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Vonliv 20 Tablet 1 Strip
Vonliv is prescribed for the treatment and prevention of various acid-related gastrointestinal conditions, including:
- Gastric ulcers
- Duodenal ulcers
- Reflux esophagitis
- Prevention of ulcer recurrence in patients taking low-dose aspirin or NSAIDs
- Helicobacter pylori eradication therapy (in combination with antibiotics) for:
- Gastric and duodenal ulcers
- Gastric MALT lymphoma
- Idiopathic thrombocytopenic purpura
- H. pylori gastritis or post-endoscopic resection of early gastric cancer
Use only as directed by a registered physician
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✅ Description:
Vonliv
Generic Name: Vonoprazan
Therapeutic Class: Potassium-Competitive Acid Blocker (P-CAB)
Dosage Forms: Tablet
Vonoprazan is a Potassium-Competitive Acid Blocker (P-CAB) that reversibly inhibits the H+, K+-ATPase enzyme in gastric parietal cells. Unlike PPIs, Vonliv does not require acid activation, allowing for rapid onset and sustained acid suppression. It binds directly and competitively with the proton pump, reducing gastric acid secretion and promoting mucosal healing.
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✔️ Common Side Effects
Gastrointestinal: Diarrhea, constipation, nausea, bloating
Skin: Rash, urticaria, hypersensitivity reactions
Liver: Elevated liver enzymes (AST, ALT, ALP, γ-GTP), jaundice, abnormal liver function tests
Others: Edema, eosinophilia, fatigue
Rare but serious:
Anaphylactic reactions
Drug eruption
✔️ Dosage & Administration
Gastric Ulcer:
- 20 mg once daily for 8 weeks
Duodenal Ulcer:
- 20 mg once daily for 6 weeks
Reflux Esophagitis:
- 20 mg once daily for 4–8 weeks, based on response
Maintenance therapy: 10 mg once daily (can be increased to 20 mg if needed)
Ulcer Prevention with NSAIDs or Aspirin:
- 10 mg once daily
H. pylori Eradication Therapy:
First-line regimen (7 days):
- Vonliv 20 mg + Amoxicillin 750 mg + Clarithromycin 200–400 mg, all taken twice daily
Second-line regimen (7 days) for clarithromycin failure:
- Vonliv 20 mg + Amoxicillin 750 mg + Metronidazole 250 mg, all taken twice daily
Elderly:
- Use with caution due to the potential decline in hepatic or renal function
Children (<18 years):
Safety and efficacy not established; not recommended
Renal Impairment:
- Mild to Moderate (eGFR 30–89 mL/min): No dose adjustment required
- Severe (eGFR <30 mL/min): Avoid use
Hepatic Impairment:
- Mild (Child-Pugh A): No adjustment needed
- Moderate to Severe (Child-Pugh B or C): Avoid use
Administration Note:
Vonliv can be taken with or without food. Take at the same time daily for optimal effect.
✔️ Management of Gastrointestinal problems such as:
- GERD and its signs, like heartburn, acidity, iand ndigestion
- Reflux or erosive esophagitis
- Stomach ulcers and duodenal ulcers
- Adjunctive therapy for H. pylori infection in combination with antibiotics
✔️ Contraindications
Known hypersensitivity to Vonoprazan or its excipients
Concomitant use with:
- Atazanavir sulfate
- Nelfinavir
- Rilpivirine hydrochloride
✔️ Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus
Lactation: Not recommended during breastfeeding. If necessary, discontinue nursing during treatment
✔️ Precautions & Warnings
- Limit treatment duration to the shortest effective period based on the disease condition
- Long-term use should be monitored via endoscopy if necessary
- Maintenance therapy for reflux esophagitis should only be used in patients with recurrent or relapsing disease
- Consider dose reduction (from 20 mg to 10 mg) or cessation once healing is sustained
✔️ Storage Conditions
Store below 30°C in a cool, dry place, protected from light
Keep out of reach of children
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