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Vonozan – For Effective Acid Suppression
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✅ Description:
Vonozan is a potassium-competitive acid blocker (P-CAB) that directly inhibits H+, K+-ATPase in gastric parietal cells without needing acid activation. It remains localized at the acid-secreting site, offering potent and sustained acid suppression, and helps prevent upper GI mucosal injury.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Vonozan is prescribed for managing:
- Gastric and duodenal ulcers
- Reflux esophagitis
- Prevention of ulcer recurrence during use of low-dose aspirin or NSAIDs
- As part of triple therapy for Helicobacter pylori eradication in gastric/duodenal ulcers, MALT lymphoma, ITP, post-endoscopic gastric cancer resection, or H. pylori gastritis
✔️ Dosage & Administration
- Gastric ulcer: 20 mg once daily for 8 weeks
- Duodenal ulcer: 20 mg once daily for 6 weeks
- Reflux esophagitis: 20 mg once daily for 4–8 weeks
- Maintenance of esophagitis: 10 mg once daily (may increase to 20 mg if necessary)
- Ulcer prevention (aspirin/NSAID): 10 mg once daily
H. pylori eradication:
First-line: Vonozan 20 mg + Amoxicillin 750 mg + Clarithromycin 200 mg – twice daily for 7 days
Second-line (if needed): Vonozan 20 mg + Amoxicillin 750 mg + Metronidazole 250 mg – twice daily for 7 days
Can be taken with or without food.
Elderly: Use with caution due to potential organ function decline
Children under 18: Not recommended (safety not established)
Renal Impairment:
Mild–Moderate (eGFR 30–89): No dose change
Severe (eGFR <30): Avoid use
Hepatic Impairment:
Mild (Child-Pugh A): No adjustment needed
Moderate–Severe (Child-Pugh B/C): Avoid use
✔️ Common adverse effects include:
- Gastrointestinal: Diarrhea, constipation, nausea, abdominal bloating
- Liver-related: Elevated liver enzymes (AST, ALT, GGT, ALP), jaundice
- Others: Rash, urticaria, edema, drug hypersensitivity, eosinophilia
✔️ Contraindications
Hypersensitivity to Vonoprazan or any excipients
Concurrent use with Atazanavir, Nelfinavir, or Rilpivirine
✔️ Use in Pregnancy & Lactation
Vonozan should only be used during pregnancy if the benefits outweigh potential risks. If necessary during breastfeeding, consider stopping nursing.
✔️ Precautions & Warnings
- Use the lowest effective dose based on disease severity.
- In long-term use, monitor with endoscopy.
- Reserve maintenance therapy for patients with recurrent esophagitis.
- Consider dose reduction or discontinuation if healing is sustained.
✔️ Storage:
Store below 30°C in a dry, cool, and light-protected place. Keep away from children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
