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Reucent XR 15mg Tablet 1 Strip
Upadacitinib is a JAK inhibitor that works by interfering with the intracellular signaling of cytokines and growth factors, which are involved in immune system processes and the development of rheumatoid arthritis. It prevents the activation of signal transducers and activators of transcription (STATs), which are responsible for gene expression in immune cells.
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✅ Description:
- Reucent XR is used for treating adults with moderate to severely active rheumatoid arthritis, particularly when there has been an inadequate response or intolerance to methotrexate.
✔️ Side Effects:
Common side effects include:
- Upper respiratory tract infections.
- Nausea.
- Cough.
- Fever (pyrexia).
✔️ Dosage and Administration:
- The recommended dose is 15 mg once daily.
- It can be taken either monotherapy or in combination with methotrexate or other non-biologic disease-modifying antirheumatic drugs (DMARDs).
- Avoid initiation or interruption if:
- Absolute lymphocyte count is below 500 cells/mm³.
- Absolute neutrophil count is below 1000 cells/mm³.
- Hemoglobin level is below 8 g/dL.
- Pediatric Use: Safety and efficacy in children (aged 0-18 years) have not been established.
- Hepatic Impairment: Not recommended for patients with severe hepatic impairment.
✔️ Overdose Effects:
- In clinical trials, doses up to 60 mg extended-release daily showed adverse events similar to lower doses.
- Overdose: Monitor for signs of adverse reactions and treat appropriately. Reucent XR is largely eliminated within 24 hours of dosing.
✔️ Interactions:
- Strong CYP3A4 Inhibitors (e.g., ketoconazole) increase Reucent XR exposure. Use with caution in patients receiving chronic treatment with such inhibitors.
- Strong CYP3A4 Inducers (e.g., rifampin) decrease Reucent XR exposure, potentially reducing its therapeutic effect. Avoid co-administration with strong CYP3A4 inducers.
✔️ Pregnancy & Lactation:
- Pregnancy: Limited data are available on human use during pregnancy, but based on animal studies, Reucent XR may adversely affect a developing fetus.
- Breastfeeding: It is advised not to breastfeed while using Reucent XR.
✔️ Precautions & Warnings:
- Serious Infections: Avoid use in patients with active, serious infections.
- Malignancy: Carefully consider the risks and benefits before starting treatment in patients with a known malignancy.
- Thrombosis: Evaluate the risks of treatment in patients at higher risk of blood clot formation.
- Gastrointestinal Perforations: Use with caution in patients who are at increased risk.
- Laboratory Monitoring: Monitor lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids.
- Embryo-Fetal Toxicity: Advise females of reproductive potential about the potential risk to a fetus and to use effective contraception during treatment.
- Vaccinations: Avoid use with live vaccines.
✔️ Storage Conditions:
- Store below 25°C.
- Keep away from light and out of reach of children.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
