Dexamethasone ophthalmic solution: Instill 1 drop into the conjunctival sac 3-5 times per day. Acute cases: up to 1 drop every hour if necessary.
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Sonexa 0.1% Eye Drops is indicated for the treatment of
Dexamethasone is a cortisone derivative whose high activity is due to the presence of a methyl group in the 16-alpha position and a fluorine atom in the 9-alpha position. The result is that its anti-inflammatory activity is 30 times greater and its overall therapeutic effectiveness is 8-10 times greater than that of hydrocortisone. Like other glucocorticoids, it is anti-allergic, anti-exudative, and anti-proliferative. Therapeutic concentrations of Dexamethasone are found in both the cornea and aqueous humor 15-30 minutes after local application of a single drop of 0.1% solution. These concentrations persist for 4-6 hours. The action of Dexamethasone is to inhibit phospholipase A2, the first step in prostaglandin synthesis. Also, Dexamethasone inhibits the chemotactic infiltration of neutrophils into the site of inflammation.
Injuries and ulcerating processes of the cornea, particularly those of bacterial or viral origin (herpes simplex, vaccinia), purulent infections of the conjunctiva and eyelids, tuberculosis, mycosis, glaucoma.
Corticosteroids may mask, activate, or aggravate an infection of the eye. If no improvement is seen after a few days of application, another form of treatment should be used. Do not touch the dropper tip to any surface, as this may contaminate the ophthalmic solution or ointment.
Store at room temperature & protect from light. It is desirable that the contents should not be used more than one month after first opening of the bottle.
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