Fluconazole is a triazole antifungal that inhibits fungal cytochrome P-450 enzymes, preventing the synthesis of ergosterol, a critical component of the fungal cell membrane. This disruption stops fungal growth and replication.
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Fungata is used for the treatment and prevention of a wide range of fungal infections, including:
Vaginal, oropharyngeal, and esophageal candidiasis
Superficial fungal infections such as tinea corporis, cruris, pedis, kerion, pityriasis versicolor, and onychomycosis
Systemic infections like invasive candidiasis, cryptococcal infections (including meningitis), and disseminated candidiasis
Prophylaxis of fungal infections in immunocompromised patients, including those undergoing chemotherapy or with neutropenia
Fungal urinary tract infections, coccidioidomycosis, histoplasmosis, and other serious systemic fungal infections
Superficial infections: 1–2 mg/kg daily
Systemic infections: 3–6 mg/kg daily (up to 12 mg/kg for severe infections, max 400 mg/day)
Administration Notes
Fungata can be given orally or intravenously.
Avoid co-administration with antacids, iron supplements, or any solution containing multivalent cations.
Drink adequate fluids during therapy to prevent concentrated urine.
Common: Nausea, abdominal discomfort, diarrhea, flatulence
Rare: Rash, anaphylaxis, hepatic abnormalities, exfoliative skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)
Special caution is required in patients with serious underlying conditions such as AIDS or cancer
Hypersensitivity to fluconazole or other triazole antifungals.
Not recommended during pregnancy or for women of childbearing potential unless necessary
Avoid breastfeeding during therapy as fluconazole passes into milk
Monitor liver function in patients with underlying hepatic, renal, or hematological conditions
Discontinue therapy if severe skin reactions occur
Use with caution in elderly or renal-impaired patients; adjust dosing as needed
Store in a cool, dry place away from light and heat. Keep out of reach of children.
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