Comet 850mg Tablet is an antidiabetic medicine that helps to control blood sugar in people with type 2 diabetes mellitus.
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Metformin is a medication belonging to the biguanide group, commonly prescribed to manage type 2 diabetes. It helps regulate elevated blood glucose levels in individuals with this condition. Type 2 diabetes is a chronic disorder characterized by impaired glucose processing in the body. People with type 2 diabetes either do not produce enough insulin or have insulin resistance, where the body's insulin does not function effectively. This form of diabetes is often associated with middle-aged or older individuals and is sometimes referred to as adult-onset diabetes.
Metformin is typically recommended when dietary changes and exercise alone are insufficient to control blood sugar levels in individuals with type 2 diabetes. It is considered the first-line therapy for managing this condition. Metformin works by enhancing the body's responsiveness to insulin, reducing the liver's production of glucose, and delaying the absorption of sugar in the stomach and intestines. Additionally, Metformin has off-label uses in treating women with polycystic ovary syndrome (PCOS), where it helps regulate menstrual cycles, balance hormones, lower blood sugar levels, and promote ovulation.
In general, Metformin has a low likelihood of causing significant side effects. Common side effects may include diarrhea, nausea, vomiting, or a metallic taste in the mouth. Lactic acidosis, a rare condition characterized by elevated lactic acid levels in the body, can occur in very rare cases and may present with symptoms like dizziness, drowsiness, and muscle pain. It's important to promptly seek medical attention if any of these symptoms arise.
To optimize the effectiveness of Metformin, it should be used in conjunction with a healthy lifestyle. This includes weight management, especially if one is overweight (BMI >25), a reduced-calorie diet (low in fat and sugar), and increased physical activity (at least 150 minutes of exercise per week). Discuss any medical conditions or concerns with your doctor to ensure safe and effective use of Metformin.
Avoid alcohol while taking Comet 850mg Tablet to prevent the risk of lactic acidosis, which can lead to unpleasant side effects.
Comet 850mg Tablet is generally not recommended during pregnancy. However, your doctor may prescribe it if they believe the benefits outweigh the risks. Do not take Comet 850mg Tablet during pregnancy without your doctor's advice.
Comet 850mg Tablet is not recommended if you are breastfeeding or planning to breastfeed your baby.
Comet 850mg Tablet, when used as monotherapy, does not cause hypoglycemia (low blood sugar) and therefore does not affect your ability to drive or operate machinery.
Use Comet 850mg Tablet cautiously, especially if you have a history of kidney diseases or conditions. Your doctor may adjust your dose based on your renal functions. METFORMIN is not recommended in cases of severe kidney disease. Regular monitoring of kidney function tests is important if you are taking Comet 850mg Tablet.
Take Comet 850mg Tablet with caution, especially if you have a history of liver diseases or conditions. Your doctor may need to adjust your dose accordingly.
Common side effects include gastrointestinal symptoms like nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. Rare side effects may involve hematological, metabolic, nervous system, gastrointestinal, hepatobiliary, and skin and subcutaneous tissue disorders. These side effects should be promptly reported.
Comet 850 (Metformin Hydrochloride tablet) is prescribed as an adjunct to diet and exercise to enhance glycemic control in both children and adults with type 2 diabetes mellitus.
Comet TM XR (Metformin Hydrochloride extended-release tablet) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Metformin, an antihyperglycemic agent, enhances glucose tolerance in type 2 diabetes patients. It reduces both basal and postprandial plasma glucose levels. Metformin achieves this by decreasing hepatic glucose production, reducing intestinal glucose absorption, and increasing peripheral glucose uptake and utilization. Importantly, it does not cause hypoglycemia and does not induce hyperinsulinemia, distinguishing it from sulfonylureas.
The dosages of Comet 850 and Comet TM XR should be tailored to individual effectiveness and tolerance, with careful consideration of maximum daily doses.
Comet 850mg Tablet should not be used in patients with:
Metformin falls under the Pregnancy Category B. Insulin is typically recommended during pregnancy to maintain near-normal blood glucose levels. Both Metformin immediate and extended-release tablets should only be used during pregnancy if deemed necessary by a healthcare provider.
Metformin is primarily excreted through the kidneys, and the risk of accumulation and lactic acidosis increases with renal function impairment. Patients with elevated serum creatinine levels for their age should not receive Metformin. In elderly patients, Metformin should be titrated carefully to establish the minimum effective dose due to age-related reduced renal function.
Store in a cool, dry place away from light and out of children's reach.
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