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Posaconazole inhibits fungal cell membrane synthesis by blocking ergosterol formation. Specifically, it targets Lanosterol 14-α-demethylase, a cytochrome P450 enzyme responsible for converting lanosterol into ergosterol. This leads to the accumulation of sterol precursors and the depletion of ergosterol, weakening the fungal cell membrane and impairing its function.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Treatment of Fungal Infections (≥13 years):
- Invasive Aspergillosis: For patients who are refractory or intolerant to Amphotericin B or Itraconazole.
- Fusariosis: For patients refractory or intolerant to Amphotericin B.
- Chromoblastomycosis & Mycetoma: For patients refractory or intolerant to Itraconazole.
- Coccidioidomycosis: For patients refractory or intolerant to Amphotericin B, Itraconazole, or Fluconazole, or for patients unable to tolerate these treatments.
- Prophylaxis of Invasive Fungal Infections:
- Patients undergoing remission-induction chemotherapy for Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndromes (MDS) with anticipated prolonged neutropenia and high risk of invasive fungal infections.
- Hematopoietic Stem Cell Transplant (HSCT) recipients receiving high-dose immunosuppressive therapy for graft-versus-host disease at high risk of fungal infections.
Note: Refractoriness is defined as infection progression or lack of improvement after at least 7 days of prior effective antifungal therapy.
Use only under a registered physician’s guidance.
Safety Advices
Alcohol
UNSAFE
The interaction of Posaconazole with alcohol is unknown. If you have any concerns about this, please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Posaconazole should not be used during pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Posaconazole.
Breastfeeding
CONSULT YOUR DOCTOR
There is currently no substantial research on the use of Posaconazole in breastfeeding/nursing mothers. Inform your doctor if you are a nursing mother before taking Posaconazole; your doctor will decide whether breastfeeding mothers can take Posaconazole.
Driving
CAUTION
It is unknown whether Posaconazole alters the ability to drive. Therefore, do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Inform your doctor before taking the Posaconazole if you have a kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.
SAFE IF PRESCRIBED
Inform your doctor before taking Posaconazole if you have a history of liver impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration | Posanox 100
Route: Oral (tablet) with or without food.
Tablet instructions: Swallow whole with water; do not crush, chew, or break.
Loading Dose:
300 mg (3 tablets) twice on the first day.
Maintenance Dose:
300 mg (3 tablets) once daily from the second day onward.
Duration:
Determined by the severity of infection, recovery from immunosuppression, and clinical response.
Administer strictly under physician guidance.
Pediatric (<13 years): Safety and efficacy not established; not recommended.
Geriatric: No dose adjustment needed.
Hepatic Impairment: Use cautiously; plasma levels may be higher. Monitor liver function before and during therapy.
Renal Impairment:
Mild to moderate: No dose adjustment needed.
Severe: Monitor closely for breakthrough infections.
✔️ Side Effects | Posanox 100
Common:
Diarrhea, nausea, vomiting, headache, fever, coughing, hypokalemia.
Pregnancy & Lactation:
Use only if the benefit outweighs risk; breastfeeding should be stopped when treatment begins.
✔️ Interaction
Posaconazole is a CYP3A4 inhibitor; caution is required when co-administered with drugs metabolized by CYP3A4 (e.g., Midazolam, Triazolam, Alprazolam).
Posaconazole plasma levels may decrease with Rifamycin antibiotics (Rifampicin, Rifabutin) or certain anticonvulsants (Phenytoin, Carbamazepine, Phenobarbital, Primidone, Efavirenz).
✔️ Contraindications
- Known hypersensitivity to posaconazole or other azole antifungals.
- Co-administration with:
- Ergot alkaloids
- CYP3A4 substrates like Terfenadine, Astemizole, Cisapride, Pimozide, Halofantrine, Quinidine
- HMG-CoA reductase inhibitors: Simvastatin, Lovastatin, Atorvastatin
- These combinations may increase drug concentrations, causing QTc prolongation and rare torsades de pointes.
✔️ Storage:
Store below 25°C.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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