Biofol 15mg Tablet | 10pcs Strip | 30pcs Box | Online Order | ePharma
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Biofol 15mg Tablet

Generic: Calcium Folinate BP

Type: Tablet

Pack Size: 10 Pcs

Biofol 15mg Tablet neutralizes the harmful effects of cancer medicine methotrexate. It contains calcium folinate, protecting healthy cells from methotrexate toxicity.

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Discount Price: ৳ 235
MRP: ৳ 250 6% Off

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Biofol 15mg Tablet 10's is a detoxifying agent and folic acid analog used in cancer treatment as an antidote to reduce the toxic effects of certain cancer drugs like methotrexate. It can also be used in combination with 5-fluorouracil for cytotoxic therapy in cancer treatment.

The tablet contains calcium folinate (Leucovorin), an active form of vitamin B, which protects healthy cells from the toxic effects of methotrexate while allowing it to target and kill cancer cells. It should be taken as soon as possible after using methotrexate.

Take Biofol 15mg Tablet 10's as directed by a healthcare professional. Common side effects may include nausea, diarrhea, rash, vomiting, itching, urticaria or hives, and stomatitis (oral mucositis). Most of these side effects do not require medical attention and will resolve over time. If they persist, consult your doctor.

Before using Biofol 15mg Tablet 10's, inform your doctor if you are allergic to any of its ingredients. Discuss your medical history and current medications with your doctor to avoid any potential negative effects. Inform your doctor if you are pregnant, planning pregnancy, breastfeeding, or if you have pernicious anemia, other forms of megaloblastic anemia due to vitamin B12 deficiency, GI toxicity, renal impairment, or a history of seizures.

Safety Advices


Avoid consuming alcohol as it may cause side effects and reduce the effectiveness of Biofol 15mg Tablet 10's.


Biofol 15mg Tablet 10's should not be used during pregnancy unless clearly necessary. Inform your doctor if you are pregnant or suspect pregnancy, and your doctor will assess the benefits and potential risks before prescribing the medication.


Biofol 15mg Tablet 10's should not be used by nursing mothers unless clearly necessary. Inform your doctor if you are breastfeeding, and your doctor will assess the benefits and potential risks before prescribing the medication.


Biofol 15mg Tablet 10's does not affect the ability to drive or operate machinery.


Inform your doctor if you have liver problems before taking Biofol 15mg Tablets. Your doctor may adjust the dosage based on your condition.


Inform your doctor if you have a pre-existing or a history of kidney condition before taking Biofol 15mg Tablet 10's. Your doctor may adjust the dosage based on your condition.

Similar Products

Uses of Biofol 15mg Tablet
  • Colorectal Cancer
  • Methotrexate toxicity
  • Megaloblastic anemia
How does Biofol 15mg Tablet work?

Biofol 15mg Tablet is a detoxifying agent and folic acid analog used in cytotoxic therapy to reduce the toxicity of certain cancer drugs, like methotrexate. It prevents healthy cells from the toxic effects of these medicines while allowing them to target and kill cancer cells. Additionally, it can be used in combination with 5-fluorouracil for cancer treatment.

Side Effects of Biofol 15mg Tablet
  • Nausea
  • Diarrhea
  • Rash
  • Vomiting
  • Itching
  • Urticaria or hives
  • Stomatitis (oral mucositis)
Quick Suggestions:
  • Regularly see a therapist to take care of your mental health during the cancer journey.
  • These practices can be effective in maintaining a healthy attitude and body.
  • Eat lean meats, healthy fats, fruits, vegetables, and whole-grain foods to boost energy levels.
  • Drink plenty of water to prevent dehydration, which is often observed in cancer patients.
  • Spend time doing light physical activities like strolling in the garden. Avoid over-exertion if feeling fatigued.
  • Do not consume alcohol with Biofol 15mg Tablet 10's to avoid potential interactions. Additionally, avoid tobacco use.
  • Take Biofol 15mg Tablet 10's 24 hours after taking methotrexate, as taking them simultaneously may counteract the effect of methotrexate. Inform your doctor if you are taking medications like phenytoin for seizures, as Biofol 15mg Tablet may counteract its antiepileptic effects.
Indication of Biofol 15mg Tablet

Calcium Folinate is shown in: 

