✔ 100% Authentic Product
👁️ Currently Viewing 236
Daprotab 4mg Tablet 1 Strip
Daprotab is used for the treatment of anemia due to chronic kidney disease (CKD) in adults who have been receiving dialysis for at least four months.
Daprotab is not recommended for:
- Patients requiring immediate correction of anemia as a substitute for red blood cell transfusions.
- Treatment of CKD-related anemia in patients not on dialysis.
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City- Regular Delivery - 24-48 Hours, All Over Bangladesh
ফ্রি ডেলিভারি! - ৯৯৯ টাকা+ অর্ডারে ঢাকা
শহরে ।- ফ্রি ডেলিভারি! - ২৪৯৯ টাকা+ অর্ডারে ঢাকার
বাহিরে ।
✅ Description:
Daprodustat is a hypoxia-inducible factor, prolyl hydroxylase inhibitor (HIF-PHI). It regulates HIF levels, a key transcription factor for genes involved in erythropoiesis. By reversibly inhibiting HIF-PH, Daprodustat:
✅ Increases plasma erythropoietin (EPO) levels.
✅ Regulates iron transport proteins.
✅ Reduces hepcidin (an iron-regulating protein elevated in CKD).
✅ Improves iron bioavailability and promotes red blood cell production.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
⚠ Serious Risks:
- Heart failure hospitalization.
- High blood pressure.
- Gastrointestinal erosion (damage to stomach, esophagus, and intestines).
Pregnancy & Lactation
🚫 Not recommended during pregnancy—may cause fetal harm.
🚼 Breastfeeding should be avoided until one week after the final dose.
Warnings & Precautions
⚠ Increased Risk of:
✔ Death, myocardial infarction, stroke, venous thromboembolism, & vascular access thrombosis.
✔ Hospitalization due to heart failure.
✔ Hypertension.
✔ Gastrointestinal erosion.
✔ Malignancy risk in CKD patients not on dialysis.
Use in Special Populations
✔ Children: Safety and efficacy not established.
✔ Elderly: Dose adjustments not necessary unless contraindicated.
✔️ Overdose Effects
⚠ Symptoms:
- Headache
- Nausea/GI disturbances
⚠ No specific antidote available. Hemodialysis is not effective due to high protein binding.
✔️ Dosage & Administration
Pre-Treatment & On-Treatment Evaluations
✔ Anemia & Iron Stores
- Correct other causes of anemia (e.g., vitamin deficiencies, inflammation, bleeding) before starting Daprodustat.
- Monitor iron levels before and during treatment.
- Supplemental iron therapy is recommended if serum ferritin <100 mcg/mL or transferrin saturation <20%.
✔ Liver Function Tests
- Assess ALT, AST, alkaline phosphatase, and bilirubin before initiating treatment.
- Repeat liver tests if signs of liver dysfunction appear.
✔️ Important Dosing Information
✅ Individualized dosing—Use the lowest effective dose to minimize red blood cell transfusion dependency.
✅ Do not exceed hemoglobin levels of 11 g/dL.
✅ Can be taken with or without food.
✅ Swallow whole—do not cut, crush, or chew.
✅ Dosing is independent of dialysis timing.
🚨 Missed Dose: Take as soon as possible, unless it is the same day as the next dose. Do not double the dose.
✔️ Recommended Starting Dose
For Adults with CKD on Dialysis (≥4 Months)
✔ Not on ESA Therapy:
- Dosing based on hemoglobin level before treatment.
✔ On ESA Therapy:
- Adjust based on previous ESA dose.
✔️ Monitoring & Dose Adjustments
✔ Monitor hemoglobin every 2 weeks for the first month, then every 4 weeks.
✔ Adjust doses only every 4 weeks, increasing or decreasing one level at a time.
✔ Reduce the dose if:
- Hemoglobin increases >1 g/dL in 2 weeks or >2 g/dL in 4 weeks.
- Hemoglobin exceeds 11 g/dL.
✔ Interrupt treatment if hemoglobin exceeds 12 g/dL. Resume at a lower dose when levels normalize.
✔ Discontinue use if no meaningful hemoglobin increase within 24 weeks.
✔️ Dose Adjustments for Special Populations
✔ Moderate Hepatic Impairment (Child-Pugh B): Reduce dose by half, except for those already on 1 mg.
✔ Severe Hepatic Impairment (Child-Pugh C): Not recommended.
✔ Patients on Moderate CYP2C8 Inhibitors (e.g., Clopidogrel): Reduce dose by half, except if already on 1 mg.
✔️ Drug Interactions
❌ Strong CYP2C8 Inhibitors (e.g., gemfibrozil) → Contraindicated due to increased drug exposure.
⚠ CYP2C8 Inducers (e.g., rifampin) → May reduce efficacy.
✔️ Do not use if the patient has:
- Uncontrolled hypertension.
- Concomitant use of strong CYP2C8 inhibitors (e.g., gemfibrozil)
✔️ Storage:
✔ Store below 30°C, in a cool, dry place.
✔ Keep away from light.
✔ Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
