Larsulin Injection 100IU/ml-3ml Vial

✔️ Uses of Larsulin Injection 100IU/3ml

• Treats Diabetes Mellitus

✔️ How does Larsulin Injection 100IU/3ml work?

Larsulin Injection 100IU/ml will be given to you only by a doctor or a nurse under the skin (subcutaneously, usually thighs, upper arm, or abdomen. Your doctor will decide the right dose and duration depending on your age, body weight, and disease condition.

✔️ Side Effects Larsulin Injection 100IU/3ml work?

Side effects of Insulin glargine are hypoglycemia, allergic reactions, injection site reaction, lipodystrophy, pruritus, and rash.

✔️ Quick Suggestions:

• Insulin Glargine is injected under the skin. It needs to be injected once daily, at the same time every day.
• Injection below the skin of the abdomen results in faster absorption than other injection sites.
• Injection sites must be rotated to prevent hard lumps from developing at one site.
• Exercise regularly, eat a healthy diet, and take your other diabetes medicines (if prescribed) alongside.
• Hypoglycemia (low blood sugar level) is a common side effect. Hence, regular monitoring of blood sugar levels is required while taking this medicine.
• Always carry some high-sugar food such as sugar candy or glucose candy, fruit juice, and glucose with you so that you can take it when you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremors, weakness, and anxiety.
• Opened vials/cartridges stay good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
• Do not use it if the preparation is no longer clear and colorless, or if it contains particles.

✔️ Indication of Larsulin Injection 100IU/3ml

• Larsulin Injection 100IU/ml: Contains Insulin glargine, categorized as an Antidiabetic medication.
• Purpose: Used for treating Diabetes mellitus.
• Diabetes mellitus: Occurs when the body lacks sufficient insulin to regulate blood sugar, causing elevated levels.
• Symptoms: Include excessive thirst, frequent urination, intense hunger, unexplained weight loss, fatigue, irritability, blurred vision, slow-healing sores, frequent infections, and elevated ketone levels in urine.

✔️ Pharmacology

Insulin Glargine is a sterile solution containing insulin glargine, designed for subcutaneous injection. It's a recombinant human insulin analog, known for its long-acting effects (up to 24 hours). Produced using recombinant DNA technology, insulin glargine primarily regulates glucose metabolism. Its main action involves stimulating glucose absorption by peripheral tissues like skeletal muscle and fat, while also curbing hepatic glucose production. Furthermore, insulin glargine suppresses lipolysis and proteolysis and enhances protein synthesis. This helps lower blood sugar levels, contributing to diabetes management.

✔️ Dosage & Administration of Larsulin Injection 100IU/3ml

• Insulin Glargine offers consistent glucose-lowering over 24 hours, administered once daily.
• Individualize dosing based on clinical response, and monitor blood glucose.
• Type 1 diabetes: Initiate at approximately one-third of total daily insulin needs, with short-acting insulin for the remainder.
• Type 2 diabetes: Initiate at 10 units (or 0.2 units/kg) once daily, adjust as needed.
• When switching from other insulin, adjust shorter-acting insulins and oral anti-diabetic drugs.
• Injection time is flexible but should be consistent each day.
• Cartridge: Mix insulin by gently inverting the pen 8-10 times.
• Vial: Shake or rotate the vial gently, prepare the syringe, inject air into the vial, withdraw the dose, and remove air bubbles if present.
• Choose injection sites with loose skin, and alternate sites to prevent damage.
• Cleanse skin with alcohol, insert needle at a 45° angle, inject insulin, and apply gentle pressure.
• In case of overdose symptoms (hypoglycemia), test blood glucose, consume glucose, and seek medical attention.
• For a missed dose, take it as soon as remembered. Skip if close to the next dose. Avoid double dosing.

✔️ Interaction

Larsulin Injection 100IU/ml can interact with various medications and conditions:

Drug-Drug Interactions:

• Interaction with other antidiabetic pills (sitagliptin)
• Interaction with blood sugar enhancers (diazoxide)
• Interaction with blood pressure-lowering pills (metoprolol, clonidine)
• Interaction with antidepressants (lithium, fluoxetine)
• Interaction with painkillers (aspirin, pentoxifylline, propoxyphene)
• Interaction with anti-TB drug (isoniazid)
• Interaction with growth hormone (somatropin)
• Interaction with thyroid hormone-related drugs (levothyroxine)
• Interaction with antipsychotic medicines (phenothiazine, clozapine, olanzapine)
• Interaction with anti-cholesterol drugs (fenofibrate)
• Interaction with anti-asthmatic drugs (epinephrine, salbutamol, terbutaline)
• Interaction with female hormones like oestrogens and progestogens

Drug-Food Interactions:

• Interaction with ayurvedic, homoeopathy, Unani, herbal supplements or OTC items
• Interaction with alcoholic beverages (may raise or lower blood sugar levels)

Drug-Disease Interactions:

• Should not be given to patients with kidney disease
• Should not be given to patients with liver disease
• Should not be given to patients with low blood sugar/glucose level (hypoglycaemia)
• Should not be given to patients with low potassium levels (hypokalaemia)

Always inform your doctor about all the medications you're taking and any medical conditions you have before starting INSULIN GLARGINE to ensure its safe and effective use.

✔️ Contraindications

Insulin Glargine is contraindicated in patients with hypersensitivity to Insulin Glargine or any of its excipients.

✔️ Pregnancy & Lactation

Pregnancy Category C is assigned to Insulin Glargine, indicating that its use during pregnancy should be carefully considered, weighing potential benefits against potential risks to the fetus. Breastfeeding mothers should also exercise caution, as it's unclear if insulin glargine is excreted in breast milk. Since various drugs, including human insulin, are found in breast milk, nursing women should take precautions when using insulin glargine. Adjustments to insulin dosage and diet may be necessary for breastfeeding women. Always consult your healthcare provider before making any decisions regarding medication use during pregnancy or while breastfeeding.

✔️ Precautions & Warnings

• Renal or Hepatic Impairment: Individuals with renal (kidney) or hepatic (liver) impairment should be cautious when using Insulin Glargine.
• Pregnancy: Pregnant individuals should carefully weigh the potential benefits and risks of using Insulin Glargine, as the decision to use it during pregnancy should be made in consultation with a healthcare provider.
• Lactation: While using Insulin Glargine during breastfeeding is considered safe, nursing mothers should consult their healthcare provider for guidance and possible adjustments.
• Children Under 6 Years: Insulin Glargine is not recommended for children below 6 years of age.
• Transferring from Other Insulin: When switching from other insulin treatments to Insulin Glargine, monitoring of blood glucose levels and other relevant parameters is important.
• Monitoring: Regular monitoring of serum glucose, potassium, electrolytes, HbA1c (glycated hemoglobin), and lipid profile is recommended for individuals using Insulin Glargine.
• Concomitant Illness and Infections: Individuals with concomitant illnesses, especially infections, should exercise caution while using Insulin Glargine.
• Hypokalemia: Monitoring for hypokalemia (low potassium levels) is important, as Insulin Glargine may potentially lead to decreased potassium levels.

✔️ Storage Conditions

• Store between 2°C to 8°C in the refrigerator
• Do not freeze it
• Keep it out of the reach of children
• Do not open the carton of vials to protect it from light
• Any unused portion should not be stored and should be appropriately discarded.