Bizoran 5/40mg 15pcs - ePharma
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Bizoran 5/40mg 15pcs

Type: Tablet

Pack Size: 15 Pcs

Generic Name: Amlodipine 5mg+ Olmesartan Medoxomil 40mg

Company Name: Beximco Pharmaceuticals Ltd.


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Discount Price: ৳ 282
MRP: ৳ 300 6% Off

⪼ Save  ৳: 18  in this Product


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✅ Description:

Indications

Bizoran 5/40 contains two medications that help control high blood pressure. Lowering your blood pressure lowers your chances of having a heart attack or stroke in the future. Bizoran 5/40 can be taken either on an empty stomach or with food. However, it is preferable to take it on a daily basis at the time prescribed by your doctor.

Pharmacology

Amlodipine is a dihydropyridine calcium channel blocker that can prevent calcium ions from crossing the blood-brain barrier and entering the vascular smooth muscle and myocardium. Amlodipine has a greater effect on vascular smooth muscle cells than on cardiomyocytes. Amlodipine is a peripheral arterial vasodilator that works directly on vascular smooth muscle to reduce peripheral vascular resistance and blood pressure.
Angiotensin II is created through a reaction catalyzed by the angiotensin-converting enzyme (ACE). It is a potent vasoconstrictor as well as the primary vasoactive hormone of the renin-angiotensin system. It is also a part of the pathophysiology to have high blood pressure. It also causes the adrenal cortex to produce aldosterone.
Olmesartan medoxomil inhibits angiotensin II vasoconstriction and aldosterone secretion by selectively blocking angiotensin II binding to AT1 receptors found in many tissues (such as vascular smooth muscle, and adrenal glands). Olmesartan Medoxomil is a reversible competitive inhibitor of the AT1 receptor, according to in vitro binding studies. Olmesartan medoxomil has no effect on ACE (kinase II, an enzyme that converts angiotensin I into angiotensin II and breaks down bradykinin).

Dosage & Administration

For patients on Bizoran, use individually titrated components. As needed, this combination may also be given with higher doses of Amlodipine, Olmesartan Medoxomil, or both.

Begin with 5/20 mg once daily for 1 to 2 weeks, then gradually increase to a maximum of 10/40 mg once daily. Due to decreased clearance of Amlodipine in elderly patients, the recommended starting dose of Amlodipine in patients 75 years old is 2.5 mg. Because the combination's lowest dose is 5/20 mg, initial therapy with this combination drug is not recommended in patients over the age of 75.

Interaction

Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the antihypertensive effects of angiotensin II receptor antagonists (including olmesartan medoxomil) (including selective COX2 inhibitors). Patients on combination therapy and other medications that affect RAS should have their blood pressure, kidney function, and electrolytes closely monitored.

Contraindications

Diabetes patients cannot be combined with Aliskiren.

Side-Effects

  • Sleepiness
  • Taste change
  • Ankle swelling
  • Headache
  • Flushing (sense of warmth in the face, ears, neck, and trunk)
  • Palpitations
  • Dizziness
  • Tiredness
  • Upset stomach
  • Increased potassium level in the blood

Pregnancy & Lactation

Pregnancy category D. The combination of amlodipine and olmesartan medoxomil should not be used in the second and third trimesters as it can cause fetal death. When pregnancy is detected, this combination should be stopped as soon as possible. It is not clear whether olmesartan and amlodipine are excreted in human milk. Due to the possible adverse effects of breastfeeding babies, the decision should be based on the importance of the drug to the mother whether to stop breastfeeding or to stop taking the drug.

Precautions & Warnings

The combination of amlodipine and olmesartan medoxomil should be used with caution because of the risk of volume hypotension or salt depletion. Vasodilation in patients with severe aortic stenosis. Increased frequency, duration, or severity of angina or acute Ml in patients with severe obstructive coronary artery disease.

Storage Conditions

Do not store above 30 ° C. Keep away from light and out of the reach of children.

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Check our pricing section for Bizoran 5/40mg 15pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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