Azonox 200 Tablet 1 Strip Price in Bangladesh

✔️ Pharmacology

Itraconazole works by inhibiting fungal cytochrome P450 enzymes, blocking the synthesis of ergosterol, a critical component of fungal cell membranes. This disrupts membrane integrity, inhibiting growth and causing fungal cell death.

💡 SUBA Technology: Azonox utilizes SUBA (Super Bio-Available) delivery to significantly improve absorption and efficacy of itraconazole, ensuring reliable plasma concentrations for optimal antifungal activity.

✔️ Side Effects

Nausea, indigestion, abdominal pain, headache, dizziness, constipation
Occasional:

Elevated liver enzymes, menstrual irregularities, and allergic skin reactions
Rare:

Hepatitis, cholestatic jaundice, Stevens-Johnson syndrome, peripheral neuropathy, hypokalemia, hair loss, edema

✔️ Dosage & Administration | 100 mg / 200 mg Formulations:

Superficial Infections

Vulvovaginal candidiasis: 200 mg twice daily for 1 day

Pityriasis versicolor: 200 mg once daily for 7 days

Tinea corporis/cruris: 100 mg daily for 15 days or 200 mg daily for 7 days

Tinea pedis/manuum: 100 mg daily for 30 days

Oropharyngeal candidiasis: 100 mg daily for 15 days (200 mg for AIDS/neutropenia)

Onychomycosis:

Continuous: 200 mg daily for 3 months

Pulse: 200 mg twice daily for 7 days; repeat after 21 days (2–3 courses)

Systemic Infections

Aspergillosis: 200 mg daily for 2–5 months (increase to twice daily for invasive disease)

Candidiasis: 100–200 mg daily for 3 weeks–7 months

Cryptococcosis (non-CNS): 200 mg daily for 10 weeks

Cryptococcal meningitis: 200 mg twice daily for 2–6 months

Histoplasmosis: 200 mg once/twice daily for up to 8 months

AIDS maintenance or neutropenia prophylaxis: 200 mg daily

✔️ Pediatric Use

Safety and efficacy in children have not been established.

✔️ Contraindications

Known hypersensitivity to itraconazole

Severe hepatic impairment

Concurrent use with rifampin, terfenadine, astemizole, cisapride, simvastatin, oral midazolam, triazolam, and similar agents

✔️ Pregnancy & Lactation

Contraindicated during pregnancy

Not recommended during breastfeeding

✔️ Drug Interactions

Significant interactions with:

Rifampin, phenytoin, phenobarbital

Digoxin, calcium channel blockers

Simvastatin, midazolam, terfenadine, cisapride

Avoid or closely monitor these combinations

✔️ Precautions & Warnings

Take with a full meal to enhance absorption

Avoid co-administration with antacids or H2 blockers; if necessary, separate by at least 2 hours

Monitor liver function during prolonged therapy (≥1 month)

Caution in cardiac or hepatic dysfunction

✔️ Storage

Store at below 25°C in a cool, dry place

Keep away from light and out of children's reach