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Daprotab 6mg Tablet 1 Strip
Daprotab 6 is prescribed for anemia due to CKD in adult patients undergoing dialysis for at least four months.
However, it is not recommended for:
- Immediate anemia correction as a substitute for blood transfusions
- Patients with CKD-related anemia who are not on dialysis
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✅ Description:
Daprotab 6 is a hypoxia-inducible factor, prolyl hydroxylase inhibitor (HIF-PHI). The function of HIF-PH enzymes regulates intracellular levels of hypoxia-inducible factor (HIF), a key transcription factor responsible for activating genes involved in erythropoiesis (red blood cell production). The HIF pathway plays a crucial role in the body's adaptive response to low oxygen levels by increasing red blood cell production.
By reversibly inhibiting HIF-PH, Daprodustat promotes a well-coordinated erythropoietic response, which includes:
- Increased levels of endogenous erythropoietin (EPO) in the blood
- Regulation of iron transporter proteins
- Reduction of hepcidin, a protein that hinders iron availability and is elevated during inflammation in chronic kidney disease (CKD)
This process enhances iron availability, boosts hemoglobin (Hb) synthesis, and leads to an increase in red blood cell mass.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage Guidelines
For Patients Not Currently on an Erythropoiesis-Stimulating Agent (ESA):
- Hb < 9 g/dL → 4 mg once daily
- Hb 9–10 g/dL → 2 mg once daily
- Hb > 10 g/dL → 1 mg once daily
For Patients Switching from an ESA:
- If previously receiving Epoetin alfa ≤ 2,000 units/week → 4 mg daily
- If previously receiving Epoetin alfa 2,000–10,000 units/week → 6 mg daily
- If previously receiving Epoetin alfa > 10,000 units/week → 8 mg daily
- If previously receiving Epoetin alfa ≥ 20,000 units/week → 12 mg daily
Maximum Dose: 24 mg once daily
- Pediatrics: Not recommended for children.
- Renal Impairment:
- No significant impact on drug exposure in patients with different levels of renal impairment.
- Hemodialysis & Peritoneal Dialysis: Drug exposure remains stable.
- Non-dialysis days: Higher exposure to drug metabolites than on dialysis days.
✔️ Possible Side Effects
- Increased risk of hospitalization due to heart failure
- High blood pressure (hypertension)
- Damage to the gastrointestinal lining, including the stomach, esophagus, and intestines
✔️ Administration & Dosage
- Oral (to be swallowed whole without crushing, chewing, or breaking)
- Can be taken with or without food
✔️ Daprotab 6 should not be used in patients who:
- Are receiving strong CYP2C8 inhibitors (e.g., gemfibrozil), as these can significantly increase drug exposure.
- Have uncontrolled hypertension.
✔️ Missed Dose Instructions
If a dose is missed, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
✔️ Drug Interactions
- CYP2C8 Inhibitors (e.g., gemfibrozil) → Contraindicated due to a marked increase in drug exposure.
- CYP2C8 Inducers (e.g., rifampin) → May decrease drug levels, leading to reduced efficacy.
✔️ Pregnancy & Lactation
- Not recommended during pregnancy due to evidence of fetal adverse effects in animal studies.
✔️ Storage:
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
