Xeldrin 20mg Capsule

✔️ Uses of Xeldrin 20mg Capsule

• Gastroesophageal Reflux Disease
• Zollinger-Ellison Syndrome
• Duodenal Ulcer
• Helicobacter Pylori Infection
• Erosive Esophagitis

✔️ How does Xeldrin 20mg Capsule work?

Xeldrin 20mg Capsule reduces the quantity of acid generated in the stomach by permanently adhering to and blocking the hydrogen-potassium ATPase pump found on the digestive tract's lining. This type of activity aids in the reduction of vomiting and the mending of damaged stomach tissue in ulcers.

✔️ Side Effects of Xeldrin 20mg Capsule

• Stomach pain
• Gas formation (flatulence)
• Nausea
• Vomiting
• Diarrhea
• Headache

✔️ Quick Suggestions:

• Avoid eating late at night or before bedtime: Eating close to bedtime can trigger symptoms of acid reflux. It is advisable to have your last meal at least 2-3 hours before lying down.
• Inform your doctor about persistent symptoms: If you experience watery diarrhea, fever, or stomach pain that does not go away while taking Xeldrin 20mg, it is important to inform your doctor as these could be signs of a more serious condition that requires attention.
• Long-term use and bone health: Prolonged use of Xeldrin 20 can lead to weakened bones and mineral deficiencies, such as magnesium. It is recommended to ensure an adequate intake of calcium and magnesium through diet or supplements as prescribed by your doctor.
• Avoid trigger foods and drinks: Acid or heartburn-triggering foods and drinks, such as onions, peppermint, chocolate, citrus fruits or juices, tomatoes, high-fat, and spicy foods, should be avoided to minimize symptoms.
• Elevation while sleeping: Elevating the head and chest by raising the bedhead or using a single raised block can help prevent stomach acid from flowing back into the food pipe during sleep.
• Avoid alcohol and smoking: Alcohol consumption can increase the production of stomach acid, leading to heartburn and acid reflux. Smoking damages the valve that prevents acid reflux. It is advisable to avoid alcohol and smoking.
• Include beneficial foods: Incorporate high-fiber foods, berries, cherries, leafy green vegetables (kale, spinach), and black peppers into your diet. These foods are rich in antioxidants, calcium, and vitamin B12, which can help mitigate the long-term effects of the medication. Probiotic-rich fermented dairy products like miso, sauerkraut, and kimchi can aid in preventing excessive stomach acid production. Cranberry juice may be beneficial in managing peptic ulcers and H. pylori infections.
• Avoid prolonged sitting: Taking regular breaks from sitting and engaging in brisk walking or stretching every hour can help reduce stomach acid production.
• Do not stop medication without consulting your doctor: It is important to continue taking Xeldrin 20 as prescribed and not discontinue the medication without consulting your doctor.
• Watch out for kidney-related symptoms: If you experience decreased urination, edema (swelling), lower back pain, nausea, fatigue, rash, or fever, it is essential to consult your doctor promptly as these could be signs of a kidney problem.

✔️ Indication

Omeprazole is used to treat 

• Ulcers in the stomach and duodenum: Xeldrin 20mg Capsule helps in healing and preventing the recurrence of ulcers in the stomach and the upper part of the intestine (duodenum).
• Duodenal and stomach ulcers caused by NSAIDs: Xeldrin 20mg Capsule can be used as a preventive measure in patients with a history of ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs).
• Gastro-esophageal reflux disease (GERD): Xeldrin 20mg Capsule is effective in treating GERD, a condition in which stomach acid flows back into the esophagus, causing symptoms such as heartburn, nausea, vomiting, and discomfort in the upper abdomen.
• Acid reflux disease management over time: Xeldrin 20mg Capsule is used for the long-term management of acid reflux disease, helping to reduce symptoms and prevent complications.
• Dyspepsia caused by stomach acid: Xeldrin 20mg Capsule can provide relief from dyspepsia, a condition characterized by indigestion, stomach discomfort, and pain caused by excessive stomach acid.
• Reflux esophagitis with ulcers: Xeldrin 20mg Capsule is effective in treating reflux esophagitis, a condition in which the lining of the esophagus becomes inflamed and develops ulcers due to acid reflux.
• Acid aspiration prevention during general anesthesia: Xeldrin 20mg Capsule may be used to reduce the risk of acid aspiration, a condition where stomach acid enters the airways, during general anesthesia.

✔️ Pharmacology

Omeprazole, a substituted benzimidazole, is a stomach acid secretion inhibitor. It reduces gastric acid output by inhibiting the ATPase H + / K + enzyme system in the parietal cells of the stomach. After oral administration, the antisecretory action begins in one hour, peaks in two hours, and the suppression of secretion lasts up to 72 hours. After discontinuing the medicine, secretory activity will gradually return over the next 3-5 days.

