Biofol 5mg Tablet | Uses, Dosage, Interaction, Contraindication | ePharma
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Biofol 5mg Tablet

Generic: Calcium Folinate BP

Type: Tablet

Pack Size: 10 Pcs

Biofol 5 Tablet is a detoxifying agent or folic acid analog that is used in cancer therapy as an antidote to decrease the toxic effects of certain cancer medications, such as methotrexate. It can also be used in cancer therapy in conjunction with 5-fluorouracil. (cytotoxic therapy).

Calcium folinate, also known as Leucovorin, is a type of vitamin B found in Biofol 5 Tablet. It is the active component of folic acid. The mechanism of action of Biofol 5 Tablet is to protect healthy cells from the toxic effects of methotrexate (cancer medications) while allowing it to penetrate and destroy cancer cells. It should be given as quickly as feasible after receiving methotrexate.

Use Biofol 5 Tablet as directed by a healthcare practitioner.

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Discount Price: ৳ 84.6
MRP: ৳ 90 6% Off

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Calcium Folinate is shown in: 

  • To lessen the negative effects and balance the effects of the methotrexate withdrawal syndrome
  • To address the nutritional insufficiency that causes Megaloblastic frailty, such as sprue, folate deficiency
  • To address megaloblastic fragility during pregnancy and infancy

Safety Advices


Avoid the consumption of alcohol as it may cause some side effects and make the effect of Biofol 5 less effective.


Biofol 5 should not be used in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Biofol 5


Biofol 5 should not be used in nursing mothers unless clearly necessary. So, inform your doctor if you are breastfeeding. Your doctor will weigh the benefits and potential risks before prescribing Biofol 5


Biofol 5 does not affect your ability to drive or operate machinery.


If you have a pre-existing or a history of kidney condition, inform your doctor before taking Biofol 5 Your doctor may adjust the dose of this medicine based on your condition.


If you have liver problems, inform your doctor before taking Biofol 5. Your doctor may adjust the dose of this medicine based on your condition.

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Uses of Biofol 5 Tablet
  • Treats Folic acid deficiency
  • Treats megaloblastic Anemia
  • Prevention of harmful effects of Methotrexate
How Biofol 5 Tablet works:

Biofol 5 Tablet is an active form of folic acid. Biofol 5 Tablet increases folic acid levels in the body. As a result, it helps to treat and prevent the decrease in the levels of folic acid in the body.

Side Effects of Biofol 5 Tablet
  • Nausea
  • Diarrhoea
  • Rash
  • Vomiting
  • Itching
  • Fainting
  • Fever
  • Convulsions
  • Agitation and anxiety
  • Indigestion
  • Urticaria or hives
  • Stomatitis
  • Difficulty in breathing
  • Difficulty in swallowing
Quick Suggestions:
  • You've been given a Calcium Folinate Tablet to help you cope with the adverse effects of methotrexate.
  • It should be taken 24 hours after methotrexate. It may counteract the impact of methotrexate if consumed concurrently.
  • There may be a reaction if you take Biofol 5 Tablet 10 with booze.
  • Tobacco use should be avoided.
  • Inform your doctor if you are also taking medicines for seizures, such as phenytoin, as Calcium Folate Tablets may interfere with the antiepileptic benefits.
Indication of Biofol 5

Biofol 5 Tablet is a detoxifying agent or folic acid analog that is used in cytotoxic treatment as an antidote to decrease the toxicity and impact of certain cancer medications such as methotrexate. The mechanism of action of Biofol 5 is to protect healthy cells from the toxic effects of methotrexate (or other cancer medications) while allowing it to penetrate and destroy cancer cells. Aside from that, it can be used in cancer therapy in conjunction with the medication 5-fluorouracil. (cytotoxic therapy).


Tetrahydrofolic corrosive's 5-formyl subordinate, folic corrosive, may exist. It quickly converts to other inferior folic acid subordinates (such as tetrahydrofolate), hence its vitamin transport is equivalent to that of folic acid. The ability of this vitamin to function as a vitamin is unaffected by medications that inhibit dihydrofolate reductase, such as methotrexate, because it does not require this enzyme's activity for its transformation. This is typically how folic corrosive protection therapy is shown. However, it was shown in the 1980s that folacin corrosive can restart dihydrofolate reductase when methotrexate is present. Although the exact mechanism is unclear, it is believed that the polyglutamylation of methotrexate and dihydrofolate in threatening cells plays a significant role.

Folic acid, therefore, allows for some purine/pyrimidine blend to happen in the vicinity of dihydrofolate reductase hindrance, allowing for some common DNA replication forms to continue. Folic acid, in particular, causes dihydrofolate reductase to be specifically reactivated by folinic acid in typical cells.

Dosage & Administration of Biofol 5


  • Reduction of the negative effects of corrosive folate opponent. Trimethoprime, methotrexate, etc. Typically, the dosage is one 15 mg pill every 6 hours for two to three days.
  • Megaloblastic Iron Deficiency: One 15 mg tablet daily is the recommended dosage for treating megaloblastic iron deficiency.

When calcium folinate is used with a folic acid antagonist (e.g., cotrimoxazole, pyrimethamine), the folic acid antagonist's effectiveness may be decreased or neutralized altogether.

Calcium folinate may reduce the effect of anti-epileptic drugs such as phenobarbital, primidone, phenytoin, and succinimides, as well as increase the frequency of seizures (a decrease in plasma levels of enzymatic inductor anticonvulsant drugs may be observed due to increased hepatic metabolism, as folates are one of the cofactors) (see also sections 4.4 and 4.8). The effectiveness and toxicity of 5-fluorouracil have been demonstrated to improve when calcium folinate is given at the same time.


Due to vitamin B12 insufficiency, intrathecal and intraventricular administration, hypersensitivity, pernicious anemia, and other megaloblastic anemias might occur.

Pregnancy & Lactation

There are no satisfactory and well-controlled clinical thinks about conducted on pregnant or breastfeeding ladies. It isn't known whether this medication is excreted in a human drain. Since numerous drugs are excreted in the human brain, caution ought to be worked out when Calcium Folinate is managed by a nursing mother.

Precautions & Warnings
  • Treatment with Calcium Folate may mask megaloblastic iron deficit and other malignant fragility caused by vitamin B12 insufficiency.
  • When used with 5-fluorouracil or methotrexate, Calcium Folinate should be done so under the close supervision of a doctor who has experience using cancer chemotherapy drugs.
  • Numerous cytotoxic medications, such as circuitous or coordinated DNA union inhibitors, cause macrocytosis (hydroxycarbamide, cytarabine, mercaptopurine, thioguanine). Folic acid should not be used to treat this type of macrocytosis.
  • Due to a decrease in plasma concentrations of the anti-epileptic medicine, phenobarbital, phenytoin, primidone, and succinimides, there is a potential to prolong the recurrence of seizures in epileptic patients receiving these treatments.
Storage Conditions

Don't store over 30°C. Keep absent from light and out of the reach of children.

Frequently Asked Questions (FAQ)

Biofol 5 Tablet is an antidote to the side effects of various chemotherapy medications, such as methotrexate.

It is not recommended if you have a history of intolerance to any of the components in Biofol 5 Tablet, or if you have Pernicious anemia or other anemias caused by vitamin B12 insufficiency.

The time taken for Biofol 5 Tablet to start working may vary depending on the patient's medical condition and the dosage. It is important to take the medication as prescribed by the doctor.

Biofol 5 Tablet is contraindicated to use in populations with pernicious anaemia or other forms of megaloblastic anaemia caused by vitamin B12 deficiency.
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