Neugalin XR 165mg Capsule is a medication used to relieve pain caused by nerve damage (neuropathic pain) due to conditions like diabetes, shingles, spinal cord injury, and others. It is also used to treat muscle pain and stiffness in fibromyalgia and certain types of seizures in combination with other medicines.
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Pregabalin is utilized in the treatment of various conditions, including:
Regarding alcohol, there is no known interaction, but excessive alcohol consumption can damage nerves, so consultation with a doctor is advised.
Regarding pregnancy, limited safety information is available, and effective contraception is advised for women of childbearing age taking this medicine.
For breastfeeding, Pregabalin is passed into breast milk, and its effect on the baby is unknown, so the decision to continue breastfeeding or discontinue the medication depends on the doctor's assessment of benefits.
Regarding driving, Neugalin XR 165mg Capsule may have a minor or moderate influence, causing blurred vision, dizziness, and drowsiness. Caution or avoidance of driving is recommended if you don't feel well or are unable to be alert.
Neugalin XR 165mg Capsule should be used with caution in patients with kidney diseases (such as decreased urination). Therefore, consult your doctor before taking it.
Neugalin XR 165mg Capsule should be used with caution in patients with severe liver diseases. Therefore, consult your doctor before taking it.
Pregabalin acts by reducing the action of certain chemical substances in the brain. Thus, it impairs the transmission of pain signals from the brain and relieves pain.
Pregabalin is an anti-convulsant medication used for the prevention of neuropathic pain, epilepsy, fibromyalgia, and neuralgia. It works by calming damaged or overactive nerves and reducing the number of pain signals sent by damaged nerves. Potential side effects include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and abnormal thinking. Inform your doctor about symptoms of suicidal ideation, drug addiction, pulmonary issues, muscle pain, weakness, and kidney, liver, or heart diseases. Caution is advised for pregnant or breastfeeding women, and the safety of children under 18 years is not established.
Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It does not have a specific binding affinity for GABAA, GABAB, or benzodiazepine receptors. Instead, pregabalin exhibits high affinity to the alpha-2-delta subunit, which is an auxiliary subunit of voltage-gated calcium channels, particularly in tissues of the central nervous system.
The oral bioavailability of pregabalin is equal to or greater than 90%, and it is not significantly affected by dosage. The elimination of pregabalin from the systemic circulation primarily occurs through renal excretion in the form of an unchanged drug. The elimination half-life of pregabalin is approximately 6.3 hours in individuals with normal renal function.
Adult Dose:
Neuropathic pain, Postherpetic Neuralgia:
Diabetic Peripheral Neuropathic Pain:
Adjunct in partial seizures:
Fibromyalgia:
Child Dose: Safety and efficacy not established.
Renal Dose for Renal Impairment:
Hemodialysis:
CrCl (ml/min) Dosage Recommendation:
"Caution is advised when using Pregabalin with alcohol, as it may lead to severe drowsiness, dizziness, and impaired coordination. It is recommended to avoid alcohol consumption while taking Pregabalin to minimize the risk of side effects.
Additionally, Pregabalin may interact with various medications, including Lorazepam, Buprenorphine, Oxycodone, Propoxyphene, Azatadine, Pioglitazone, and Ramipril. It is essential to inform your doctor about all the medications you are taking to avoid potential interactions.
If you have a history of angioedema (swelling of the inner layer of the skin), use Pregabalin with caution, as it may increase the risk of angioedema. Your doctor may consider alternative medications based on your medical condition.
It's crucial to consult with your doctor about potential drug interactions, and this list may not cover all possible interactions. Your healthcare provider will provide personalized advice based on your specific health situation."
If you are allergic to pregabalin or any other ingredients of the Neugalin XR 165mg Capsule.
Pregabalin has a pregnancy category of C. As a result, it should only be taken if the potential benefits outweigh the dangers to the fetus.
Pregabalin, like other medicines, can pass into breast milk; thus, it should only be used in nursing mothers if the benefits clearly outweigh the risks
Talk to your doctor if:
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