Nitrofurantoin is specifically indicated for the treatment & prophylaxis of urinary tract infections when due to susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
Dosage: Children: 5-7 mg/kg/day in four divided doses (contraindicated under 1 month of age). The average dose of Nitrofurantoin suspension for pediatric patients can be calculated as follows:-
For 7 to 11 kg Body Weight patient: ½ (2.5 ml) teaspoonfuls (4 times daily)
For 12 to 21 kg Body Weight patient: 1 (5 ml) teaspoonfuls (4 times daily)
For 22 to 30 kg Body Weight patient: 1 ½ (7.5 ml) teaspoonfuls (4 times daily)
For 31 to 41 kg Body Weight patient: 2 (10 ml) teaspoonfuls (4 times daily)
Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
Side effects: The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness, drowsiness