Febuxit 80 Tablet 1 Strip

✔️ Uses of Febuxit 80

Treatment of Gout

✔️ Dosage & Administration of Febuxit 80

Chronic Gout Management:

Start with 40 mg once daily.

If serum uric acid remains ≥6 mg/dL after 2 weeks, increase to 80 mg once daily.

If needed, escalate to 120 mg once daily after 2–4 weeks.

Tumor Lysis Syndrome (TLS):

Recommended dose: 120 mg once daily, starting 2 days before initiating chemotherapy.

Continue for at least 7 days, or up to 9 days based on the chemotherapy regimen.

Managing Gout Flares:

Flares may occur early in treatment due to shifting uric acid levels.

Use NSAIDs or colchicine for flare prevention when starting Febuxit.

Continue Febuxit during flares; manage symptoms as needed.

Special Populations:

Renal Impairment (mild–moderate): No dose adjustment needed.

Hepatic Impairment (mild–moderate): No dose adjustment required.

Pediatrics: Not established for use in patients under 18 years of age.

✔️ Drug Interactions

Contraindicated:

Azathioprine, Mercaptopurine, Theophylline – due to the risk of severe toxicity.

Cautionary/Monitoring:

Naproxen/NSAIDs/Probenecid: May affect Febuxit metabolism via UGT inhibition.

UGT Inducers: Can reduce Febuxit efficacy – monitor uric acid levels.

Rosiglitazone (CYP2C8 substrates): No dose change needed.

Antacids: May delay absorption, but do not reduce overall exposure.

Safe Co-administration (No dose adjustment needed):

• Colchicine
• Indomethacin
• Hydrochlorothiazide
• Warfarin

✔️ Side Effects of Febuxit 80

Common side effects include:

Gout flares, liver enzyme elevation, nausea, diarrhea, headache, rash, and edema
Rare cases of serious allergic reactions have been reported.

✔️ Use in Pregnancy & Lactation

Pregnancy Category C: Use only if the potential benefit justifies the potential risk.

Lactation: Unknown if excreted in human milk – use caution in nursing women.

✔️ Precautions & Warnings

Gout Flares: Expected during early therapy; continue Febuxit and treat flares as appropriate.

Cardiovascular Risk: Slightly higher rates of thromboembolic events (e.g., MI, stroke) noted in studies – monitor closely.

Liver Monitoring: Periodically assess liver function during treatment.

✔️ Contraindications:

Hypersensitivity to Febuxostat

Concurrent use of azathioprine, mercaptopurine, or theophylline

✔️ Storage Conditions

Store below 30°C, protected from light and moisture.
Keep out of reach of children.