Motigut Suspension 60ml

Uses of Motigut Suspension

• Treats Nausea and Vomiting

How does Motigut Suspension work?

Motigut Suspension is a medication with anti-emetic properties, meaning it can prevent or alleviate nausea and vomiting. It works by blocking the action of dopamine, a chemical messenger in the brain that transmits signals between nerve endings. This action inhibits muscle contraction in the digestive system and enhances the peristaltic movement in the food pipe, which aids in digestion and speeds up the process, resulting in a calming effect that relieves nausea or vomiting.

Side Effects of Motigut Suspension

• Extrapyramidal effects
• Drowsiness
• Galactorrhea,
• Gynecomastia
• Constipation or diarrhea
• Lethargy, loss of libido
• Skin rash, and itching
• Convulsions
• Arrhythmias and cardiac arrest,
• Dysrhythmias in people with cardiovascular disease or hypokalemia
• and people receiving chemotherapy for cancer are all potentially fatal. seizures and hypertensive crises in pheochromocytoma patients.

Quick Suggestions:

• Motigut Suspension helps relieve nausea, vomiting, and indigestion.
• It should be taken before meals as per the dose and duration prescribed by your doctor.
• It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
• Avoid consuming alcohol when taking Motigut as it may cause excessive drowsiness.
• Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake, and sugarless candy may help.
• Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
• Do not take it for longer than 7 days without consulting your doctor.

To ease nausea and vomiting, it is recommended to follow a healthy low-fat diet with small portions. 

1. Overly sweet food should be avoided while more salty food should be included, especially if vomiting has occurred.
2. Avoid eating your favorite food at the time when you usually experience vomiting to avoid losing interest in it.
3. Drinking cool beverages such as clear soups, flavored gelatin, and carbonated drinks can also help.
4. When drinking with a straw, sip slowly to prevent swallowing air that can lead to gas or acidity. It is best to wait at least 30 minutes after eating food before drinking water or any other liquid.
5. Lying down for at least two hours after eating can also help. If cooking food worsens your nausea or vomiting, it is recommended to let someone else cook or use prepared food from the freezer.
6. It is advised to avoid caffeine-containing beverages like coffee and tea, spicy or deep-fried processed foods, carbonated drinks, and acidic foods like citrus fruits or vegetables such as tomatoes.

Indication ofMotigut Suspension

A prescription medication called Motigut Suspension is used to treat nausea, vomiting, non-ulcer dyspepsia, heartburn with or without regurgitation of gastric contents into the mouth, and indigestion. It inhibits the brain chemical that causes nausea and vomiting while also enhancing food flow in the stomach to enhance digestion. Before meals, take Motigut Suspension at the dose and time recommended by the doctor.

Pharmacology

Domperidone works as a dopamine antagonist by blocking dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach. This action leads to an increase in the motility of the gastrointestinal tract. Domperidone mainly acts on the periphery and has minimal impact on the dopaminergic receptors in the brain, resulting in no psychotropic or neurological side effects. Domperidone improves the motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis, and regulates pyloric contraction. It also increases esophageal peristalsis and lower esophageal sphincter pressure, preventing the regurgitation of gastric contents.

Dosage & Administration of Motigut Suspension

• The adult oral dose of domperidone for nausea and vomiting is 10-20 mg every 4-8 hours, up to a maximum of 80 mg per day. For non-ulcer dyspepsia, the dose is 10 mg 3-4 times daily, with a maximum of 20 mg 3-4 times daily. The last dose should be taken at bedtime. For migraine, the dose is 20 mg every 4 hours, up to a maximum of 4 doses in 24 hours. The rectal dose for nausea and vomiting is 60 mg twice daily. There is no need for dosage adjustment in elderly patients or those with hepatic impairment.
• For children, the oral dose is 0.2-0.4 mg/kg every 4-8 hours daily. The rectal dose for children weighing over 15 kg but under 12 years old is 30 mg twice daily, and for those over 12 years old and over 35 kg, it is 60 mg twice daily.
• In patients with renal impairment, no dosage adjustment is needed for mild to moderate impairment. For severe impairment, dosing should be reduced to 1-2 times daily with prolonged treatment.

Take Motigut Suspension as advised by your physician. Shake well before use. Your doctor will decide the appropriate dose and duration of Motigut Suspension for you depending on your age, body weight, and disease condition.

Interaction

Motigut Suspension can interact with various medications used to treat heart problems, high blood pressure, depression, cancer, bacterial infections, gastrointestinal disorders, malaria, neuro-related conditions, and antifungal and anti-HIV drugs. It is also recommended to avoid consuming grapefruit juice, alcohol, and tobacco while taking Motigut Suspension as they can affect its efficacy. Patients with heart, kidney, liver disease, brain tumors, a history of gastrointestinal bleeding, or any bowel-related issues should exercise caution while using Motigut Suspension.

Contraindications

Domperidone should not be used in neonatal patients and those with documented hypersensitivity to the drug. Additionally, the use of Domperidone is contraindicated in cases where gastrointestinal stimulation could be harmful, such as in cases of gastrointestinal hemorrhage, mechanical obstruction, or perforation. People with prolactin-releasing pituitary tumors (prolactinoma) should also avoid the use of Domperidone as it can stimulate prolactin release and worsen the condition.

Pregnancy & Lactation

The safety of domperidone has not been established and therefore it is not recommended during pregnancy. Animal studies have not shown any teratogenic effects on the embryo. Domperidone may stimulate galactorrhea and improve post-natal lactation. It is excreted in breast milk, but in very small amounts that are not considered harmful.

Precautions & Warnings

• If you are allergic to any of the components present in Motigut Suspension, do not consume it. Prior to taking this medication, consult your doctor if you have liver or kidney problems, such as kidney function impairment or failure.
• Prolonged use of Motigut Suspension may increase the risk of heart rhythm disorders, such as arrhythmia and cardiac arrest, especially in elderly individuals (those over 60 years of age) or those taking doses higher than 30 mg daily.
• If you are using antifungal medications, have heart problems, or have AIDS/HIV, inform your doctor.
• If you experience heart rhythm disorders, such as palpitations, difficulty breathing, or loss of consciousness after taking Motigut Suspension, seek immediate medical attention.
• Domperidone is generally not recommended during pregnancy or breastfeeding, but it may be used in some cases to increase milk supply. If necessary, your doctor may prescribe it during breastfeeding.
• Before taking this medication, consult your doctor for advice. Adolescents (children aged 12-18 years) weighing less than 35 kg should not take Motigut Suspension.

Storage Conditions

Store at room temperature, in a dry place, away from direct heat and light. Also, keep all the medicines out of the reach and sight of children to avoid any accidental intake.