Lino-M |.5mg+500mg | Type 2 Diabetes
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Lino-M (2.5mg+500mg) Tablet 10pcs

Generic: Linagliptin + metformin hydrochloride

Type: Tablet

Pack Size: 10 Pcs

Linagliptin and Metformin combination is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both Linagliptin and Metformin Hydrochloride is appropriate.

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Lino-M (2.5mg+500mg) Tablet is a combination of two medications, Linagliptin and Metformin, used to control high blood sugar levels in individuals with type 2 diabetes mellitus. This medication helps prevent serious diabetes-related complications, such as kidney damage, and blindness, and potentially reduces the risk of heart attack or stroke. Lino-M 500 can be prescribed alone or in combination with other diabetes medications.

  • The dose of Lino-M (2.5mg+500mg) Tablet will depend on individual medical conditions, blood sugar levels, and other medications being taken.
  • It is recommended to take Lino-M (2.5mg+500mg) Tablet with meals to reduce the risk of gastrointestinal side effects.
  • Take the medication at the same time each day for optimal benefits.
  • Do not discontinue use without consulting your doctor, as it helps in managing blood sugar levels and preventing complications.

Safety Advices


Avoid Alcohol. It can interfere with blood sugar control


Lino-M (2.5mg+500mg) Tablet is generally considered safe to use during pregnancy. Animal studies have indicated low or no adverse effects on the developing baby. However, there are limited human studies available. Use only if needed and prescribed by your doctor.


Lino-M (2.5mg+500mg) Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not pose any significant risk to the baby. Nonetheless, caution is advised, and it should be used only if needed.


Your ability to drive or operate machinery may be affected if your blood sugar levels are too low (hypoglycemia) or too high (hyperglycemia). Do not drive or operate machinery if you experience symptoms of low or high blood sugar.


Lino-M (2.5mg+500mg) Tablet should be used with caution. Dose adjustment may be necessary, so consult your doctor for appropriate dosing. Use of Lino-M (2.5mg+500mg) Tablet0 is not recommended. Regular monitoring of kidney function is advisable while taking this medication to avoid potential complications.


Lino-M (2.5mg+500mg) Tablet should be used with caution, and dose adjustments may be necessary. It is generally started at a low dose in these patients. Use of Lino-M (2.5mg+500mg) Tablet is not recommended. Patients with severe liver disease should not use this medication due to potential risks.

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Uses of Lino-M (2.5mg+500mg) Tablet
  • Type 2 Diabetes Mellitus
How does Lino-M (2.5mg+500mg) Tablet work?

Lino-M (2.5mg+500mg) Tablet is a combination of two antidiabetic medicines: Metformin and Linagliptin. 

  • Metformin is an antidiabetic medication (biguanide). It works by lowering the glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin.
  • Linagliptin is a DPP-4 inhibitor that works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and postmeal sugar levels. Together, they provide better control of blood sugar.
Side Effects of Lino-M (2.5mg+500mg) Tablet
  • Common: Nasopharyngitis, diarrhea, hypoglycemia (more common with sulfonylureas).
  • Serious: Lactic acidosis, pancreatitis.
Quick Suggestions:
  • Regular intake at the same time each day is important.
  • Inform your doctor about all nonprescription medicines.
  • Follow the diet and exercise program recommended by your doctor while taking this medication.
  • Lifestyle choices play a significant role in managing diabetes effectively alongside medication.
  • Drink extra fluids during exercise, activity increase, vomiting, or diarrhea.
Indication of Lino-M (2.5mg+500mg) Tablet

Lino-M 500 is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This

  • Linagliptin: Inhibits DPP-4 (dipeptidyl peptidase-4), preventing the degradation of incretin hormones (GLP-1 and GIP). This leads to increased insulin release and decreased glucagon secretion, improving glycemic control.
  • Metformin Hydrochloride: A biguanide that lowers basal and postprandial plasma glucose by decreasing hepatic glucose production, reducing intestinal absorption of glucose, and improving insulin sensitivity.
Dosage & Administration of Lino-M (2.5mg+500mg) Tablet

Immediate Release Tablets:

  • Maximum Dose: 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals.
  • Starting Dose:
    • For patients not currently treated with Metformin: 2.5 mg Linagliptin and 500 mg Metformin twice daily.
    • For patients currently treated with Metformin: 2.5 mg Linagliptin and the current Metformin dose twice daily.

Extended-Release Tablets:

  • Maximum Dose: 5 mg Linagliptin and 2000 mg Metformin Hydrochloride once daily with a meal.
  • Starting Dose:
    • For patients not currently treated with Metformin: 5 mg Linagliptin/1000 mg Metformin once daily.
    • For patients currently treated with Metformin: 5 mg Linagliptin and the current Metformin dose once daily.
    • For patients switching from immediate release: Match total daily doses.

Overdose Effects

  • Supportive Measures: Remove unabsorbed material, monitor clinically, and provide supportive treatment.
  • Hemodialysis: Unlikely to remove Linagliptin but effective for Metformin.
  • Cationic Drugs: Amiloride, digoxin, morphine, etc., may compete for renal tubular secretion, requiring monitoring and possible dose adjustments.
  • Carbonic Anhydrase Inhibitors: Drugs like topiramate may induce metabolic acidosis, increasing lactic acidosis risk.
  • Inducers of P-glycoprotein and CYP3A4 Enzymes: Rifampin can reduce Linagliptin exposure; alternative treatments are recommended.
  • Drugs Affecting Glycemic Control: Thiazides, corticosteroids, thyroid products, etc., may induce hyperglycemia; monitor closely.
  • Renal Impairment: Risk of Metformin accumulation and lactic acidosis.
  • Acute/Chronic Metabolic Acidosis: Including diabetic ketoacidosis.
  • Hypersensitivity: To Linagliptin or Metformin Hydrochloride.
Pregnancy & Lactation
  • Pregnancy: Use only if clearly needed due to lack of adequate studies.
  • Lactation: Exercise caution; effects are not well studied.
Precautions & Warnings
  • Lactic Acidosis: Discontinue immediately if suspected.
  • Pancreatitis: Discontinue if suspected.
  • Temporary Discontinuation: Necessary before radiologic studies with contrast materials or major surgery.
  • Vitamin B12 Monitoring: Annual hematologic parameter checks.
Storage Conditions:

Store in a cool, dry place (below 30°C), protected from light and moisture. Keep out of reach of children.

Frequently Asked Questions (FAQ)


The use of Metformin + Linagliptin does not usually cause hypoglycemia (low blood sugar) on its own. However, it can occur if you do not consume enough calories, miss or delay meals, drink alcohol, over-exercise, or take other antidiabetic medications along with it. Symptoms include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. Regular monitoring of blood sugar levels is important. Always carry glucose tablets, honey, or fruit juice with you.

Yes, long-term use of Metformin + Linagliptin can lead to vitamin B12 deficiency, as it interferes with its absorption in the stomach. Untreated deficiency may cause anemia and nerve problems, including tingling, numbness in hands and feet, weakness, urinary problems, changes in mental status, and difficulty maintaining balance. Consult your doctor if you experience these symptoms. Monitoring of B12 levels and supplementation may be advised by your doctor.
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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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