Joinix Plus Tablet

Uses of Joinix Plus Tablet

• Osteoarthritis

How does Joinix Plus Tablet work?

Joinix Plus Tablet, which contains Chondroitin sulfate and Glucosamine sulfate, is designed to effectively reduce joint problems, particularly in osteoarthritis. Chondroitin sulfate plays a crucial role in inhibiting certain substances that can damage cartilage and help maintain the structural strength of bones. It also possesses anti-inflammatory properties, which can reduce joint inflammation.

Glucosamine sulfate, on the other hand, stimulates the production of glycosaminoglycans, which are essential components for rebuilding cartilage. Additionally, it inhibits certain inflammatory substances, which helps in reducing joint inflammation.

By combining the effects of Chondroitin sulfate and Glucosamine sulfate, the Joinix Plus Tablet aims to provide relief from joint pain, improve joint function, and potentially slow down the progression of osteoarthritis. It is important to note that individual responses to the medication may vary, and it is recommended to follow the prescribed dosage and consult a healthcare professional for personalized advice.

Side Effects of Joinix Plus Tablet

• Gas
• Bleeding Disorder
• Cramps
• Bloating
• Diarrhea
• Headache
• Tiredness
• Indigestion
• Constipation
• Abdominal pain
• Wind (flatulence)

Quick Suggestions:

• Maintain a healthy body weight: Obesity can contribute to joint pain, so maintaining a healthy weight can help alleviate symptoms.
• Engage in low-impact exercises: Activities such as walking, biking, swimming, and light weightlifting can improve muscle strength and joint flexibility without putting excessive stress on the joints.
• Consider supplements: Glucosamine, chondroitin sulfate, vitamin D, and calcium supplements may support joint health. Turmeric and fish oil supplements can also help reduce inflammation.
• Include omega-3-rich fish in your diet: Fish like salmon, trout, tuna, and sardines are high in omega-3 fatty acids, which have anti-inflammatory properties and can benefit joint health.
• Practice good posture: Maintaining proper sitting posture and using support aids like rolled-up towels or footrests can help alleviate joint pain, particularly in the back.
• Apply heat or cold therapy: Alternating between hot and cold compresses can provide relief and reduce inflammation in the joints. Follow the recommended time and temperature guidelines.
• Be patient with treatment: It may take several weeks to see the benefits of joint pain treatments, including medications like Rejoint Tablet. Continue taking the prescribed medication as directed by your doctor.
• Monitor blood sugar levels: If you have diabetes, be mindful that Rejoint Tablet may affect blood sugar levels. Monitor your levels regularly and inform your doctor of any changes.
• Communicate with your doctor: If your symptoms do not improve after a few months of treatment or if you have any concerns, it's important to inform your doctor for further evaluation and adjustments to your treatment plan.
• Practice relaxation techniques: Engaging in activities that promote relaxation, such as meditation, reading, taking baths, or listening to calming music, can help manage stress and improve overall well-being.
• Avoid alcohol and quit smoking: Alcohol consumption can increase the risk of liver damage, which may be exacerbated when taking Rejoint Tablet. Quitting smoking is also beneficial for overall health and joint function.

Indication

As a dietary supplement, it is indicated for the treatment of osteoarthritis of the knee, hip, spine, hand, and other joints. It can also help with rheumatoid arthritis, sports injuries, migraines, psoriasis, vascular issues, kidney stones, and inflammatory bowel illness.

Pharmacology

Glucosamine and chondroitin sulfate play important roles in maintaining the health and integrity of cartilage and other connective tissues in the body. Here are some key points about their functions and benefits:

Glucosamine:

• Glucosamine is a naturally occurring amino sugar that is essential for the production of glycosaminoglycans (GAGs) such as hyaluronic acid, keratan sulfate, and chondroitin sulfate.
• GAGs bind to proteins to form proteoglycans, which are crucial components of articular cartilage, providing cushioning and shock absorption in the joints.
• When taken as a supplement, artificially generated glucosamine sulfate can increase the levels of glucosamine in the body, facilitating cartilage formation and repair.
• Glucosamine also stimulates the production of GAGs and proteoglycans by chondrocytes, the cells responsible for cartilage maintenance.

Chondroitin Sulfate:

• Chondroitin sulfate is a type of glycosaminoglycan present in connective tissues, particularly in articular cartilage.
• Similar to glucosamine sulfate, chondroitin sulfate acts as a substrate for proteoglycans and contributes to their synthesis.
• Chondroitin sulfate also helps protect healthy cartilage by inhibiting the activity of matrix metalloproteinase (MMP) enzymes, which break down proteoglycans.

Synergistic Effect of Glucosamine and Chondroitin Sulfate:

• When glucosamine and chondroitin sulfate are taken together, they have a synergistic effect in managing osteoarthritis.
• This combination has been found to be particularly effective in severe cases of osteoarthritis, providing relief from symptoms and slowing down the progression of the disease.
• In healthy individuals, glucosamine and chondroitin sulfate can help prevent the development of osteoarthritis.
• Studies have shown that this combination is as effective as nonsteroidal anti-inflammatory drugs (NSAIDs) in managing osteoarthritis pain, but with better tolerability and fewer side effects.
• Additionally, glucosamine and chondroitin sulfate may aid in the recovery of soft tissue injuries, such as tendon or ligament strains.