  • To lessen the negative effects and balance the effects of the methotrexate withdrawal syndrome
  • To address the nutritional insufficiency that causes Megaloblastic frailty, such as sprue, folate deficiency
  • To address megaloblastic fragility during pregnancy and infancy

Tetrahydrofolic corrosive's 5-formyl subordinate, folic corrosive, may exist. It quickly converts to other inferior folic acid subordinates (such as tetrahydrofolate), hence its vitamin transport is equivalent to that of folic acid. The ability of this vitamin to function as a vitamin is unaffected by medications that inhibit dihydrofolate reductase, such as methotrexate, because it does not require this enzyme's activity for its transformation. This is typically how folic corrosive protection therapy is shown. However, it was shown in the 1980s that folacin corrosive can actually restart dihydrofolate reductase when methotrexate is present. Although the exact mechanism is unclear, it is believed that the polyglutamylation of methotrexate and dihydrofolate in threatening cells plays a significant role.

Folic acid, therefore, allows for some purine/pyrimidine blend to happen in the vicinity of dihydrofolate reductase hindrance, allowing for some common DNA replication forms to continue. Folic acid, in particular, causes dihydrofolate reductase to be specifically reactivated by folinic acid in typical cells.

Dosage & Administration of Biofol 15mg Tablet


  • Diminishing harmful effects of folic acid antagonists such as Methotrexate, Trimethoprim, etc. The usual dosage is one 15 mg tablet every 6 hours for 2 to 3 days.
  • Treatment of Megaloblastic anemia: The dosage is one 15 mg tablet daily.

Take Biofol 15mg Tablet as prescribed by your physician. Swallow the medicine with a glass of water and do not crush or chew it. The appropriate dose and duration will be determined by your doctor based on your age, body weight, and medical condition.


Biofol 15mg Tablet 10's may interact with anticancer medicines (e.g. fluorouracil, capecitabine, pafolacianine) and antibiotics (e.g. trimethoprim, ceftriaxone).

No drug-food interactions have been found with Biofol 15mg Tablet 10's.

Biofol 15mg Tablet 10's may also interact with certain disease conditions, including anemia, GI toxicity, renal impairment, and seizures. It is important to inform your doctor about any existing medical conditions before taking the medication.


Calcium Folinate treatment is contraindicated in known extreme touchiness to Calcium Folinate, or to any components of the item definition. Vindictive frailty or other Megaloblastic frailty where Vitamin B12 is lacking

Pregnancy & Lactation

There are no satisfactory and well-controlled clinical studies conducted in pregnant or breastfeeding women. It is not known whether this drug is excreted in human breast milk. Since many drugs are excreted in human breast milk, caution should be exercised when Calcium Folinate is administered to a nursing mother. It's important for pregnant or breastfeeding women to consult their healthcare provider before using this medication to assess the potential risks and benefits.

Precautions & Warnings

Before taking Biofol 15mg Tablet 10's, inform your doctor if you are allergic to any of its ingredients.

  • Calcium Folinate treatment may mask malignant anemia and other megaloblastic anemia resulting from vitamin B12 deficiency.
  • Calcium Folinate should only be used with 5-fluorouracil or Methotrexate under the direct supervision of an experienced clinician in the use of cancer chemotherapeutic agents.
  • Macrocytosis caused by certain cytotoxic therapeutic products (hydroxycarbamide, cytarabine, mercaptopurine, thioguanine) should not be treated with folinic acid.
  • In epileptic patients treated with Phenobarbital, Phenytoin, Primidone, and Succinimides, there is a chance of increasing the frequency of seizures due to a decrease in plasma concentrations of anti-epileptic drugs.
Storage Conditions

Don't store over 30°C. Keep absent from light and out of the reach of children.

Frequently Asked Questions (FAQ)


Biofol 15mg Tablet is generally not recommended for use in patients with pernicious anaemia or other megaloblastic anaemia caused by vitamin B12 deficiency.

Biofol 15mg Tablet is given alongside chemotherapy medications like fluorouracil (5-FU) to enhance its effects and improve its efficacy.

Biofol 15mg Tablet may cause serious side effects like facial swelling, sudden wheezing, breathing difficulty, and widespread rash or itching. If any of these symptoms occur, stop taking the medication and seek immediate medical attention.

Biofol 15mg Tablet starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

The effect of Biofol 15mg Tablet lasts for an average duration of 3 to 6 hours.

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Check our pricing section for Biofol 15mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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