Alphapress 1mg Tablet 1 Strip

✔️ Uses of Alphapress 1

Hypertension

✔️ Possible Side Effects

• Dizziness, drowsiness, headache, weakness, palpitations, nausea
• Gastrointestinal issues: Vomiting, diarrhea, constipation, abdominal discomfort
• Liver function abnormalities, pancreatitis
• Orthostatic hypotension, dyspnea, fainting, tachycardia
• Depression, hallucinations, nervousness, vertigo
• Skin reactions: Rash, pruritus, alopecia, lichen planus
• Urinary issues: Frequent urination, incontinence, impotence, priapism
• Vision changes, nasal congestion, tinnitus, dry mouth, excessive sweating

In rare cases, Prazosin has been linked to worsening pre-existing narcolepsy.

✔️ Dosage & Administration of Alphapress 1

Hypertension:

• Start with 0.5 mg at bedtime, then 0.5 mg twice or three times daily for 3-7 days.
• If well tolerated, increase to 1 mg twice or three times daily for another 3-7 days.
• The dose can be gradually increased to a maximum of 20 mg daily, divided into multiple doses.
• For patients on diuretics or other antihypertensive medications, initial doses should be lower to minimize excessive blood pressure reduction.

Left Ventricular Failure:

• Begin with 0.5 mg two to four times daily.
• Dosage should be gradually increased based on the patient's clinical response.
• Typical doses range from 4 mg to 20 mg daily in divided doses.

Raynaud’s Phenomenon & Raynaud’s Disease:

• Start with 0.5 mg twice daily for 3-7 days.
• Maintenance dose: 1-2 mg twice daily, with some patients requiring up to 2 mg three times daily.

Benign Prostatic Hyperplasia (BPH):

• Initial dose: 0.5 mg twice daily for 3-7 days.
• Maintenance dose: 2 mg twice daily.
• Daily doses exceeding 4 mg should be used cautiously.

Prazosin XR (Extended-Release Tablets):

• Initiate treatment with 2.5 mg once daily.
• Gradually increase the dose over 7-14 days based on response.
• Maximum studied dose: 20 mg once daily.

✔️ Prazosin has been safely used with various medications, including:

• Cardiac glycosides: Digitalis, Digoxin
• Hypoglycemic agents: Insulin, Chlorpropamide, Phenformin, Tolazamide, Tolbutamide
• Tranquilizers/Sedatives: Chlordiazepoxide, Diazepam, Phenobarbital
• Antiarrhythmic drugs: Procainamide, Propranolol, Quinidine
• Pain relievers & anti-inflammatory drugs: Aspirin, Indomethacin, Propoxyphene, Phenylbutazone

✔️ Contraindications

Prazosin is not recommended for individuals with known hypersensitivity to quinazolines.

✔️ Renal Impairment:

Initial dose should be 0.5 mg daily, with careful dose escalation.

✔️ Elderly Patients:

More susceptible to hypotension, so treatment should begin with the lowest possible dose.

✔️ Hepatic Dysfunction:

Therapy should start at 0.5 mg daily with gradual adjustments.

✔️ Pediatric Use

• Not recommended for children under 12 years due to lack of safety data.
• Left Ventricular Failure: Should not be used in cases involving mechanical obstructions such as aortic stenosis, mitral stenosis, pulmonary embolism, or restrictive pericardial disease.
• Limited data exists regarding its efficacy in patients with left ventricular failure following a recent heart attack.

✔️ Use During Pregnancy & Lactation

Pregnancy:

• Classified as Category C (use only if the benefits outweigh potential risks).
• Studies in pregnant women are limited, though no fetal abnormalities have been reported.

Lactation:

• Small amounts of Prazosin are excreted in breast milk.
• Caution is advised when prescribing to nursing mothers.

✔️ Warnings & Precautions

Hypertension:

• A small percentage of patients may experience sudden drops in blood pressure, particularly when initiating treatment.

To minimize this risk, therapy should begin with a low dose and increase gradually.

Left Ventricular Failure:

• Patients previously treated with diuretics or vasodilators may experience a sharp drop in blood pressure and cardiac output.
• Gradual dose titration is crucial.

Raynaud’s Disease & BPH:

• Patients should be closely monitored, particularly if they are already on blood pressure-lowering medications.

✔️ Storage Guidelines

Store in a cool, dry place below 30°C, away from light and moisture.

Keep out of reach of children.