Prostacin D Capsule 1 Strip

✔️ How does Prostacin D Capsule work?

This combination drug includes Tamsulosin Hydrochloride, an alpha1A-adrenoreceptor antagonist, and Dutasteride, a dual 5-alpha reductase inhibitor (5ARI). Together, they address both the dynamic and static components of BPH:

• Tamsulosin: Relaxes smooth muscles in the prostate and bladder neck by blocking alpha1A and alpha1D receptors, improving urine flow and reducing symptoms.
• Dutasteride: Inhibits the conversion of testosterone to dihydrotestosterone (DHT), reducing prostate size and addressing the underlying cause of BPH.

✔️ Side Effects of Prostacin D

Impotence, decreased libido, breast disorders (enlargement, tenderness), ejaculation disorders, and dizziness.

✔️ Dosage & Administration of Prostacin D

• Adults (including elderly): Take one capsule (Tamsulosin 0.4 mg + Dutasteride 0.5 mg) orally, 30 minutes after the same meal each day. Swallow the capsule whole; do not chew or open it.
• Renal impairment: No dosage adjustment is needed, but caution is advised for severe cases.
• Hepatic impairment: Use with caution in mild to moderate cases. Contraindicated in severe hepatic impairment.
  Always follow a registered physician's advice.

Take Prostacin D with or without food as directed by your physician. Swallow it as a whole with a glass of water. Do not crush, chew, or break it.

✔️ Interactions: Prostacin D

Dutasteride: CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase Dutasteride levels. No significant interactions with Tamsulosin or other drugs like warfarin or digoxin.

Tamsulosin: May enhance hypotensive effects when taken with blood pressure-lowering drugs, PDE5 inhibitors, or other alpha-blockers. Avoid combining with cimetidine or other alpha-blockers.

✔️ Do not use Prostacin D in:

• Women, children, and adolescents.
• Patients are allergic to Dutasteride, Tamsulosin, soya, peanut, or excipients.
• Those with a history of orthostatic hypotension or severe hepatic impairment.

✔️ Pregnancy & Lactation

• Contraindicated for women: Dutasteride may harm a male fetus if exposed during pregnancy. Men on this medication should use condoms if their partner is or could become pregnant.
• Fertility: Dutasteride may reduce sperm count and motility, potentially affecting male fertility.
• Lactation: It is unknown if Tamsulosin or Dutasteride passes into breast milk.

✔️ Precautions & Warnings

• Cardiac failure: A slightly higher risk has been observed with this combination. Monitor patients closely.
• Prostate cancer: Regular PSA testing and digital rectal exams are essential. PSA levels drop by about 50% after 6 months of treatment; establish a new baseline for monitoring.
• Hypotension: Risk of orthostatic hypotension; advise patients to sit or lie down if they feel dizzy.
• Intraoperative Floppy Iris Syndrome (IFIS): May occur during cataract surgery. Discontinue Tamsulosin 1-2 weeks before surgery if possible.
• Breast cancer: Rare cases have been reported in men taking Dutasteride. Patients should report any breast changes, such as lumps or discharge.

✔️ Storage Conditions

Store in a cool, dry place, away from light.