Ajuben is prescribed for:
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Ajuben (deutetrabenazine) acts as a reversible inhibitor of vesicular monoamine transporter 2 (VMAT2).
It reduces the uptake and storage of neurotransmitters like dopamine, serotonin, norepinephrine, and histamine in nerve terminals.
This depletion of monoamines helps control abnormal involuntary movements (chorea and dyskinesia).
ওয়েবসাইট থেকে অর্ডার করার সহজ ভিডিও গাইড।
অ্যাপ থেকে অর্ডারের সহজ ভিডিও গাইড
অ্যাপ ডাউনলোডDownload ePharma App বিস্তারিত গাইড ›Detailed App Ordering GuidePediatrics: Not established in patients under 18
Hepatic/Renal Impairment: No specific studies available; use caution
Poor CYP2D6 Metabolizers: Limit dose to 36 mg/day (18 mg twice daily)
| Condition | Initial Dose | Maintenance Range | Max Dose |
|---|---|---|---|
| Chorea (Huntington’s) | 6 mg/day | 6–48 mg/day | 48 mg/day |
| Tardive Dyskinesia | 12 mg/day | 12–48 mg/day | 48 mg/day |
Titrate by 6 mg/day weekly
Divide doses ≥12 mg (e.g., 24 mg = 12 mg twice daily)
Take with food
| Tetrabenazine Dose | Initial Ajuben Dose |
|---|---|
| 12.5 mg | 6 mg once daily |
| 25 mg | 6 mg once daily |
| 37.5 mg | 9 mg once daily |
| 50 mg | 12 mg once daily |
| 62.5 mg | 15 mg once daily |
| 75 mg | 18 mg once daily |
| 87.5 mg | 21 mg once daily |
| 100 mg | 24 mg once daily |
Adjust Ajuben weekly as needed for clinical response.
Avoid strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): Maximum dose = 36 mg/day
Avoid alcohol and sedatives: May cause additive drowsiness
Pregnancy: Not enough human data – use only if clearly needed
Breastfeeding: Unknown if secreted in milk – caution advised
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