Voriderm 200 | 10 Pcs
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Voriderm 200 | 10 Pcs

Generic: Voriconazole

Type: Tablet

Pack Size: 10 Pcs

Voriconazole | Azole Antifungal
Available as: Tablets, Oral Suspension, and Injection
For patients ≥12 years

Voriconazole is a broad-spectrum triazole antifungal that inhibits fungal ergosterol synthesis, an essential component of the fungal cell membrane. It acts through inhibition of CYP450-dependent 14-alpha sterol demethylase, resulting in cell membrane dysfunction and fungal death.

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✅ Description:

Voriderm is indicated in the treatment of serious and potentially life-threatening fungal infections, including:

  • Invasive aspergillosis
  • Candidemia in non-neutropenic patients and deep-seated candidiasis involving organs like skin, abdomen, kidney, bladder wall, or surgical wounds
  • Esophageal candidiasis
  • Severe infections caused by Scedosporium apiospermum and Fusarium species (including Fusarium solani)
  • Infections in patients refractory to or intolerant of alternative antifungal therapies
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✔️ Use in Special Populations

Pregnancy: Use only if clearly needed. May pose fetal risks (category not explicitly defined).

Lactation: Use only when benefits outweigh risks.

Children <12 years: Safety and efficacy not established.

Elderly: No dosage adjustment necessary unless liver/renal impairment is present.

✔️ Dosage & Administration: Oral Formulation

To be taken 1 hour before or after meals

≥40 kg body weight

Loading dose: 400 mg (10 ml) every 12 hours for the first 24 hours

Maintenance dose: 200 mg (5 ml) twice daily

<40 kg body weight

Loading dose: 200 mg (5 ml) every 12 hours for the first 24 hours

Maintenance dose: 100 mg (2.5 ml) twice daily

Or as prescribed by a registered physician

✔️ Drug Interactions
  • Inhibitors or inducers of CYP3A4, CYP2C9, and CYP2C19 may affect voriconazole levels. Monitor for toxicity or reduced efficacy.
  • May increase blood levels of drugs metabolized by CYP enzymes — dose adjustment required.
  • Phenytoin or Efavirenz: Voriconazole dose may need to be increased.
  • Avoid co-administration with:
  • Terfenadine, cisapride, pimozide, quinidine, astemizole (risk of QT prolongation)
  • Rifampin, carbamazepine, long-acting barbiturates, ritonavir, ergot alkaloids, St. John's Wort
✔️ Common Side Effects

Gastrointestinal: Nausea, abdominal pain, diarrhea

Visual disturbances: Blurred vision

Nervous system: Headache

Others: Anemia, chest pain

✔️ Contraindications

Known hypersensitivity to voriconazole or any component

Concurrent use of medications listed above may cause life-threatening adverse reactions

✔️ Warnings & Precautions

Use with caution in long-term therapy (≥180 days); increased risk of cutaneous squamous cell carcinoma (SCC) has been reported.

Regular monitoring of liver function, visual disturbances, and dermatologic reactions is advised.

Adjust dose and monitor with CYP-metabolized drugs.

Use caution in hepatic and renal dysfunction.

✔️ Storage Conditions
  • Store tablets and injection below 25°C, protected from light and moisture
  • Store dry powder for suspension at 2°C–8°C
  • Keep out of reach of children
Frequently Asked Questions (FAQ)

Voriderm 200 is an antifungal medication used to treat serious fungal infections, including invasive aspergillosis, candidaemia, and invasive Candida species infections. It is also used in high-risk patients, such as those undergoing bone marrow transplantation, to prevent or treat fungal complications.

This medication is not recommended during pregnancy unless your doctor deems it absolutely necessary. Speak with your doctor if you are pregnant, planning to conceive, or breastfeeding.

Voriderm 200 is not suitable for individuals allergic to voriconazole or its ingredients. It should also be avoided with certain medications (like rifampin, carbamazepine, or ergot alkaloids) due to serious interaction risks.

No. Stopping early can lead to a return or worsening of the infection. Always finish the full course unless your doctor advises otherwise.

No. Higher doses do not increase effectiveness and may lead to serious side effects or toxicity. If you or someone else takes too much, seek medical attention immediately.

Voriderm 200 is generally well-tolerated when used as prescribed. However, long-term use (over 180 days) may require regular monitoring due to potential risks such as skin cancer or liver issues. Always consult your physician before continuing long-term.

If you miss a dose, take it as soon as you remember. If it’s nearly time for your next dose, skip the missed one. Do not double the dose to catch up.

Voriderm 200 belongs to the triazole class of antifungals. It works by inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane. Without ergosterol, the fungus cannot grow or survive, effectively stopping the spread of the infection.

The duration of treatment depends on your age, weight, and the severity of infection. Always complete the full course as prescribed by your doctor, even if you start to feel better.

Take the tablet 1 hour before or 1 hour after meals. Swallow whole with a glass of water—do not crush, chew, or break the tablet. Follow your doctor’s exact dosage instructions.
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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

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