Glucomet 500 XR Tablet 1 Strip

✔️ Pregnancy & Lactation

Pregnancy: Diabetes management during pregnancy requires careful medical supervision. Insulin is often preferred to maintain blood glucose levels within the recommended range, although treatment decisions depend on the individual clinical situation. Consult your physician before starting or continuing metformin during pregnancy.

Breastfeeding: Metformin passes into breast milk in small amounts. Whether to use it during breastfeeding should be decided with a healthcare professional after considering the benefits and potential risks.

✔️ Dosage & Administration

The dosage of Glucomet XR should be individualized according to blood glucose levels, kidney function, tolerability, and the physician's instructions.

For adults taking extended-release metformin:

Initial dose: Commonly 500 mg once daily with the evening meal.

Dose adjustment: The dose may be increased gradually, often by 500 mg at weekly intervals, according to the patient's response and tolerability.

Maximum dose: The maximum recommended dose depends on the specific formulation and product labeling.

Administration instructions:

Take Glucomet XR with food, as directed by your physician.

Swallow the tablet whole. Do not crush, chew, or split it unless the product labeling specifically permits this.

Take it regularly at the same time each day.

Do not change the dose or stop treatment without medical advice.

Patients with kidney impairment: Kidney function must be assessed before treatment and monitored regularly. Metformin is contraindicated when the estimated glomerular filtration rate (eGFR) is below 30 mL/min/1.73 m². Treatment may need reassessment if eGFR falls below 45 mL/min/1.73 m².

✔️ Glucomet XR should not be used in patients with:

• Known hypersensitivity to metformin or any of the tablet ingredients.
• Severe renal impairment, with eGFR below 30 mL/min/1.73 m².
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• Acute conditions that may seriously impair kidney function, such as severe dehydration, shock, or serious infection.
• Conditions associated with significant tissue hypoxia, where metformin use is considered unsafe.
• Acute alcohol intoxication or alcoholism, according to the applicable product labeling.

✔️ Side Effects

Possible side effects of Glucomet XR include:

Common side effects

Nausea and vomiting

Diarrhea

Abdominal discomfort or pain

Loss of appetite

Taste disturbance

These gastrointestinal effects often improve as the body adjusts to treatment. Taking the medicine with food and gradually increasing the dose may improve tolerability.

Other possible side effects

Reduced vitamin B12 levels during long-term use

Skin rash, itching, or redness

Changes in liver function tests

Rarely, liver inflammation

Serious side effect — lactic acidosis: This is a rare but potentially life-threatening complication. Seek emergency medical care for symptoms such as unusual muscle pain, severe weakness, difficulty breathing, unusual sleepiness, abdominal discomfort, or feeling unusually cold, particularly during severe illness or dehydration.

✔️ Drug Interactions

Certain medicines may affect blood glucose control or increase the risk of adverse effects when taken with metformin.

• Corticosteroids: May increase blood glucose levels.
• Thiazide and other diuretics: May affect glucose control and kidney function.
• Thyroid hormone preparations: May alter blood glucose control.
• Estrogens and oral contraceptives: May increase blood glucose levels in some patients.
• Phenytoin and sympathomimetics: May reduce glucose-lowering effectiveness.
• Cationic medicines: Drugs such as amiloride, digoxin, morphine, procainamide, quinidine, trimethoprim, and vancomycin may interact with metformin through renal transport mechanisms.
• Nifedipine: May increase metformin absorption.
• Cimetidine: May affect metformin elimination and may require additional monitoring.

✔️ Storage:

• Store below 30°C.
• Protect from light and moisture.
• Keep out of reach of children.