Flexifen 10mg Tablet

Uses of Flexifen 10mg Tablet

• Muscle Spasm

How does Flexifen 10mg Tablet work?

Flexifen 10mg Tablet works by reducing or blocking the activity of certain nerves within a part of the brain that controls the contraction and relaxation of muscles, improving the movement of muscles and helping them relax.

Side Effects of Flexifen 10mg Tablet

• Dry mouth
• Sleepiness
• Weakness
• Dizziness
• Headache
• Nausea
• Muscle pain

Quick Suggestions:

• Regular exercise, such as jogging and walking, promotes muscle stretching, reducing the risk of spasms, tears, and sprains. Massages can also be beneficial.
• Maintain a comfortable temperature environment, avoiding extremes of cold and heat, and opt for loose-fitting clothing.
• Adequate rest and sleep are essential. Change your position every two hours to prevent pressure sores.
• Hot or cold therapy can be effective for treating muscle spasms. Apply an ice pack or hot pack to the affected muscle for 15-20 minutes.
• It's important to follow your doctor's advice and undergo regular blood tests to monitor liver function.
• If you have surgery requiring general anesthesia, inform your doctor that you are taking Flexifen 10mg Tablet.
• If you experience mood swings, depression, or have suicidal thoughts, seek immediate medical attention and consult your doctor.

Muscle Spasm:

Muscle spasms are characterized by sudden, involuntary contractions of muscles, often resulting in pain and discomfort. These spasms can occur when nerve impulses controlling muscle movements are disrupted. Common symptoms of muscle spasms include:

• Muscle tightness
• Joint stiffness
• Unusual posture
• Difficulty in moving
• Pain in affected muscles and joints

Muscle spasms can be triggered by various factors such as fatigue, stress, extreme temperatures (both hot and cold), infections, and wearing tight clothing.

The treatment of muscle spasms typically involves the use of muscle relaxants and exercise:

Muscle Relaxants: These medications work by sedating the muscles, helping to inhibit painful contractions.

Exercise: Regular exercise, including stretching exercises, can help prevent muscle spasms. Stretching exercises promote muscle flexibility, reducing the likelihood of spasms, tears, and sprains.

Pharmacology

Baclofen works by activating GABAB receptors in the spinal cord, which inhibits both monosynaptic and polysynaptic reflexes. This action blocks the release of neurotransmitters like glutamate and aspartate. Additionally, Baclofen can lead to central nervous system (CNS) depression by acting at intraspinal sites. It also has an antinociceptive (pain-relieving) effect.

Dosage & Administration of Flexifen 10mg Tablet

Adult Dose for Spasticity:

• Initially, start with 5 mg three times a day (tid) for 3 days.
• Increase to 10 mg tid for the next 3 days.
• Continue increasing in similar increments and intervals until either a total of 20 mg tid is reached or until the desired effect is achieved.
• The maximum daily dose should not exceed 80 mg.
• For elderly individuals, start with lower doses.

Child Dose for Spasticity:

• The recommended dose for children with spasticity is 0.75-2 mg/kg daily.
• You may initiate treatment with 2.5 mg four times daily and gradually increase the dose every 3 days until the desired effect is achieved.
• Maintenance doses are as follows:
  • For children aged 6-10 years: 30-60 mg daily
  • For children aged 2-6 years: 20-30 mg daily
  • For children aged 12 months to 2 years: 10-20 mg daily
• The maximum dose for children over 10 years of age is 2.5 mg/kg daily.

Renal Dose:

• Individuals with renal impairment may require a dose reduction. It's essential to consult with a healthcare professional to determine the appropriate dosage adjustment based on the degree of renal impairment.

Interaction

Drug-Drug Interactions: Flexifen 10mg Tablet can potentially interact with several medications, including:

• Painkillers such as hydrocodone, methadone, acetaminophen, ibuprofen, morphine, fentanyl, and tramadol.
• Opiate antagonists like naloxone.
• Other muscle relaxants, such as tizanidine.
• Medications used to treat mood disorders, including lithium and amitriptyline.
• Calcium channel blockers like diltiazem.
• Drugs used in the management of Parkinson's disease, such as levodopa and carbidopa.
• Antihistamines like promethazine.
• Sedative medications, including temazepam.
• Anti-convulsants like carbamazepine.

Drug-Food Interactions: It's advisable to avoid alcohol consumption while taking Flexifen 10mg Tablet, as it can intensify drowsiness, sleepiness, and difficulties in concentration.

Drug-Disease Interactions: Inform your doctor if you have specific medical conditions, including kidney dysfunction, seizures (fits), psychosis (a severe mental disorder characterized by impaired thoughts and emotions), or autonomic dysreflexia (a condition often associated with spinal cord injuries). These conditions may require special consideration when taking Flexifen 10mg Tablet, and your doctor can adjust your treatment accordingly.

Contraindications

• If you are allergic to baclofen or any other ingredients of the Flexifen 10mg Tablet.
• If you had a stomach ulcer.

Pregnancy & Lactation

Baclofen is classified as pregnancy category B3. While it can cross the placental barrier, its safe use during pregnancy has not been definitively established. The potential benefits should be weighed against the potential risks, and its use during pregnancy should be based on the physician's judgment. Baclofen is excreted in breast milk, but available evidence suggests that the amounts are small and unlikely to harm the infant.

Precautions & Warnings

Several precautions should be observed when using Baclofen, including careful dosage adjustment in patients with impaired renal function or undergoing chronic hemodialysis. Patients with psychiatric disorders, epilepsy, or a history of these conditions should be closely monitored as exacerbations may occur. Baclofen may lower the seizure threshold, potentially causing seizures upon discontinuation or in cases of overdose. Caution is advised in individuals with peptic ulcers, cerebrovascular diseases, or hepatic, renal, or respiratory failure. Respiratory and cardiovascular function should be closely monitored, especially in patients with cardiopulmonary or respiratory muscle weakness. Baclofen may lead to improved neurogenic bladder emptying, but acute urinary retention can occur in individuals with preexisting sphincter hypertonia.

Storage Conditions

• Flexifen 10mg Tablet should be stored at room temperature, protected from moisture and heat.
• Keep them out of the reach and sight of children and pets.
• Do not use expired medicines. Discard off the unused medicine appropriately. Do not flush the medicine into the sink.