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Dasacent 50mg Tablet 1 Strip
Dasacent (Dasatinib)
- Treatment of adult patients with:
- Newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.
- Chronic, accelerated, or myeloid/lymphoid blast phase Ph+ CML with resistance or intolerance to previous therapy, including Imatinib.
- Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to previous therapy.
- Treatment of pediatric patients (1 year and older) with Ph+ CML in the chronic phase and newly diagnosed Ph+ ALL in combination with chemotherapy.
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✅ Description:
- Dasatinib inhibits several kinases, including BCR-ABL, SRC family, c-KIT, EPHA2, and PDGFRβ. It helps overcome resistance to Imatinib in leukemic cells by targeting mutations and alternative signaling pathways.
- Absorption: Dasatinib reaches maximum plasma concentrations within 0.5–6 hours after oral administration.
- Distribution: Highly protein-bound (96%) with an apparent volume of distribution of 2505 L.
- Elimination: Half-life is 3-5 hours, and 85% of the dose is excreted in the feces.
- Metabolism: Primarily metabolized by CYP3A4, with the active metabolite accounting for 5% of exposure.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects: Dasacent 50
- Myelosuppression, bleeding, fluid retention, cardiovascular events, pulmonary hypertension, QT prolongation, severe dermatologic reactions, tumor lysis syndrome.
✔️ Dosage & Administration: Dasacent 50
- Adults:
- Chronic phase CML: 100 mg orally once daily.
- Accelerated phase CML, blast phase CML, or Ph+ ALL: 140 mg orally once daily.
- Do not crush, cut, or chew tablets.
- Pediatric Patients (1 year and older):
- Doses based on body weight, ranging from 40 mg (10-20 kg) to 100 mg (≥45 kg) once daily.
- Monitor growth and development in children.
✔️ Drug Interactions:
- CYP3A4 Inhibitors/Inducers: Avoid co-administration with strong CYP3A inhibitors or inducers. Adjust Dasacent dosage if necessary.
- Gastric Acid Reducing Agents: Can reduce Dasatinib concentrations. Avoid H2 antagonists and proton pump inhibitors; use antacids with caution.
✔️ Contraindications:
- Hypersensitivity to Dasatinib or any component of the formulation.
✔️ Pregnancy & Lactation:
- Dasatinib may harm the fetus. Avoid pregnancy during treatment and for 30 days after.
- Breastfeeding is not recommended during treatment and for 2 weeks after.
✔️ Precautions & Warnings:
- Myelosuppression: Monitor blood counts, especially in advanced phases.
- Bleeding Risks: Increased risk of hemorrhage, especially with anticoagulants or platelet inhibitors.
- Fluid Retention: Manage fluid retention with diuretics or steroids if necessary.
- Cardiovascular Issues & PAH: Monitor for cardiac dysfunction and signs of pulmonary arterial hypertension.
- QT Prolongation & Dermatologic Reactions: Monitor for prolonged QT and severe skin reactions.
- Tumor Lysis Syndrome: Ensure proper hydration and electrolyte balance, particularly in high tumor burden cases.
✔️ Storage Conditions:
- Store below 30°C in a dry place, protected from light. Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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