Anfree 0.5mg+10mg Tablet 1 Strip

✔️ Pharmacology / How It Works

This combination contains two medicines that work through complementary mechanisms:

Flupentixol is a thioxanthene neuroleptic that, at the low doses used in this combination, has anxiolytic and antidepressant effects.

Melitracen is a tricyclic antidepressant with activating properties. It helps improve mood and may reduce depressive symptoms.

Together, the two components provide antidepressant, anxiolytic, and activating effects.

After oral administration, peak blood concentrations of both flupentixol and melitracen are reached at approximately 4 hours. The biological half-life is approximately 35 hours for flupentixol and 19 hours for melitracen. Co-administration does not appear to significantly alter the pharmacokinetic characteristics of either component.

✔️ Words of Advice:

• Take the medicine exactly according to your doctor's instructions.
• Avoid alcohol during treatment.
• Do not stop the medicine abruptly unless instructed by your doctor.
• Tell your doctor if you have liver disease, thyroid problems, significant heart disease, glaucoma, or urinary difficulties.
• Inform your doctor before undergoing surgery or anesthesia.
• Monitor for significant changes in mood or behavior and report suicidal thoughts immediately.
• Use caution with driving or activities requiring alertness until you know how the medicine affects you.
• Keep all medicines out of the reach of children.

✔️ Side Effects:

• Restlessness
• Insomnia
• Dizziness
• Drowsiness or changes in alertness
• Dry mouth or other anticholinergic effects

✔️ Dosage & Administration

Take this medicine exactly as prescribed by your doctor.

Adults

The usual dose is:

2 tablets daily, generally taken as one tablet in the morning and one around noon.

In more severe cases, the morning dose may be increased to 2 tablets, if specifically prescribed.

Elderly Patients

The usual recommended dose is:

1 tablet in the morning.

Maintenance Dose

The usual maintenance dose is:

1 tablet in the morning.

If significant insomnia or severe restlessness occurs during the acute phase, the doctor may consider additional short-term treatment with a suitable sedative.

Do not change the dose or stop treatment suddenly without consulting your doctor.

✔️ Possible overdose management includes:

• Prompt medical evaluation
• Gastric decontamination when clinically appropriate
• Activated charcoal when indicated
• Supportive treatment of respiratory and cardiovascular function
• Treatment of convulsions with appropriate medicines such as diazepam when required
• Management of extrapyramidal symptoms with an appropriate anticholinergic agent such as biperiden under medical supervision

✔️ Pregnancy & Lactation

Use during pregnancy and breastfeeding is generally not recommended unless specifically considered necessary by the treating physician.

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential benefits and risks with your doctor before taking this medicine.

✔️ Flupentixol + Melitracen should not be used in patients with:

• Immediate recovery phase following myocardial infarction
• Bundle-branch conduction abnormalities
• Untreated narrow-angle glaucoma
• Acute intoxication with alcohol, barbiturates, or opioids
• Use of an MAO inhibitor within the previous 2 weeks
• Marked excitability or overactivity, where the activating effects of the medicine could worsen these symptoms

✔️ Precautions & Warnings

Patients who have previously been treated with sedative tranquilizers should generally have those medicines withdrawn gradually, rather than stopped abruptly.

Use caution in patients with significant cardiovascular disease, glaucoma, liver problems, thyroid disorders, urinary difficulties, or other conditions that may be affected by antidepressant or anticholinergic medicines.

Because this medicine may affect alertness in some individuals, use caution when driving, operating machinery, or performing activities requiring concentration, particularly when starting treatment.

Contact your doctor promptly if you experience significant changes in mood, worsening depression, unusual behavioral changes, or suicidal thoughts.

Inform your doctor that you are taking this medicine before undergoing surgery or receiving anesthesia.

✔️ Storage Conditions

• Store at a temperature not exceeding 30°C.
• Keep in a dry place.
• Protect from light.
• Keep out of reach and sight of children.