S-Fer Oral Solution 100ml

S-Fer Syrup- Sodium Ferred Sulfate Trihydrate

S-Fer Syrup is an oral iron preparation used to prevent and treat iron deficiency anemia in adults, children, and infants. It provides iron in a form that is generally less likely to cause gastrointestinal discomfort than some conventional iron preparations and does not typically cause tooth staining.

It may be used for:

• Iron deficiency anemia, particularly in children
• Iron supplementation during pregnancy when conventional oral iron preparations are poorly tolerated
• Anemia associated with conditions such as rheumatoid arthritis

S-Fer Syrup should be taken orally according to the dose prescribed by a healthcare professional.

Treatment of Iron Deficiency Anemia

• Neonates: Up to 2.5 mL twice daily. Lower doses may be used initially.
• Children 1–11 months: Up to 2.5 mL twice daily. A lower starting dose may be appropriate.
• Children 1–4 years: 2.5 mL three times daily.
• Children 5–11 years: 5 mL three times daily.
• Children 12–17 years: 5 mL three times daily, which may be gradually increased to 10 mL three times daily when clinically appropriate.

The appropriate dose for adults and individual patients should be determined according to the severity of iron deficiency and medical advice.

Prevention of Iron Deficiency

Neonates and infants 1–11 months: 1 mL once daily may be used for prophylactic supplementation in certain low-birth-weight, exclusively breastfed infants. Supplementation may begin around 4–6 weeks after birth and continue until mixed feeding is established, as advised by a healthcare professional.

Drug Interactions

Oral iron can interact with many medicines and may affect their absorption or effectiveness.

• Avoid using oral iron together with dimercaprol, as potentially harmful compounds may form.
• Iron can reduce the absorption of penicillamine, mycophenolate, fluoroquinolones, levodopa, carbidopa, thyroxine, and bisphosphonates.
• Iron may reduce the blood-pressure-lowering effect of methyldopa.
• Iron and tetracyclines can interfere with each other's absorption.
• Iron and zinc supplements may reduce each other's absorption.

Tell your doctor or pharmacist about all medicines and supplements you are taking. Some medicines may need to be taken at a different time from S-Fer.

Contraindications

S-Fer should not be used in patients with:

• Known allergy or hypersensitivity to sodium feredetate or any ingredient in the formulation
• Hemochromatosis or hemosiderosis
• Other conditions associated with excessive iron accumulation
• Repeated blood transfusions where iron overload may be present

Side Effects

S-Fer is generally well tolerated, but allergic reactions may occur rarely. Symptoms requiring immediate medical attention include:

• Itchy skin rash
• Swelling of the face, lips, tongue, or throat
• Difficulty breathing
• Difficulty swallowing

Iron preparations may also cause stools to become darker or black. This is generally harmless but can sometimes interfere with tests designed to detect hidden blood in stool.

Pregnancy and Breastfeeding

The use of medicines during the first trimester of pregnancy should be carefully considered, with the expected benefits weighed against potential risks. No specific harmful effects associated with sodium feredetate use during pregnancy or breastfeeding have been reported.

Pregnant or breastfeeding women should use S-Fer under medical supervision.

Precautions and Warnings

Use S-Fer cautiously in patients with:

• Hemolytic anemia
• Disorders affecting iron storage or absorption
• Existing gastrointestinal disease
• Conditions associated with abnormal iron metabolism

Long-term or excessive use, particularly in children, can result in iron accumulation and toxicity. The medicine should therefore be used at the recommended dose and duration.

Iron supplementation should generally be continued only when clinically indicated and according to medical advice.

Overdose

Taking excessive amounts of iron can cause serious poisoning, especially in children. Early symptoms may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Vomiting blood
• Rectal bleeding
• Severe tiredness or lethargy
• Circulatory collapse

Severe poisoning may also lead to high blood glucose and metabolic acidosis.

An iron overdose can be a medical emergency. Keep S-Fer safely out of children's reach and seek urgent medical attention if an overdose is suspected.

Therapeutic Class

Oral Iron Preparations

Storage

• Store below 25°C.
• Protect from direct light.
• Keep out of the reach of children.
• After opening, use the product within 3 months.
• Keep the container properly closed when not in use.