HCG Injection 2500 IU

✔️ Side Effects

Possible adverse effects include:

• Pain or rash at the injection site
• Generalized rash
• Fever
• Allergic reactions
• Ovarian hyperstimulation syndrome (OHSS) in women
• Breast tenderness
• Abdominal discomfort, nausea, or diarrhea
• Enlargement of the ovaries or ovarian cysts
• Fluid and sodium retention in men receiving high doses
• Increased androgen-related effects

Severe OHSS can cause significant ovarian enlargement, large ovarian cysts, abdominal fluid accumulation, and other serious complications requiring urgent medical attention.

✔️ How hCG Works

hCG has activity similar to luteinizing hormone (LH), which plays an important role in the development and maturation of reproductive cells and the production of sex hormones.

In women, hCG can act in place of the natural mid-cycle LH surge. It stimulates the final maturation of ovarian follicles and triggers ovulation. It can also provide LH-like support during the luteal phase.

In men, hCG stimulates the Leydig cells of the testes, increasing testosterone production and supporting reproductive function.

✔️ Pharmacokinetics

After injection, peak hCG blood levels are generally reached within approximately 6 hours. The hormone is primarily metabolized through the kidneys. Following intramuscular administration, its apparent elimination half-life is approximately 2 days. With recommended treatment schedules, significant accumulation is not generally expected.

✔️ Drug Interactions

No clinically significant drug interactions are well established. Nevertheless, inform your doctor about all medicines, supplements, and fertility treatments you are currently using.

✔️ Pediatric Use

In children, hCG can stimulate androgen production and may result in precocious puberty. Treatment should be discontinued if signs of premature sexual development appear.

✔️ Pregnancy & Lactation

hCG should not be used during pregnancy as a fertility treatment. It is also not recommended during breastfeeding because its use may not be appropriate for the nursing infant or lactating mother.

✔️ Geriatric Use

Clinical studies of injectable chorionic gonadotropin have included limited numbers of adults aged 65 years and above. Use in older patients should therefore be based on individual clinical assessment.

✔️ Contraindications

hCG is contraindicated in patients with known or suspected androgen-dependent tumors, including prostate cancer or male breast cancer. It should not be used in pregnancy or during breastfeeding unless specifically directed by an appropriate specialist according to the product's approved indication.

✔️ Precautions & Warnings

Women receiving gonadotropin treatment may have an increased chance of multiple pregnancy. During fertility treatment, ovarian response should be monitored using ultrasound and, where appropriate, estrogen measurements.

If excessive ovarian stimulation develops, further gonadotropin treatment may need to be stopped and hCG withheld because administering hCG at that stage can increase the risk of OHSS.

Extra caution and medical monitoring are required in patients with:

• Heart failure or cardiovascular disease
• Kidney impairment
• Hypertension
• Epilepsy
• Migraine
• Conditions that may worsen because of increased androgen levels

In boys treated for cryptorchidism, hCG may cause premature sexual development or early closure of the growth plates. Skeletal development should therefore be monitored during treatment.

✔️ Overdose

Urinary gonadotropin preparations have relatively low acute toxicity, and specific symptoms from acute injectable overdose have not been well established. If an excessive dose is administered, medical assessment and supportive management may be required.

✔️ Storage:

• Store at 2–8°C in a refrigerator and do not freeze, or
• Store below 25°C for a single period of no more than 3 months, according to the product's storage instructions.
• Protect from light and moisture.
• Keep out of reach of children.