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Osapiderm DR 100mg Tablet | Box
Active substance: Posaconazole, a triazole antifungal.
Mechanism: Blocks ergosterol synthesis by inhibiting lanosterol 14-α-demethylase (CYP450 enzyme).
Effect: Leads to ergosterol depletion and accumulation of toxic sterol precursors, weakening fungal cell membranes → cell death.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Osapiderm is indicated for patients aged 13 years and above in the treatment of:
- Invasive Aspergillosis – in patients refractory or intolerant to Amphotericin B or Itraconazole.
- Fusariosis – in patients refractory or intolerant to Amphotericin B.
- Chromoblastomycosis and Mycetoma – in patients refractory or intolerant to Itraconazole.
- Coccidioidomycosis – in patients refractory or intolerant to Amphotericin B, Itraconazole, or Fluconazole, or who cannot tolerate these drugs.
- Also indicated for prophylaxis of invasive fungal infections in:
- Patients receiving remission-induction chemotherapy for Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndromes (MDS) with expected prolonged neutropenia.
- Hematopoietic Stem Cell Transplant (HSCT) recipients undergoing high-dose immunosuppressive therapy for graft-versus-host disease.
👉 Refractoriness is defined as infection progression or no improvement after ≥7 days of effective antifungal therapy.
👉 Use only under the supervision of a registered physician.
Store below 25°C.
Keep out of reach of children.
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✔️ Dosage & Administration
Form: Tablet
Administration: Swallow whole with water, with or without food. Do not crush or chew.
Loading Dose (Day 1): 300 mg (3 tablets) twice daily.
Maintenance Dose (Day 2 onwards): 300 mg (3 tablets) once daily.
Duration: Based on disease severity, immunosuppression recovery, and clinical response.
Pediatrics (<13 years): Not recommended (safety not established).
Geriatrics: No dose adjustment required.
Hepatic Impairment: Use with caution; monitor liver function.
Renal Impairment:
Mild–moderate: No adjustment.
Severe: Monitor closely for fungal breakthrough.
✔️ Side Effects
Gastrointestinal: Diarrhea, nausea, vomiting
Systemic: Fever, headache, cough
Laboratory: Hypokalemia
✔️ Drug Interactions
CYP3A4 Inhibition: May increase plasma levels of drugs metabolized by CYP3A4 (e.g., Midazolam, Alprazolam, Triazolam).
Avoid co-administration with:
Rifamycins (Rifampicin, Rifabutin)
Anticonvulsants (Phenytoin, Carbamazepine, Phenobarbital, Primidone)
Efavirenz
Contraindicated with ergot alkaloids, certain QT-prolonging drugs (Cisapride, Pimozide, Quinidine, Terfenadine, Astemizole, Halofantrine), and statins (Simvastatin, Lovastatin, Atorvastatin).
Contraindications
Hypersensitivity to Posaconazole or other azoles.
Concomitant use with drugs that can cause serious QT prolongation or rhabdomyolysis (see above).
Pregnancy & Lactation
Pregnancy: Not recommended unless benefits outweigh risks.
Lactation: Discontinue breastfeeding during therapy.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
