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Emep MUPS 40mg Tablet 10pcs
MUPS (Multiple-Unit Pellet System) technology combines the advantages of tablets and pellet-filled capsules:
- Ensures greater bioavailability.
- Promotes uniform emptying of micro-pellets from the stomach to the intestine for faster drug release.
- Reduces dose-dumping risks and minimizes local irritation.
- Offers consistent and controlled pharmacological action with once-daily dosing.
- Improves drug absorption and minimizes plasma concentration fluctuations.
- Provides better esophageal residence time reduction compared to capsules.
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✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Emep MUPS is indicated for:
- Gastro-esophageal Reflux Disease (GERD)
- Risk reduction of NSAID-associated gastric ulcers
- H. pylori eradication (as part of triple therapy)
- Zollinger-Ellison syndrome and idiopathic hypersecretion
Use as directed by a registered physician.
✔️ Pharmacology
Esomeprazole, a proton pump inhibitor, blocks the hydrogen-potassium ATPase enzyme system (proton pump) in gastric parietal cells, effectively reducing gastric acid secretion. It is used for the short-term treatment of gastric and duodenal ulcers and for preventing NSAID-induced gastric ulcers.
✔️ Dosage & Administration
Erosive Esophagitis
- Adults (≥18 years): 40 mg once daily for 4 weeks.
- Children (12-18 years): 40 mg once daily for 4 weeks.
Maintenance of Healing (Erosive Esophagitis)
- Adults (≥18 years): 20 mg once daily.
- Children (12-18 years): 20 mg once daily.
Risk Reduction of NSAID-associated Gastric Ulcers
- Adults (≥18 years): 20 mg once daily for 4-8 weeks.
H. pylori Eradication (with Amoxicillin and Clarithromycin)
- Adults (≥18 years): 20 mg twice daily for 7 days.
- Children (12-18 years): 20 mg twice daily for 7 days.
Zollinger-Ellison Syndrome & Idiopathic Hypersecretion
- Adults (≥18 years): 40-80 mg twice daily.
Children (1-11 years)
- Erosive esophagitis:
- <20 kg: 10 mg once daily for 8 weeks.
- ≥20 kg: 10-20 mg once daily for 8 weeks.
- Maintenance: 10 mg once daily.
Not approved for children below 1 year.
✔️ Administration
- Swallow the tablets whole with liquid.
- Do not chew or crush the tablets.
- Alternatively, disperse the tablet in half a glass of non-carbonated water (not mineral water). Stir until disintegrated, drink immediately, and rinse the glass with more water to ensure full dose intake.
✔️ Interactions
- Metabolism: Primarily metabolized by CYP2C19 and CYP3A4.
- CYP Interactions: No clinically significant interactions with CYP1A2, 2A6, 2C9, 2D6, or 3A4.
- Drug Absorption: This may affect drugs dependent on gastric pH for absorption (e.g., ketoconazole, iron salts, digoxin).
- Combination Therapy: Increases plasma levels of Emep MUPS and 14-hydroxy clarithromycin when co-administered with clarithromycin and amoxicillin.
✔️ Side Effects
Common side effects include:
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
No significant differences in side effects were observed between short-term and maintenance treatment (up to 12 months).
✔️ Use During Pregnancy & Lactation
- Use with caution during pregnancy.
- It is unclear if Esomeprazole or its metabolites are excreted in human breast milk.
✔️ Contraindications
- Known hypersensitivity to Esomeprazole or any component of the formulation.
✔️ Precautions & Warnings
- Use cautiously in patients with severe liver or renal impairment.
- Prolonged use (>1 year) may increase the risk of fractures (hip, wrist, spine).
✔️ Storage Conditions
- Store below 25°C in a cool, dry place.
- Protect from light.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
