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Zolaren Plus 1%+0.2% Ophthalmic Suspension
Brinzolamide (1%)
- Inhibits carbonic anhydrase in the ciliary processes, reducing aqueous humor secretion.
- Peak ocular hypotensive effect: 2-3 hours post-dosing.
Brimonidine Tartrate (0.2%)
- Dual action: reduces aqueous humor production and increases uveoscleral outflow.
- Peak ocular hypotensive effect: 2 hours post-dosing.
Key Benefit: Decreases elevated IOP, a major risk factor in glaucomatous optic nerve damage and visual field loss.
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✅ Description:
Benozol BR is a fixed combination of:
- Carbonic anhydrase inhibitor (Brinzolamide)
- Alpha-2 adrenergic receptor agonist (Brimonidine Tartrate)
Use:
Reduction of elevated intraocular pressure (IOP) in patients with:
- Open-angle glaucoma
- Ocular hypertension
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Use cautiously in patients on:
- High-dose salicylates.
- CNS depressants.
- Antihypertensives/cardiac glycosides.
- Tricyclic antidepressants.
- Monoamine oxidase inhibitors (MAOIs).
✔️ Dosage & Administration
- Dosage: One drop in the affected eye(s) three times daily.
- Instructions: Shake well before use.
- If using multiple ophthalmic drugs, administer at least 5 minutes apart.
- Pediatrics:
- Contraindicated in children under 2 years.
- Somnolence (50-83%) was observed in children aged 2-6 years.
- Geriatrics: No significant differences in safety or effectiveness compared to adults.
✔️ Side Effects
Common (3-30% of patients):
- Blurred vision
- Eye irritation/allergy
- Dry mouth
- Dysgeusia (bad taste)
- Ocular hyperemia
- Fatigue/drowsiness
- Headache
Other potential reactions:
- Ocular discomfort, discharge, keratitis, or pruritus.
- Systemic sulfonamide-related effects (rare but serious).
✔️ Contraindications
- Hypersensitivity to:
- Brinzolamide
- Brimonidine Tartrate
- Any ingredient in the formulation.
- Neonates and infants under 2 years of age.
✔️ Pregnancy & Lactation
- Pregnancy Category C:
Use only if the potential benefit justifies the risk to the fetus. - Lactation: Unknown if excreted in human milk. Evaluate risks vs. benefits.
✔️ Precautions & Warnings
- Systemic absorption: May lead to sulfonamide-associated severe reactions (e.g., Stevens-Johnson syndrome, agranulocytosis).
- Vascular insufficiency: Use cautiously in patients with:
- Depression
- Cerebral/coronary insufficiency
- Raynaud's phenomenon
- Orthostatic hypotension
- Thromboangiitis obliterans
- Contact lens users: Benzalkonium chloride (preservative) may be absorbed by soft lenses.
- Remove lenses before use and wait 15 minutes before reinsertion.
- Renal impairment: Not recommended due to Brinzolamide excretion via the kidney.
✔️ Storage Conditions
- Store at room temperature, protected from light.
- Avoid touching the dropper tip to surfaces.
- Do not use contents more than 1 month after opening.
- Shake well before use. Do not freeze.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
