Pregan ER 82.5mg Tablet

✔️ Side Effects

• Dizziness
• Sleepiness or drowsiness
• Blurred or double vision
• Difficulty concentrating
• Dry mouth
• Fatigue
• Peripheral or generalized swelling (edema)
• Weight gain
• Tremor
• Loss of balance or coordination
• Constipation
• Nausea or vomiting
• Confusion or disorientation

✔️ How Pregan ER 82.5 Works

Pregabalin is structurally related to the neurotransmitter GABA and binds to the alpha-2-delta subunit of voltage-gated calcium channels in the nervous system.

This reduces the release of several excitatory neurotransmitters and helps decrease abnormal nerve activity. As a result, it can reduce nerve pain and abnormal electrical activity associated with seizures.

✔️ Dosage and Administration

The dose and duration depend on the condition being treated and how the patient responds.

Pregan ER should be taken exactly as prescribed by the doctor.

• It may be taken with or without food.
• Take it at approximately the same time each day.
• Swallow the extended-release tablet whole.
• Do not crush, chew, or break the tablet.
• Your doctor may start treatment at a lower dose and gradually adjust it.

Because the exact dose for an extended-release formulation can differ from immediate-release pregabalin, follow the specific dose prescribed for Pregan ER 82.5 rather than changing the dose yourself.

✔️ Drug Interaction

Pregabalin has relatively few metabolic drug interactions, but it can have additive effects on the central nervous system with other medicines.

• Lorazepam: May increase sedative effects.
• Opioids: May increase drowsiness and respiratory depression.
• Benzodiazepines: May cause increased CNS depression.
• ACE inhibitors: May increase the risk of angioedema.
• Thiazolidinediones: May increase the risk of weight gain and peripheral edema.
• Alcohol: Can significantly increase dizziness and drowsiness and should generally be avoided.

✔️ Contraindications

Pregan ER should not be used in patients with a known hypersensitivity or allergy to pregabalin or any component of the formulation.

Extra caution and dose adjustment may be necessary in patients with:

• Kidney impairment
• A history of angioedema
• Significant cardiovascular disease
• Conditions associated with fluid retention

✔️ Missed Dose & Overdose

If You Miss a Dose

Take the missed dose when you remember, unless it is nearly time for your next scheduled dose. If it is almost time for the next dose, skip the missed dose and continue with your normal schedule.

Do not take a double dose to compensate for a missed one.

Overdose

Pregabalin overdose may cause excessive sleepiness, dizziness, confusion, agitation, loss of consciousness, or other CNS effects. In severe cases, respiratory depression or coma may occur, particularly when combined with other CNS depressants.

Seek urgent medical attention if an overdose is suspected.

✔️ Pregnancy and Breastfeeding

Pregnant women, women planning pregnancy, and those who could become pregnant should discuss pregabalin treatment with their doctor.

There is insufficient information regarding the presence of pregabalin in human breast milk and its effects on breastfed infants. Breastfeeding is generally not recommended during treatment unless specifically advised by a healthcare professional.

✔️ Important Warnings

Pregabalin can cause dizziness, drowsiness, blurred vision, and impaired coordination. Avoid driving, operating machinery, or performing hazardous activities until you know how the medicine affects you.

Contact your doctor promptly if you develop:

• New or worsening depression
• Suicidal thoughts or behavior
• Significant changes in mood or behavior
• New vision problems
• Severe muscle pain or weakness
• Severe swelling of the face, lips, tongue, or throat

Angioedema

Pregabalin can rarely cause angioedema, which may involve swelling of the face, lips, tongue, throat, or airway.

If swelling of the tongue or throat, difficulty breathing, or other signs of a severe allergic reaction occur, stop the medicine and seek emergency medical care immediately.

The risk may be increased when pregabalin is combined with ACE inhibitors or certain mTOR inhibitors.

Stopping Pregan ER

Do not stop pregabalin suddenly. Abrupt or rapid discontinuation can cause withdrawal-like symptoms such as:

• Insomnia
• Nausea
• Headache
• Diarrhea
• Anxiety or other symptoms

It may also increase the risk of seizures in patients taking it for epilepsy. The medicine should generally be tapered gradually under medical supervision.

✔️ Storage:

• Store according to the manufacturer's recommended conditions.
• Keep in a cool, dry place.
• Protect from excessive heat and moisture.
• Keep out of reach of children.