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Telmisartan
- Hypertension: Used for the treatment of essential hypertension in adults to lower blood pressure.
- Cardiovascular Prevention: Used for reducing cardiovascular morbidity in adults with:
- Atherothrombotic cardiovascular disease (including history of coronary heart disease, stroke, or peripheral arterial disease).
- Type 2 diabetes mellitus with documented target organ damage.
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✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Overdose Effects: Teana 20
- Overdose may lead to symptoms like hypotension, dizziness, tachycardia, bradycardia, increased serum creatinine, and acute renal failure, due to parasympathetic stimulation.
✔️ Pharmacology
- Telmisartan is a non-peptide angiotensin-II receptor antagonist. It works by blocking the binding of angiotensin-II to the AT1 receptor, which plays a key role in blood pressure regulation. This receptor is present in various tissues, such as the blood vessels and adrenal glands.
- By blocking angiotensin-II, Telmisartan prevents vasoconstriction, aldosterone release, cardiac stimulation, and sodium reabsorption in the kidneys.
- It has a significantly higher affinity for the AT1 receptor compared to the AT2 receptor and does not interfere with the angiotensin-converting enzyme (ACE), which affects the bradykinin pathway.
✔️ Common Side Effects: Teana 20
- For Hypertension: Sinus pain, sinus congestion (sinusitis), back pain, and diarrhea.
- For Cardiovascular Risk Reduction: Intermittent claudication and skin ulcers.
✔️ Dosage and Administration: Teana 20
- Starting Dose: The usual initial dose is 40 mg once daily.
- Dose Range: Effective blood pressure response is observed between 20-80 mg per day. The maximum reduction in blood pressure is typically seen after 4 weeks of treatment.
- If additional blood pressure reduction is needed, a combination therapy can be considered.
- Elderly or Renal Impairment: No initial dose adjustments are necessary, but blood pressure should be closely monitored in patients on dialysis due to potential orthostatic hypotension.
- Hepatic Impairment: Telmisartan should be used with caution in patients with liver issues, and dose adjustments may be required. Initial therapy is not recommended for patients aged ≥75 years or those with hepatic impairment.
✔️ Pediatric Use: Teana 20
- The safety and effectiveness of Telmisartan have not been established in pediatric patients.
✔️ Geriatric Use: Teana 20
- No significant differences in safety and effectiveness were found between elderly and younger patients.
✔️ Hepatic Impairment: Teana 20
- In patients with biliary obstructive disorders or hepatic insufficiency, Telmisartan should be administered carefully and with gradual dose increases.
✔️ Drug Interactions:
- NSAIDs: Concurrent use of NSAIDs may increase the risk of renal impairment and reduce the antihypertensive effect of Telmisartan.
- Aliskiren: Co-administration with Aliskiren is not recommended, especially in diabetic patients.
✔️ Contraindications:
- Hypersensitivity: Known allergy to Telmisartan or any of its components.
✔️ Pregnancy and Lactation:
- Pregnancy Category C in the first trimester and D in the second and third trimesters. It is not recommended during pregnancy due to potential harm to the fetus.
- If breastfeeding, a decision should be made whether to discontinue nursing or the drug, considering the mother's needs.
✔️ Precautions and Warnings:
- Fetal or Neonatal Exposure: Avoid use during pregnancy, especially during the second and third trimesters.
- Hypotension: Can cause low blood pressure, particularly after the first dose.
- Liver or Kidney Impairment: Use cautiously and monitor kidney and liver function.
- Avoid Combined Use with ACE Inhibitors: Using Telmisartan with an ACE inhibitor or other angiotensin receptor blockers should be avoided due to an increased risk of adverse effects.
✔️ Storage Conditions:
- Store below 30°C. Protect from light and moisture. Keep out of the reach of children.
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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