Xorel 20mg Tablet 10Pcs

Uses of Xorel 20 Tablet

• Gastroesophageal reflux disease (Acid reflux)
• Peptic ulcer disease

How to use Xorel 20 Tablet

• Take this medicine in the dose and duration as advised by your doctor.
• Swallow it as a whole.
• Do not chew, crush or break it.
• Xorel 20 Tablet is to be taken empty stomach.

How Xorel 20 Tablet works

Xorel 20 Tablet is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

What if you forget to take Xorel 20 Tablet?

If you miss a dose of Xorel 20 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Side effects of Xorel 20 Tablet

• Diarrhea
• Dizziness
• Flatulence
• Headache
• Nausea
• Sore throat
• Stomach pain
• Vomiting

Quick Suggestions:

• It is a well-tolerated medicine and provides relief for a long time.
• Avoid eating late at night or before bedtime.
• Maintain a healthy weight by regular exercising.
• Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
• Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
• Long-term use of Xorel 20 Tablet can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or supplements as prescribed by your doctor.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
• Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Indications of Xorel 20 Tablet

• Healing of Erosive or Ulcerative GERD
• Maintenance of Healing of Erosive or Ulcerative GERD
• Treatment of Symptomatic GERD
• Healing of Duodenal Ulcers
• Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence
• Treatment of Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome 

Pharmacology

Rabeprazole reduces gastric acid production by inhibiting the gastric H+/K+-ATPase at the secretory membrane of the gastric parietal cell. Because this enzyme is thought to be the acid (proton) pump within the parietal cell, rabeprazole has been classified as a gastric proton-pump inhibitor.

Dosage & Administration of Xorel 20 Tablet

Healing of Erosive or Ulcerative GERD: 

• The recommended adult oral dose is Xorel-20 to be taken once daily for four to eight weeks. For those patients who have not healed after 8 weeks of treatment, an additional 8-week course of Xorel-20 may be considered.

Maintenance of Healing of Erosive or Ulcerative GERD:

• The recommended adult oral dose is one Xorel-20 once daily.

Treatment of Symptomatic GERD:

• The recommended adult oral dose is one Xorel-20 tablet once daily for 4 weeks. If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered.

Healing of Duodenal Ulcers:

• The recommended adult oral dose is one Xorel-20 once daily after the morning meal for a period of up to 4 weeks. Most patients with duodenal ulcers heal within 4 weeks. A few patients may require additional therapy to achieve healing.

Treatment of Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome:

• The dosage of Xorel-20 in patients with pathological hypersecretory conditions varies with the individual patient.
• The recommended adult oral starting dose is 60 mg once a day.
• Doses should be adjusted to individual patient's needs and should continue for as long as clinically indicated.
• Some patients may require divided doses.
• Some patients with Zollinger-Ellison syndrome have been treated continuously with Xorel-20 for up to one year.

Interaction

Rabeprazole, like other PPIs, is metabolized by the drug-metabolizing enzyme system Cytochrome P450. However, there is no clinically significant interaction between rabeprazole and other drugs metabolized by the CYP P450 system, such as warfarin, theophylline, diazepam, and phenytoin. Rabeprazole inhibits gastric acid secretion and may interfere with the absorption of drugs whose bioavailability is determined by gastric pH, such as ketoconazole, iron salts, and digoxin. There was no interaction with liquid antacids or foods observed in studies.

Contraindications

Rabeprazole is contraindicated in patients with known hypersensitivity to Rabeprazole or to any component of the formulation.

Pregnancy & Lactation

Pregnancy category B. There are no adequate well-controlled studies on pregnant women. This drug should be used during pregnancy only if clearly needed.

Use in Nursing Mother:

Given that many medications are excreted in milk and that Rabeprazole may produce harmful effects in nursing infants, a choice should be made regarding whether to stop breastfeeding or stop the medication, taking into account the significance of the medication to the mother.

Precautions & Warnings

• Administration of Rabeprazole to patients with mild to moderate liver impairment results in increased exposure and decreased elimination. Caution should be exercised in patients with severe hepatic impairment.
• Inform your doctor before taking Xorel 20mg Tablet if you are due to have Chromogranin A blood test.
• Xorel 20mg  Tablet may cause abnormal blood and liver enzyme values. Inform the person doing the tests that you are taking Xorel 20mg

Storage Conditions

Store in a cool and dry place, and protect from light.