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Osapiderm DR 100mg Tablet | Box
Active substance: Posaconazole, a triazole antifungal.
Mechanism: Blocks ergosterol synthesis by inhibiting lanosterol 14-α-demethylase (CYP450 enzyme).
Effect: Leads to ergosterol depletion and accumulation of toxic sterol precursors, weakening fungal cell membranes → cell death.
Discount
Price: ৳ 1,880
MRP:
৳
2000
6%
Off
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Cash on Delivery - All over Bangladesh
Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Osapiderm is indicated for patients aged 13 years and above in the treatment of:
- Invasive Aspergillosis – in patients refractory or intolerant to Amphotericin B or Itraconazole.
- Fusariosis – in patients refractory or intolerant to Amphotericin B.
- Chromoblastomycosis and Mycetoma – in patients refractory or intolerant to Itraconazole.
- Coccidioidomycosis – in patients refractory or intolerant to Amphotericin B, Itraconazole, or Fluconazole, or who cannot tolerate these drugs.
- Also indicated for prophylaxis of invasive fungal infections in:
- Patients receiving remission-induction chemotherapy for Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndromes (MDS) with expected prolonged neutropenia.
- Hematopoietic Stem Cell Transplant (HSCT) recipients undergoing high-dose immunosuppressive therapy for graft-versus-host disease.
👉 Refractoriness is defined as infection progression or no improvement after ≥7 days of effective antifungal therapy.
👉 Use only under the supervision of a registered physician.
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✔️ Dosage & Administration | Osapiderm DR 100
Form: Tablet
Administration: Swallow whole with water, with or without food. Do not crush or chew.
Loading Dose (Day 1): 300 mg (3 tablets) twice daily.
Maintenance Dose (Day 2 onwards): 300 mg (3 tablets) once daily.
Duration: Based on disease severity, immunosuppression recovery, and clinical response.
Pediatrics (<13 years): Not recommended (safety not established).
Geriatrics: No dose adjustment required.
Hepatic Impairment: Use with caution; monitor liver function.
Renal Impairment:
Mild–moderate: No adjustment.
Severe: Monitor closely for fungal breakthrough.
✔️ Side Effects | Osapiderm DR 100
Gastrointestinal: Diarrhea, nausea, vomiting
Systemic: Fever, headache, cough
Laboratory: Hypokalemia
✔️ Drug Interactions
CYP3A4 Inhibition: May increase plasma levels of drugs metabolized by CYP3A4 (e.g., Midazolam, Alprazolam, Triazolam).
Avoid co-administration with:
Rifamycins (Rifampicin, Rifabutin)
Anticonvulsants (Phenytoin, Carbamazepine, Phenobarbital, Primidone)
Efavirenz
Contraindicated with ergot alkaloids, certain QT-prolonging drugs (Cisapride, Pimozide, Quinidine, Terfenadine, Astemizole, Halofantrine), and statins (Simvastatin, Lovastatin, Atorvastatin).
✔️ Contraindications
Hypersensitivity to Posaconazole or other azoles.
Concomitant use with drugs that can cause serious QT prolongation or rhabdomyolysis (see above).
✔️ Pregnancy & Lactation
Pregnancy: Not recommended unless benefits outweigh risks.
Lactation: Discontinue breastfeeding during therapy.
✔️ Storage:
Store below 25°C.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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