Vitilen Lotion 1% is a furocoumarin used to treat psoriasis and vitiligo.
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Vitilen Lotion 1% selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Vitilen Lotion 1%-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Vitilen Lotion 1% Lotion: is applied to a well-defined area of vitiligo by the physician, and the area is then exposed to a suitable credit of UVA. Initial exposure time should be conservative and not exceed that which is predicted to be one-half the minimal erythema dose. Treatment intervals should be regulated by the erythema response; generally once a week is recommended or less often depending on results. The hands and fingers of the person applying the medication should be protected by gloves or finger cots to avoid photosensitization and possible burns.
Pigmentation may begin after a few weeks, but significant repigmentation may require 6 to 9 months of treatment. Periodic re-treatment may be necessary to retain all of the new pigment. Idiopathic vitiligo is reversible but not equally reversible in every patient. Treatment must be individualized. Repigmentation will vary in completeness, time of onset, and duration. Repigmentation occurs more rapidly in fleshy areas such as the face, abdomen, and buttocks and less rapidly over less fleshy areas such as the dorsum of the hands or feet.
Methoxsalen lotion has been assigned to pregnancy category C by the FDA. Animal reproduction studies have not been conducted with topical methoxsalen, although it is a potent photocarcinogen in certain strains of mice. There are no controlled data in human pregnancy. It is also not known to what extent, if any, methoxsalen is absorbed systemically following topical administration. Methoxsalen lotion is only recommended for use during pregnancy when benefit outweighs risk.
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.
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