Brodil 4mg Tablet | ePharma
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Brodil 4mg Tablet

Generic: Sulbutamol

Type: Tablet

Pack Size: 20S

Generic Name: Salbutamol 4mg 

Company name: ACI Limited


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Discount Price: ৳ 8.56
MRP: ৳ 9.2 7% Off

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✅ Description:

Indications

Brodil 4 belongs to a class of drugs known as fast-acting bronchodilators or "relievers." It is used to treat asthma and chronic obstructive pulmonary disease (COPD) symptoms such as coughing, wheezing, and shortness of breath. Brodil 4 can be taken with or without food. The dose will be determined by your condition and how you react to the medication. Take it at the same time every day if possible. It is critical that you continue to take this medication until your doctor instructs you otherwise.

Pharmacology

Salbutamol is a synthetic sympathomimetic agent with a high affinity for beta-2 adrenergic receptors. Salbutamol causes bronchodilation by stimulating beta-2-adrenergic receptors in bronchial smooth muscles, causing bronchial muscle fibers to relax. Spirometric measurements show an improvement in pulmonary function as a result of this action.

Dosage & Administration

Salbutamol tablet or syrup-
Children:

  • 2-6 years: 2.5 ml syrup, 3-4 times daily
  • 6-12 years: 5 ml syrup, 3-4 times daily
  • Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily)

Adults: 

  • 2-4 mg tablet, 3-4 times daily. The maximum single dose is 8 mg tablet.
     

Salbutamol Respirator Solution: 

To be used with a suitable nebulizer device under the direction of a physician. The solution must not be injected or ingested.

Method-1 (Intermittent Administration):

  • Adults (and the elderly): 0.5 ml-1.0 ml salbutamol up to four times a day. Up to 40mg per day can be given under strict medical direction in the hospital. 0.5-1 ml solution should be diluted to a final volume of 2-4 ml with sterile normal saline solution. It will take time about 10 minutes.
  • Salbutamol respiratory solution may be used undiluted for intermittent administration. For this 2.0 ml of the solution is placed in the nebulizer and the patient is allowed to inhale until bronchodilation is achieved. This usually takes 3-5 minutes.
  • Children under 12 years of age: 0.5 ml of the solution diluted to 2.0-4.0 ml with normal saline. Some children may however require higher doses of up to 1.0 ml of the solution. Intermittent treatment may be repeated four times a day.

Method-2 (Continuous administration): 

  • 1-2 ml solution is diluted to make up to 100 ml with normal saline solution. The diluted solution is administered by a suitable nebulizer device. When there is a risk of anoxia through hypoventilation, oxygen should be added to the inspired air.
     

Salbutamol nebulizer solution: To be used with a suitable nebulizer device under the direction of a physician. The solution must not be injected or ingested.

Adults & Elderly: 

  • 2.5 mg to 5 mg Salbutamol up to 4 times a day. Up to 40 mg/day may be given under strict medical direction in the hospital.

Children under 12 years:

  • 2.5 mg up to 4 times a day. A higher dose of up to 5 mg four times a day may be used if required.

Salbutamol injection:
Adults:

  • Salbutamol I.V. infusion solution is used to prepare a solution for continuous intravenous infusion. It should not be injected undiluted. A suitable solution for infusion may be prepared by diluting 5 mL of Salbutamol I.V. infusion solution (1000 mcg/mL) in 500 mL of a chosen i.v. the solution to provide a salbutamol concentration of 10 mcg/mL.
  • The only recommended diluents are Sodium Chloride Injection, or Sodium Chloride and Dextrose Injection.
  • Infusion rates providing 3 to 20 micrograms of salbutamol/minute (0.3 to 2ml/minute of the above infusion solution) are usually adequate. Infusion rates can be started at 5 mcg of salbutamol/min., and can be increased to 10 mcg/min., and 20 mcg/min. at 15 - 30 minute intervals, if necessary.
  • As with all parenteral drug products, intravenous admixtures should be inspected visually for clarity, particulate matter, precipitate, discoloration, and leakage prior to administration.
  • All unused admixtures of Salbutamol infusion solution with infusion fluids should be discarded 24 hours after preparation.

Children and Adolescents (<18 years of age): 

  • The dosage of Salbutamol infusion solution in the pediatric age group has not been established. At present, there are insufficient data to recommend a dosage regimen for children.

Salbutamol Inhalation Capsule:

Adults:

  • One or two inhalation capsules may be administered as a single dose to relieve bronchospasm and manage intermittent episodes of asthma. For adults, the usual recommended dosage of Salbutamol inhalation capsule for inhalation is the contents of one 200 microgram capsule every 4 to 6 hours using a device. Some patients may require the contents of two 200 microgram capsules inhaled every 4 to 6 hours. Large doses or frequent administration are not advised. To control recurring/intermittent episodes of bronchospasm, the use of salbutamol powder for inhalation can be continued as medically indicated.

Children: 

One Salbutamol inhalation capsule is the recommended dose for children 4 years of age and older for relief of acute bronchospasm in the maintenance of episodic asthma or before exercise. For routine maintenance or prophylactic therapy, one inhalation should be administered three or four times per day. If necessary, this dosage can be increased to the inhalation of two inhalation capsules. The bronchodilator effect of each inhaled Salbutamol inhalation capsule administration lasts at least four hours. Such patients should be advised not to increase the dose of their inhalers and to seek medical attention immediately.

Excercise-induced Asthma:

  • Adults: 400 micrograms
  • Child: 200 micrograms, 15-30 minutes prior to any physical exertion.

Interaction

Tell your doctor about all of your drugs, including beta-blockers (e.g., propranolol, timolol), all asthma medications, ephedrine, epinephrine, pseudoephedrine, antidepressants, MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine), diuretics, and anti depress (e.g., hydrochlorothiazide). All over-the-counter drugs, especially those used for colds, allergies, asthma, or dieting, should be read carefully because they may include the substances listed above. Do not begin or stop taking any medication without first consulting your doctor or pharmacist.

Contraindications

Salbutamol is contraindicated in patients with a history of hypersensitivity to Salbutamol or any of its components.

Side Effects

Salbutamol may cause fine tremors of skeletal muscles (particularly the hands), palpitations, and muscle cramps. Tachycardia, tenseness, headaches, and peripheral vasodilatation have been reported after large doses.

Pregnancy & Lactation

Pregnancy: The drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: It is not known whether this drug is excreted in human milk. Because of the potential of the tumorigenicity shown for Salbutamol in some animal studies, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Precautions & Warnings

Salbutamol should be used with caution in patients with hyperthyroidism, cardiovascular disease, occlusive vascular disorders, hypertension, and aneurysms. Hypokalaemia associated with high doses of Salbutamol may result in increased susceptibility to digitalis-induced cardiac arrhythmia. Tachyphylaxis with resistance may occur with prolonged use of high dosage. Care is necessary when treating patients with diabetes mellitus or closed-angle glaucoma and in those receiving antihypertensive therapy

Storage Conditions

Should be stored in a cool and dry place.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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