✔️ Dosage & Administration of Xeldrin 20mg Capsule

For different conditions, the recommended doses of Xeldrin  (Omeprazole) are as follows:

Benign gastric and duodenal ulcer:

• 20 mg once daily for 4 weeks in duodenal ulceration
• 8 weeks in gastric ulceration
• In severe or recurrent cases, the dose can be increased to 40 mg daily
• The maintenance dose for recurrent duodenal ulcer is 20 mg once daily
• In the prevention of relapse in duodenal ulcer, the dose is 10-20 mg daily

NSAID-associated duodenal or gastric ulcer:

• 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
• 20 mg once daily is used as prophylaxis in patients with a history of NSAID-associated duodenal or gastric ulcers

Gastro-esophageal reflux disease (GERD):

• 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed
• 40 mg once daily has been given for 8 weeks in GERD refractory to other treatment
• The maintenance dose is 20 mg once daily

Long-term management of acid reflux disease:

• 10-20 mg daily

Acid-related dyspepsia:

• 10-20 mg once daily for 2-4 weeks

Prophylaxis of acid aspiration:

• 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery

Zollinger-Ellison syndrome:

• Initially 60 mg once daily, with a usual range of 20-120 mg daily (if the daily dose is more than 80 mg, divided doses should be used)

Helicobacter pylori eradication regimen in peptic ulcer disease:

• Omeprazole 20 mg twice daily in association with antimicrobial agents as prescribed by the doctor

Pediatric use in severe ulcerating reflux esophagitis (Child > 1 year):

• If body weight is 10-20 kg, 10-20 mg once daily for 4-12 weeks
• If body weight is over 20 kg, 20-40 mg once daily for 4-12 weeks

Take Xeldrin 20mg Capsule as advised by your physician. Swallow Xeldrin 20mg Capsule with a glass of water. Do not crush or chew the medicine. Please note that these dosage recommendations are general guidelines, and the actual dosage may vary depending on the individual's condition and the doctor's discretion. It is important to follow the dosage instructions provided by your healthcare professional.

✔️ Interaction

Xeldrin 20mg Capsule may interact with several medications and conditions. Here are the key interactions to be aware of:

1. Medication interactions: Xeldrin 20mg Capsule  may interact with the following medications:
   • Blood thinners: Clopidogrel and Warfarin.
   • Antifungal drugs: Ketoconazole, voriconazole, itraconazole, and posaconazole.
   • Anti-HIV drugs: Atazanavir and nelfinavir.
   • Iron supplements.
   • Antibiotics: Ampicillin and rifampicin.
   • Heart medicine: Digoxin.
   • Anti-cancer drug: Methotrexate.

It is important to inform your doctor about all the medications you are taking, including over-the-counter drugs, supplements, and herbal products, to avoid any potential interactions.

Food interactions: Xeldrin 20mg Capsule may interact with St. John's wort, a plant used as an antidepressant. Avoid taking St. John's wort along with Xeldrin 20mg Capsule, as it may affect the effectiveness of the medication.

Disease interactions: Xeldrin 20mg Capsule should not be given in patients with the following conditions:

• C. difficile-induced colitis.
• Liver disease.
• Bone fractures.
• Low vitamin B12 levels (anemia).
• Low magnesium levels (hypomagnesemia).

✔️ Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.

✔️ Pregnancy & Lactation

It is important to note that the use of Omeprazole during pregnancy should be based on careful consideration of the potential benefits and risks, and it should be used only if clearly needed and under the supervision of a healthcare professional.

If you are pregnant or planning to become pregnant, it is recommended to consult with your doctor for a thorough evaluation and discussion of the potential risks and benefits of using Omeprazole in your specific situation.

✔️ Precautions & Warnings

• Clostridium difficile-associated Diarrhea: Xeldrin 20mg Capsule should not be given to patients suffering from this condition.
• Pregnancy and breastfeeding: Xeldrin 20mg Capsule is generally considered safe for pregnant and breastfeeding mothers, but it should be taken only after consulting with a doctor.
• Pre-existing conditions: Inform your doctor if you have stomach or intestinal cancer, liver problems, or if you are allergic to Xeldrin 20mg Capsule.
• Endoscopy: If you are scheduled to have an endoscopy in the future, it is important to discuss with your doctor whether you should stop taking Xeldrin 20mg Capsule a few weeks before the procedure. This is because the medication may mask certain problems that would otherwise be detected during the endoscopy.
• Risk of fractures: Prolonged use of Xeldrin 20mg Capsule may be associated with an increased risk of osteoporosis-related fractures, particularly in the hip, wrist, or spine. This risk is related to the potential loss of magnesium. It is important to discuss this risk with your doctor and ensure adequate intake of calcium and magnesium through diet or supplements as prescribed.
• Drug interactions: Avoid using Xeldrin 20mg Capsule with St. John's Wort (a plant-based antidepressant), rifampin (an antibiotic), and methotrexate (used for cancer and arthritis treatment) due to the potential for severe drug interactions. It is important to inform your doctor about all medications you are taking to avoid any adverse effects or interactions.

✔️ Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.