Dosage & Administration of Joinix Plus Tablet

Adult Dose for 250/200 mg tablet:

• The usual dosage is 1 to 2 tablets, three times daily.
• The dose may be adjusted based on the response to the medication and body weight.
• After 60 days, doses can be tapered as per individual requirements and cost convenience.
• The recommended dosage based on body weight is as follows:
  • Under 54 kg: 1000 mg glucosamine sulfate and 800 mg chondroitin sulfate per day.
  • 54 kg to 91 kg: 1500 mg glucosamine sulfate and 1200 mg chondroitin sulfate per day.
  • Over 91 kg: 2000 mg glucosamine sulfate and 1600 mg chondroitin sulfate per day.

Adult Dose for 750/600 mg tablet:

• The usual dosage is 1 tablet, two times daily, or as directed by the physician.
• Obese individuals may require higher doses based on body weight.
• The recommended dosage based on body weight is as follows:
  • Under 54 kg: 800 mg chondroitin sulfate and 1000 mg glucosamine sulfate per day.
  • 54 kg to 91 kg: 1200 mg chondroitin sulfate and 1500 mg glucosamine sulfate per day.
  • Over 91 kg: 1600 mg chondroitin sulfate and 2000 mg glucosamine sulfate per day.

Administration:

• The tablet should be taken orally.
• Swallow it as a whole with water; do not crush, break or chew it.
• It is recommended to take the tablet with food, preferably at meals.

It's important to follow the prescribed dosage and consult with a healthcare professional for personalized advice based on your specific condition and individual needs.

Interaction

Drug-Drug Interactions:

• Blood thinners (Warfarin): Joinix Plus Tablet may interact with blood-thinning medications like Warfarin. It is important to monitor the clotting parameters and consult with a healthcare professional for appropriate dosage adjustments.
• Cancer medications (Paclitaxel): Joinix Plus Tablet may interact with cancer medications such as Paclitaxel. Close monitoring and dosage adjustments may be necessary.
• Painkillers (Acetaminophen): Joinix Plus Tablet may interact with painkillers like Acetaminophen. It is advisable to consult with a healthcare professional to manage the concurrent use of these medications.
• Anti-diabetic medications (glimepiride, pioglitazone): Joinix Plus Tablet may interact with anti-diabetic medications such as glimepiride and pioglitazone. Regular monitoring of blood glucose levels and appropriate dosage adjustments may be required.

Drug-Food Interactions:

• Vitamin E, St. John's wort, and Ginkgo Biloba: It is recommended to avoid the intake of Vitamin E, St. John's wort (an antidepressant), and Ginkgo Biloba with Joinix Plus Tablet. These substances may potentially interact with the medication.

Drug-Disease Interactions:

• Impaired glucose tolerance, kidney or liver dysfunction: People with impaired glucose tolerance, kidney, or liver dysfunction should use Joinix Plus Tablet with caution. Close monitoring of blood glucose levels and renal/liver function may be necessary.
• Risk factor for cardiovascular disease: Individuals with a risk factor for cardiovascular disease should exercise caution when using Joinix Plus Tablet. Regular monitoring and appropriate management of cardiovascular health are important.
• Asthma: People with asthma should take Joinix Plus Tablet with caution and consult with a healthcare professional for guidance.

Contraindications

Glucosamine and Chondroitin have no known contraindications. However, documented hypersensitivity to Glucosamine and Chondroitin (e.g., allergies to shellfish or sulfur) is a contraindication.

Pregnancy & Lactation

The use of Glucosamine Sulfate or Chondroitin Sulfate supplements during pregnancy or breastfeeding is not recommended without proper medical guidance. There is limited research available on the effects of these substances on fetal development and their safety during pregnancy and breastfeeding. It is important to prioritize the health and well-being of both the mother and the baby during these periods. Therefore, if you are pregnant or planning to become pregnant, or if you are currently breastfeeding, it is advisable to consult with your healthcare provider before using Glucosamine Sulfate or Chondroitin Sulfate supplements. They can provide personalized advice based on your specific situation and guide you regarding the appropriate course of action.

Precautions & Warnings

• Avoid alcohol consumption during treatment with Joinix Plus Tablet, as it may increase the risk of liver damage.
• Patients with blood clots or leg circulation problems should not take Joinix Plus Tablet. It is important to consult a healthcare professional if you have these conditions.
• Use caution in pregnancy and breastfeeding. It is not recommended to self-administer Joinix Plus Tablet if you are pregnant or nursing. It is advisable to consult with a healthcare provider for appropriate guidance.
• Although Joinix Plus Tablet provides symptomatic relief for arthritis and may reduce inflammation, it is important to remain physically active within the limits of your condition. Adopting a healthy lifestyle and a diet rich in proteins are essential for managing arthritic conditions.
• If you have diabetes mellitus and are taking Glucosamine, it is recommended to regularly monitor your blood glucose levels.
• No special studies were conducted in patients with renal or hepatic impairment, but the toxicological and pharmacokinetic profiles of Glucosamine and Chondroitin do not show any restrictions. However, patients with severe hepatic or renal impairment should be under medical care.
• Glucosamine and Chondroitin should not be given to children. Their use in children has not been extensively studied, and it is important to consult a healthcare professional for appropriate treatment options for pediatric patients.

Storage Conditions

Store in a cool and dry place away from sunlight