Xevon 20 Tablet 1 Strip

✔️ Side Effects

The following side effects have been reported with the use of Xevon: Diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea, abdominal distension, increased gamma-glutamyl transferase, increased AST, abnormal liver function test, ALT increased, ALP increased, LDH, increased y-GPT, edema, and eosinophilia

✔️ Vonoprazan is contraindicated in:

• Patients with hypersensitivity to Vonoprazan or to any excipient of the product.
• Patients receiving atazanavir sulphate, nelfinavir, or rilpivirine hydrochloride.

✔️ Use in the elderly:

Since the physiological functions, such as hepatic or renal function, are decreased in elderly patients in general, Xevon should be carefully administered.

✔️ Use in children less than 18 years of age:

The safety and efficacy of Xevon in children and adolescents have not been established. Therefore, the administration of Xevon is not recommended in children and adolescents below 18 years of age.

✔️ Patients with hepatic impairment:

No dose adjustment of Xevon is recommended in patients with mild hepatic impairment (Child-Pugh A). Avoid the use of Xevon in patients with moderate to severe hepatic impairment (Child-Pugh B or C).

✔️ Patients with renal impairment:

No dose adjustment of Xevon is recommended in patients with mild to moderate renal impairment (eGFR 30 to 89 mL/min). Avoid the use of Xevon in patients with severe renal impairment (eGFR < 30 mL/min)

✔️ Pregnancy & Lactation

Vonoprazan should be used in pregnant women or women having possibility of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk. It is advisable to avoid the administration of Vonoprazan to nursing mothers. However, when the administration is indispensable, nursing should be discontinued.

✔️ Precautions & Warnings

During the treatment, the course of the disease should be closely observed, and the minimum therapeutic necessity should be used according to the disease condition. In the long-term, treatment with Xevon, close observation by such means as endoscopy should be made.

In the maintenance of healing of reflux esophagitis, Xevon should be administered only to patients who experience repeated recurrence and recrudescence of the condition. Administration to the patients who do not necessitate maintenance of healing should be avoided.

When the healing is maintained over a long period and when there is no risk of recurrence, the dose reduction to a dose of 10mg from a dose of 20mg, or suspension of administration, should be considered.

✔️ Storage:

Store below 30°C, in a cool and dry place. Keep away from light. Keep all the medicine out of the reach of children.