Because it encourages the growth of liquid cholesterol crystal complexes, ursodeoxycholic acid also facilitates the movement of cholesterol from the gallbladder into the intestine for excretion.

• Cholangiocytes are shielded from the cytotoxicity of hydrophobic bile acid by ursodeoxycholic acid, which aids in the treatment of cholestatic liver disease.
• Hepatobiliary secretion stimulation
• Bile acid does not cause apoptosis in hepatocytes.

Ursodeoxycholic acid is completely absorbed in the upper gut. Between 30 and 150 minutes pass before serum concentration reaches its maximum. The percentage of absorption varies from 60% to 80%. After absorption, ursodeoxycholic acid travels to the portal vein where it is taken up by the liver, conjugated with an amino acid (glycine or taurine), and then released into the hepatic bile ducts. Ursodeoxycholic acid is present in very small amounts in the blood and is only slightly excreted in the urine. The biological half-life of ursodeoxycholic acid ranges from 3.5 to 5.8 days.

Dosage & Administration of Ursocol 300mg Tablet

Gallstone dissolution: 8–12 mg/kg/day, given either all at once at night or in divided doses.

• 2-4 divided doses of 10-15 mg/kg/day for primary biliary cirrhosis
• 600 mg daily for acute viral hepatitis.
• 300 mg/day for alcoholic fatty liver.
• 25–30 mg/kg/day for primary sclerosing cholangiocarcinoma
• Gallstones and Non-Alcoholic Steato Hepatitis Dissolution: 13–15 mg/kg/day.

Take Ursocol 300mg Tablet in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ursocol 300 Tablet is to be taken with food.

Interaction

Ursodeoxycholic Acid should not be used with medicines that raise bile cholesterol, such as oestrogenic hormones. Concurrent administration of Ursodeoxycholic acid with bile-acid binding medications such as antacids, charcoal, or cholestyramine should be avoided, since this may impair the efficacy of Ursodeoxycholic acid therapy.

Contraindications

Inflammatory intestinal illness, non-functioning gallbladder, calcified and pigmented gallstones

Pregnancy & Lactation

Category B pregnancy. In pregnancy, no indication of danger has been documented. It has been successfully used to treat cholestasis in pregnant women throughout the third trimester with no adverse effects. Breastfeeding problems have not been recorded in humans.

Precautions & Warnings

It is important to follow the precautions and warnings provided by the manufacturer and your healthcare provider before taking Ursocol 300mg Tablet. 

• Ursocol 300mg Tablet should not be taken if you are allergic to any of its components or have certain medical conditions such as inflammation of the gall bladder and bile ducts, narrowing or blockage of the bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.
• If you have variceal bleeding, ascites, liver encephalopathy, or liver disease, you should inform your doctor before taking Ursocol 300mg Tablet.
• It is essential to inform your doctor if you are taking any other medications, including antibiotics such as ciprofloxacin and dapsone, antihypertensive agents such as nitrendipine, immunosuppressants such as cyclosporine, oral contraceptives such as estrogen, or cholesterol-lowering agents such as clofibrate.
• Ursocol 300mg Tablet can interact with these medications and cause unwanted side effects.
• Ursocol 300mg Tablet should not be taken during pregnancy or while breastfeeding unless prescribed by your doctor.
• Children above six years of age can take Ursocol 300mg Tablet only if prescribed by their doctor.
• Consuming alcohol with Ursocol 300mg Tablet can increase the risk of drowsiness and liver damage.
• It is important to keep your doctor informed about your health condition and medications to avoid any unpleasant side effects.
• Your doctor may recommend frequent liver function tests to check liver function and treatment progress.
• Ursocol 300mg Tablet may cause hair thinning and loss in rare cases; if there is considerable hair loss, visit your doctor for additional advice.

Storage Conditions

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.